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Mammalian Genetics Unit

1995 establishments in EnglandGenetic engineering in the United KingdomGenetics or genomics research institutionsMammal geneticsMedical Research Council (United Kingdom)
Research institutes established in 1995Research institutes in OxfordshireVale of White Horse

The Mammalian Genetics Unit was a genetics and genomics research institute in Oxfordshire.

Excerpt from the Wikipedia article Mammalian Genetics Unit (License: CC BY-SA 3.0, Authors).

Mammalian Genetics Unit
Hungerford Road, Vale of White Horse

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N 51.58 ° E -1.32 °
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Hungerford Road

Hungerford Road
OX11 0GD Vale of White Horse
England, United Kingdom
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Harwell Synchrocyclotron

The Harwell Synchrocyclotron was a particle accelerator based at the Atomic Energy Research Establishment campus near Harwell, Oxfordshire. Construction of the accelerator began in 1946 and it was completed in 1949. The machine was of the synchrocyclotron design, with a 1.62T magnet of diameter 110" (2.8m) allowing protons to be accelerated to energies of 160-175MeV. Accelerator physicist John Adams, who later went on to lead design of CERN's SPS, was instrumental in the design and construction of this machine. Its main function was basic nuclear and particle physics research, with a focus on proton-proton and proton-neutron scattering.Comparisons were frequently drawn between the second cyclotron at the Harvard Cyclotron Laboratory and the Harwell Synchrocyclotron, and in 1974 clinicians from Oxford's Radcliffe Infirmary led by Dr T Hockaday floated plans to replicate the proton therapy work carried out at Massachusetts General Hospital with the accelerator. Initial preclinical research took place, including the measurement of proton beams in tissue equivalent plastics as part of the development of phantom materials by researchers at St Bartholomew's Hospital. Interest in this project continued into 1978, when the MRC met to make a funding decision. No clinical trials ever took place and decommissioning of the former AERE site began in the 1990s. Demolition of Hangar 7, which housed both the synchrocyclotron and the ZETA nuclear fusion project, was completed during financial year 2005/2006.

ZETA (fusion reactor)
ZETA (fusion reactor)

ZETA, short for Zero Energy Thermonuclear Assembly, was a major experiment in the early history of fusion power research. Based on the pinch plasma confinement technique, and built at the Atomic Energy Research Establishment in the United Kingdom, ZETA was larger and more powerful than any fusion machine in the world at that time. Its goal was to produce large numbers of fusion reactions, although it was not large enough to produce net energy. ZETA went into operation in August 1957 and by the end of the month it was giving off bursts of about a million neutrons per pulse. Measurements suggested the fuel was reaching between 1 and 5 million kelvins, a temperature that would produce nuclear fusion reactions, explaining the quantities of neutrons being seen. Early results were leaked to the press in September 1957, and the following January an extensive review was released. Front-page articles in newspapers around the world announced it as a breakthrough towards unlimited energy, a scientific advance for Britain greater than the recently launched Sputnik had been for the Soviet Union. US and Soviet experiments had also given off similar neutron bursts at temperatures that were not high enough for fusion. This led Lyman Spitzer to express his scepticism of the results, but his comments were dismissed by UK observers as jingoism. Further experiments on ZETA showed that the original temperature measurements were misleading; the bulk temperature was too low for fusion reactions to create the number of neutrons being seen. The claim that ZETA had produced fusion had to be publicly withdrawn, an embarrassing event that cast a chill over the entire fusion establishment. The neutrons were later explained as being the product of instabilities in the fuel. These instabilities appeared inherent to any similar design, and work on the basic pinch concept as a road to fusion power ended by 1961. In spite of ZETA's failure to achieve fusion, the device went on to have a long experimental lifetime and produced numerous important advances in the field. In one line of development, the use of lasers to more accurately measure the temperature was tested on ZETA, and was later used to confirm the results of the Soviet tokamak approach. In another, while examining ZETA test runs it was noticed that the plasma self-stabilised after the power was turned off. This has led to the modern reversed field pinch concept. More generally, studies of the instabilities in ZETA have led to several important theoretical advances that form the basis of modern plasma theory.