Hannibal Old Police Station and Jail

Green Double House is a historic duplex home located at Hannibal, Marion County, Missouri. It was built in 1857–1858, and was a one-story, "raised cottage" or the "double gallery" clapboard structure on a completely exposed squared rubble basement. The house was divided into two residences.: 56–57  It has been demolished. It was added to the National Register of Historic Places in 1986.

Robert Elliott's Wholesale Grocery is a historic commercial building located at Hannibal, Marion County, Missouri. It was built about 1886, and is a two-story brick structure. It features semicircular arches with fanlight tops on the first floor, upper windows with segmental arches, and an applied cornice, possibly metal.: 58–59  It was added to the National Register of Historic Places in 1986.

The United States Post Office at Hannibal, Missouri, is a federal building previously used as a post office and as a courthouse. It is also known as the Federal Building or the Naval Reserve Center, and is located at 600 Broadway. The building's architect was Mifflin E. Bell, and it was completed in 1888. The building is an excellent example of a late Second Empire architectural style. The United States District Court for the Eastern District of Missouri met in this building until 1960, and the U.S. Circuit Court for that district met here until that court was abolished in 1912. It is now owned by the city.: 4  It was listed on the National Register of Historic Places in 1980 as "Federal Building". It is located in the Central Park Historic District.

Broadway District is a national historic district located at Hannibal, Marion County, Missouri. The district encompasses 28 contributing buildings in the central business district of Hannibal. It developed between about 1866 and 1934, and includes representative examples of Italianate, Classical Revival, and Art Deco architecture. Notable buildings include the Lakenan Building (c. 1866), Kresge Building (1931), Second Farmers and Merchants Bank (c. 1910), Sproul-Cash Store (1901), Hannibal Trust Company (1909-1910), Hickman Block (c. 1865), and Robinson Brothers (c. 1894).: 18–27  It was listed on the National Register of Historic Places in 1986.

Benjamin Horr House, also known as the Standard Printing Company, is a historic home located at Hannibal, Marion County, Missouri. It was built about 1855, and is a two-story, vernacular Greek Revival style brick structure. It has a front gable roof with cornice. It is the earliest surviving building to have been used for education in Hannibal, having once housed a private school run by the family of one of Mark Twain's former schoolteachers.: 40–41  It was added to the National Register of Historic Places in 1986.

Hock Building, also known as Standard Printing Company, Warehouse No. 8, is a historic commercial building located at Hannibal in Marion County, Missouri. It was built in 1872, and is a three-story brick structure, three bays wide and eight deep. It features arched windows with thick cast-iron moldings above and iron pilasters at the first floor storefront.: 42–43  It was added to the National Register of Historic Places in 1986.

Standard Printing Company, also known as the Hayward Grocery Company, is a historic commercial building located at Hannibal, Marion County, Missouri. It was built in 1879, and is a three-story, nine bay by ten bay, Italianate style brick structure. It features segmental arched windows, a lavish bracketed and modillioned cornice, and a storefront with intact cornice and iron pilasters.: 38–39  It was added to the National Register of Historic Places in 1986.

Maple Avenue Historic District is a national historic district located at Hannibal, Marion County, Missouri. The district encompasses 148 contributing buildings in a predominantly residential section of Hannibal. It developed between about 1850 and 1950, and includes representative examples of Federal, Italianate, Late Victorian, Colonial Revival, and Bungalow / American Craftsman architecture. Located in the district are the separately listed Ebert-Dulany House, Rockcliffe Mansion, and Eighth and Center Streets Baptist Church. Other notable buildings include Central School by William B. Ittner, Pilgrim Congregational Church, McKnight House, Cliffside, Hogg House, the McVeigh House, the Mclntyre House, the Settles House, and the Clayton House. It was listed on the National Register of Historic Places in 2002.

Central Park Historic District is a national historic district located at Hannibal, Marion County, Missouri. The district encompasses 261 contributing buildings, 1 contributing site, and 4 contributing structures in a predominantly residential section of Hannibal. It developed between about 1840 and 1939, and includes representative examples of Romanesque Revival, Late Victorian, and Art Deco architecture. Located in the district are the separately listed Federal Building, Hannibal Old Police Station and Jail, and Eighth and Center Streets Baptist Church. Other notable contributing resources include Central Park with a war memorial monument and a life-size bronze statue of William Henry Hatch (1833-1894), City Hall (1909), old Missouri Guaranty Building (1894), Price Apartments (1904), YMCA (1910), Masonic Temple (1882), Park Methodist Church (1881, 1906), Retards Row (1855), Elks Building (1925), Holmes Building (c. 1904), Security Building (1912), Kerchival-Iakenan-Lathrop House, Admiral Coontz Birthplace, Inmaculate Conception Chapel (1854), Episcopalian Trinity Church (1860), and William C. Henn House (1937). It was listed on the National Register of Historic Places in 1982.

The buildings at 207–209 South Main St. are two historic commercial buildings located at Hannibal, Marion County, Missouri. They were built about 1860 and are two two-bay, two-story brick storefront buildings. They have high transom or fascia areas and segmental arched windows on the second story.: 52–53  It was added to the National Register of Historic Places in 1986.

Davidson Building was a historic commercial building located at Hannibal, Marion County, Missouri. It was built between 1903 and 1905, and was a two-story Romanesque Revival style building. It had a three-bay rock-faced ashlar facade and party walls. It featured arched windows with radiating voussoirs.: 44–45  It has been demolished. It was added to the National Register of Historic Places in 1986.

Mark Twain Hotel is a historic hotel building located at Hannibal, Marion County, Missouri. It was designed by Barnett, Haynes & Barnett and built in 1905. It is a four-story, Renaissance Revival style steel-frame structure with a granite foundation and beige pressed-brick exterior. The annex was built in 1918. It features semicircular arches over the main door and adjacent windows.: 50–51  It was then added to the National Register of Historic Places in 1986.