Pottlitzer House

Saint James Lutheran Church and School located in Lafayette, Indiana was founded in 1850 by German immigrants, is a member of the Lutheran Church–Missouri Synod and is a Confessional Lutheran congregation with approximately 800 active members. Average weekly worship attendance is approximately 550 at four services. The school associated with the church was also founded in 1850, and is the oldest school in Tippecanoe County. The school serves children from age 2 through grade 8. Current enrollment is approximately 225. Saint James Lutheran School is accredited by the state of Indiana, and National Lutheran School Accreditation.

The Marian Apartments, also known as Marian Flats, is a historic apartment building located at Lafayette, Tippecanoe County, Indiana. It was designed by Oliver W. Pierce, Jr. and built in 1907. It is a three-story, rectangular, brick building with limestone and wood trim. It features polygonal three-story projecting bays.They were listed on the National Register of Historic Places in 1983.

Upper Main Street Historic District is a national historic district located at Lafayette, Tippecanoe County, Indiana. Sixth Street was the City of Lafayette's eastern boundary when it was originally platted. By 1840, the boundary was extended to include Lake Erie and Wabash Railroad at Eleventh Street. This area became the cities commercial center. Businesses around Eleventh Street developed to meet the traveling publics needs. The Enterprise Hotel, at 1015 Main Street, as well as the Alt Heidelberg, American Lafayette and the Derby Hotel were early established by 1899.

Centennial Neighborhood District is a national historic district located at Lafayette, Tippecanoe County, Indiana, United States. The area originated as the Bartholomew and Davis Additions to Lafayette in 1829. Growth came rapidly after the Wabash and Erie Canal arrived in 1843, and continued with the arrival of the railroad in 1853. The Centennial Neighborhood Historic District takes its name from the Centennial School, which was constructed in 1876 on the centennial of the nation. The school was located on the northeast corner of Brown Street at North 6th Street. It has since been removed and a park was created at its original location.

The Thieme and Wagner Brewing Company is a brewery in Lafayette, Indiana.

St. John's Episcopal Church is a historic Episcopal church located at Lafayette, Tippecanoe County, Indiana. Founded by Parson Samuel R. Johnson, early services were held beginning in 1836–37 in the counting room of Thomas Benbridge. Benbridge had an accounting office. The first building dedicated on 30 Dec 1838 on Missouri St. A new Gothic Revival style church was built in 1858 on the Northwest corner of Sixth and Ferry. Major repairs were completed in 1887 with the addition of a Sunday School.It was listed on the National Register of Historic Places in 1978. It is located in the Centennial Neighborhood District.

Jefferson Historic District is a national historic district located at Lafayette, Tippecanoe County, Indiana. The district encompasses 161 contributing buildings, 2 contributing sites, and 22 contributing structures in a predominantly residential section of Lafayette. It developed between about 1853 and 1951 and includes representative examples of Italianate, Greek Revival, and Bungalow / American Craftsman style architecture. Notable contributing resources include the Deutsche Evangelische Kirche (1905), Isador Metzger House (c. 1866), Hubert Gilmartin House (c. 1868), B.F. Biggs Pump Factory Building (1872, 1885–1894), Deutsche Methodist Kirche (1885), Herman & Mary Fletemeyer House (c. 1897), Mohr House (c. 1865), Warrenberg-Reule Double House (c. 1878), Alfred Gaddis House (c. 1865), Wabash Valley House (1862), Haywood Tag Company Building (1928), and Jefferson High School (1927).It was listed on the National Register of Historic Places in 2001.

Trinity United Methodist Church, the first church in Lafayette, Indiana, was established in 1824, before the city was founded. The first meetings were held in the old log courthouse; the church was formally organized in 1827 with ten members. Trinity United Methodist is located at 314 North Sixth Street in Lafayette, Indiana 47901.

Enterprise Hotel, also known as Gasthaus Alt Heidelberg, is a historic hotel building located at Lafayette, Tippecanoe County, Indiana. It was built in 1895, and is a three-story, five-bay, rectangular, Italianate style brick building, with rear additions. It measures 42 feet wide and 32 feet deep. It is historically significant as a European style tavern / inn.: 2–3 It was listed on the National Register of Historic Places in 1984.

Mars Theatre is a historic theatre building at Lafayette, Tippecanoe County, Indiana. It was built in 1921, and is a four-story, rectangular, Georgian Revival style brick building, with limestone ornamentation and terra cotta panels. It measures 69 feet, 4 inches, wide and 141 feet, 4 inches deep. It was originally built as a vaudeville theater and sat 1,205 patrons.: 2–3  The building houses the Denis H. Long Center for the Performing Arts.It was listed on the National Register of Historic Places in 1981.

William Potter House, also known as the Potter House, is a historic home located at Lafayette, Tippecanoe County, Indiana. It was built in 1855, and is a two-story, Greek Revival style brick dwelling, with a front gable roof. A rear addition was added about 1880. The entrance features Doric order columns and opposing pilasters.: 2 It was listed on the National Register of Historic Places in 1983.

Temple Israel is a historic synagogue located at Lafayette, Tippecanoe County, Indiana. Its 1867 building is one of the oldest synagogue buildings in the United States.The congregation, which was formed in 1849, was the second Jewish congregation organized in Indiana. In 1874 it became a founding member of the Union of American Hebrew Congregations. The congregation moved to its third and present location on Cumberland Avenue in West Lafayette.