Sigma Alpha Epsilon Fraternity House (Columbia, Missouri)

Welch Hall is a historic residence located at 24 E Stewart Rd on Oak Hill in Columbia, Missouri. The residence is home to the University of Missouri chapter of Sigma Alpha Epsilon. The site was recognized by the Columbia Historic Preservation Commission as one of the city's Most Notable Historic Properties in 2004. It was nominated for the National Register of Historic Places in 2014.

The Columbia Cemetery in Columbia, Missouri has been in use as a cemetery since 1820. The cemetery historically contains, White, African-American, and Jewish (Beth Olem Cemetery, Beth Shalom Cemetery) sections. Located in the cemetery are a vernacular stone receiving vault (1887), and a Romanesque Revival style mausoleum (1911).Located on Broadway just west of Downtown Columbia, the cemetery contains many burials of prominent people associated with Missouri history, the University of Missouri, or the city of Columbia. It was listed on the National Register of Historic Places in 2007. It is still an operating cemetery with room for many more burials and celebrated its 200th anniversary in 2020.

Missouri Scholars Academy, or MSA, is a three-week residential summer program held on the University of Missouri campus in Columbia, Missouri for 330 of Missouri's gifted high school juniors. MSA exists to enrich and expand gifted education for individual students and gifted programs. MSA is a member of the National Conference of Governor's Schools. Missouri Scholars Academy should not be confused with the Missouri Student Association, with which it shares an acronym.

The Mizzou College of Health Sciences is the University of Missouri system’s only school of health professions and the state’s only public health program located on a health sciences campus. Its mission is to improve the health and well-being of others.The school is an important member of the University of Missouri Health System. Other members include the Sinclair School of Nursing, the School of Medicine, University Hospitals and Clinics and University Physicians.

The Missouri State Teachers Association Building is a historic building located at Columbia, Missouri. It was built in 1927 and houses the Missouri State Teachers Association Headquarters. The building is located on South 6th Street on the University of Missouri campus and is a two-story, Tudor Revival style brick building. It was the first building in the United States built specifically to house a state teachers association. A historical marker on the site commemorates the lands former tenant "Columbia College," the forerunner of the University of Missouri. It was added to the National Register of Historic Places in 1980.

Islamic Center of Central Missouri is a mosque located in Columbia, Missouri. Established in 1983, it is the first Islamic center in the state of Missouri.

The Sanford F. Conley House is a historic home located at Columbia, Missouri. It is an ornate 19th century residence in the Italianate architectural style. Built in 1868 as a residence for his family by the businessman Sanford Francis Conley (1838–1890). The house is near the University of Missouri campus. After being added to the National Register of Historic Places in 1973, the house was purchased by the university and houses the school's "excellence in teaching" program.

The Columbia station, also known as Missouri, Kansas, and Texas Railroad Depot or Katy Station, was built in 1909 by the Missouri–Kansas–Texas Railroad in downtown Columbia, Missouri. The station was one of two train stations serving Columbia in the 20th century, the other being the Wabash Railroad Station and Freight House constructed the same year. The building is the terminus of the MKT Trail, a rails-to-trails project that was built on the former spur of the railroad. Having housed a popular local restaurant named "Katy Station" after the building, it now houses a bar name "Shiloh's."The property was listed on the National Register of Historic Places in 1979.

The University of Missouri College of Engineering is one of the 19 academic schools and colleges of the University of Missouri, a public land-grant research university in Columbia, Missouri. The college, also known as Mizzou Engineering, has an enrollment of 3,204 students who are enrolled in 10 bachelor’s programs, nine master’s programs and seven doctorate programs. There are six academic departments within the College: Chemical and Biomedica Engineering; Civil and Environmental Engineering; Electrical Engineering and Computer Science; Industrial and Systems Engineering; Engineering and Information Technology; and Mechanical and Aerospace Engineering. The college traces its beginning to the first engineering courses taught west of the Mississippi River in 1849. The college was ranked 88th nationally by the U.S. News & World Report in 2016.

The Smithton Land Company was a group of American pioneers who in 1818 established the frontier village of Smithton, Missouri in the Boonslick region of Missouri, then the Missouri Territory. In 1821 the settlement was renamed Columbia, Missouri and relocated slightly East of its original location. Smithton was the first county seat of Boone County. The company and town were named after Thomas Adams Smith, the receiver of the land office in Franklin, Missouri.Smithton’s origin begins with the settlement of American pioneers from Kentucky and Virginia in an early 1800s region known as the Boonslick. Before 1815 settlement in the region was confined to small log forts because of the threat of Native American attack during the War of 1812. When the war ended settlers came on foot, horseback, and wagon, often moving entire households along the Boone's Lick Road and often bringing enslaved African Americans. By 1818 it was clear that the increased population would necessitate a new county be created from territorial Howard County. The Mouniteau Creek on the west and Cedar Creek on the east were obvious natural boundaries.Believing it was only a matter of time before a county seat was chosen, the Smithton Land Company was formed to purchase over 2,000 acres (8.1 km2) to established the village of Smithton near the present-day intersection of Walnut and Garth. In 1819 Smithton was a small cluster of log cabins in an ancient forest of oak and hickory; chief among them was the cabin of Richard Gentry, a trustee of the Smithton Company who would become first mayor of Columbia. In 1820 Boone County was formed and named after the recently deceased explorer Daniel Boone. The Missouri Legislature appointed John Gray, Jefferson Fulcher, Absalom Hicks, Lawrence Bass, and David Jackson as commissioners to select and establish a permanent county seat. Smithton never had more than twenty people, and it was quickly realized that well digging was difficult because of the bedrock. Springs were discovered across the Flat Branch Creek, so in the Spring of 1821 Columbia was laid off and the inhabitants of Smithton moved their cabins to the new town. The first house in Columbia was built by Thomas Duly in 1820 at what would become Fifth and Broadway. They renamed the settlement Columbia—a historical name for the United States. Columbia's permanence was ensured when it was chosen as county seat in 1821 and the Boone's Lick Road was rerouted down Broadway.

The State Historical Society of Missouri, a private membership and state funded organization, is a comprehensive research facility located in Columbia, Missouri, specializing in the preservation and study of Missouri's cultural heritage. Established in 1898 by the Missouri Press Association and made a trustee of the state in 1901, the Society is the official historical society of the state of Missouri and is located on the campus of the University of Missouri in Downtown Columbia, Missouri. The Society publishes the quarterly Missouri Historical Review, the only scholarly academic journal produced in the state. The Society engages in a number of outreach programs to bring Missouri's history to the public. Such programs are the Missouri History in Performance theatre, the Missouri History Speakers' Bureau, and the Missouri Conference on History. The collection of the Society, concerning pamphlets, books, and state publications, is over 460,000 items. In addition, the Society has over 500,000 manuscript items, 2,900 maps, over 150,000 state archival records, and over 57,000 reels of microfilm. In 2011, the Western Manuscript Collection, accessible in Columbia, Kansas City, Rolla, and St. Louis, Missouri, specializing in the preservation and collection of Missouri and Middle West history, was absorbed into the Society.

Second Baptist Church is a historic Baptist church located at 4th St. and Broadway in Columbia, Missouri. It was built in 1894, and has Gothic Revival and Romanesque Revival design elements. The church was founded by newly emancipated slaves many of whom were members of First Baptist Church. It was added to the National Register of Historic Places in 1980.