Ortaköy (literally Middle Village in Turkish) in Greek known as Agios Fokas (Άγιος Φωκάς) in the Byzantine period and Mesachorion (Μεσαχώριον, meaning "middle village") later, is a neighbourhood, formerly a small village, within the Beşiktaş district of Istanbul, Turkey, located in the middle of the European bank of the Bosphorus.
Ortaköy was a cosmopolitan area during the Ottoman era and the first decades of the Turkish Republic, with communities of Turks, Greeks, Armenians and Jews. Today the neighbourhood still hosts many different religious (Muslim, Jewish, Orthodox, and other Christian) structures. It is also a popular spot for locals and tourists alike, with its art galleries, night clubs, cafés, bars, and restaurants.
The Neo-Baroque style Ortaköy Mosque is a beautifully ornate structure, right on the jetty of Ortaköy, bordering the waters of the Bosphorus, and thus highly visible from the passing boats.
Several reputable schools, such as Kabataş Erkek Lisesi and Galatasaray University, are located in Ortaköy. The European pylon of the Bosphorus Bridge, one of the two bridges that connect the European and Asian banks of İstanbul, is also situated in this neighbourhood.
Ortaköy was the site of George W. Bush's speech during the NATO Summit of 2004, which he delivered at Galatasaray University.