Cantemir Palace in Istanbul

Ortaköy Mosque (Turkish: Ortaköy Camii) officially the Büyük Mecidiye Camii (Grand Imperial Mosque of Sultan Abdülmecid) in Beşiktaş, Istanbul, Turkey, is situated at the waterside of the Ortaköy pier square, one of the most popular locations on the Bosphorus. This structure is symbolic of the district of Ortaköy as it has a distinctive view of the Bosphorus Strait of Istanbul and the Bosphorus Bridge. The mosque can be viewed from the Bosphorus Cruise that is popular among tourists, to go from the Asian side of Istanbul to the European side on a ferry boat.

The Esma Sultan Mansion (Turkish: Esma Sultan Yalısı), a historical yalı located on the Bosphorus in the Ortaköy neighborhood of Istanbul, Turkey and named after its original owner Princess Esma Sultan, is used today as a cultural center after being redeveloped.

Archeion was a town of ancient Thrace on the Bosphorus, inhabited during Roman times.Its site is located near Ortaköy in European Turkey.

The Etz Ahayim Synagogue (Hebrew: קהל קדוש עץ החיים), also known as the Ortaköy Synagogue, is synagogue located in Ortaköy, Istanbul, Turkey, on the coast near the right leg of Bosphorus Bridge. It is unknown when the original synagogue was built, but it is estimated to be before 1703. The building also housed an academy for over one hundred years. The synagogue was totally destroyed by fire in 1941 with only the marble Aron Kodesh remaining intact. The synagogue was subsequently rebuilt. The synagogue serves Ashkenazi Jews and is also known as the 'Tree of Life' synagogue.

The Hatice Sultan Mansion (Turkish: Hatice Sultan Yalısı), a historical yalı (English: waterside mansion) located at Bosporus in Ortaköy neighborhood of Istanbul, Turkey and named after its original owner Hatice Sultan, is used today as a water sports club's building.The residence at Defterdarburnu (Defterdar Point) in Ortaköy was used as an orphanage and later as a primary school after the Ottoman dynasty was exiled following the foundation of the Turkish Republic.

Ortaköy (literally Middle Village in Turkish) in Greek known as Agios Fokas (Άγιος Φωκάς) in the Byzantine period and Mesachorion (Μεσαχώριον, meaning "middle village") later, is a neighbourhood, formerly a small village, within the Beşiktaş district of Istanbul, Turkey, located in the middle of the European bank of the Bosphorus. Ortaköy was a cosmopolitan area during the Ottoman era and the first decades of the Turkish Republic, with communities of Turks, Greeks, Armenians and Jews. Today the neighbourhood still hosts many different religious (Muslim, Jewish, Orthodox, and other Christian) structures. It is also a popular spot for locals and tourists alike, with its art galleries, night clubs, cafés, bars, and restaurants. The Neo-Baroque style Ortaköy Mosque is a beautifully ornate structure, right on the jetty of Ortaköy, bordering the waters of the Bosphorus, and thus highly visible from the passing boats. Several reputable schools, such as Kabataş Erkek Lisesi and Galatasaray University, are located in Ortaköy. The European pylon of the Bosphorus Bridge, one of the two bridges that connect the European and Asian banks of İstanbul, is also situated in this neighbourhood. Ortaköy was the site of George W. Bush's speech during the NATO Summit of 2004, which he delivered at Galatasaray University.

The F4, officially referred to as the F4 Boğaziçi Üni./Hisarüstü–Aşiyan funicular line (Turkish: F4 Boğaziçi Üni./Hisarüstü–Aşiyan füniküler hattı) is a 850 m (2,790 ft) long funicular railway, currently under construction, in Beşiktaş, Istanbul. When completed in June-2022, it will become the fourth funicular line in Istanbul as well as the longest, surpassing the F3 line by 100 m (330 ft). The F4 line will traverse a height difference of about 116.1 m (381 ft) and total travel time is estimated at 2 minutes and 30 seconds.The line will begin at Boğaziçi Üniversitesi station and head east to Aşiyan along the Bosporus. Connection to the M6 line at Boğaziçi Üniversitesi will be available. The entrance to Boğaziçi Üniversitesi station will be constructed next to the main entrance to Boğaziçi University.

Kabataş Erkek Lisesi or Kabataş High School (Ottoman Turkish: Kabataş Mekteb-i İdâdisi) is one of the oldest and most prominent high schools in Turkey. It is located in Ortaköy at Bosphorus in Istanbul.

The Istanbul nightclub shooting (also known as Reina massacre in Turkey) was a mass shooting incident on 1 January 2017 around 01:15 am local time, in which a terrorist shot and killed 39 people and wounded 79 others at the Reina nightclub in the Ortaköy neighbourhood of Istanbul, Turkey, where hundreds had been celebrating New Year's Day. Uzbekistan-born Abdulkadir Masharipov was arrested in Istanbul on 17 January 2017. Islamic State of Iraq and the Levant claimed credit for his actions. The first hearing in the trial of Masharipov and 51 accused accomplices was held on 11 December 2017, and the next hearing was held on 26 March 2018.

Galatasaray University (Turkish: Galatasaray Üniversitesi, French: Université Galatasaray) is a Turkish university established in İstanbul, Turkey in 1992, following an agreement signed in the presence of President François Mitterrand of France and President Turgut Özal of Turkey during a ceremony at Galatasaray High School, the mother school of the university. Turkey's Ambassador to France, Coşkun Kırca, played an important role in organizing the agreement. Galatasaray University is one of the most important members of the Galatasaray Community as Galatasaray High School and Galatasaray Sports Club, and is widely regarded as one of the most prestigious and notable universities in Turkey. The establishment has five faculties (Economic and Administrative Sciences, Law, Communications, Natural Sciences and Literature, Engineering and Technology); two institutes (Social Sciences, Applied Sciences), 200 teachers and 2500 students. As a participant in the European exchange programs Erasmus and Socrates, Galatasaray University accommodates around 50 European students. Meanwhile, 100 students of Galatasaray University travel each year to France within the framework of these exchange programs. In essence, Galatasaray University represents a secular tradition of teaching. Courses at Galatasaray University are tri-lingual: in Turkish, French and English. Apart from French which is the primary foreign language, fluency in English as the secondary foreign language is also required. Also, the students have to follow a third language course during their studies, which is either Spanish or German according to their choice. For the Faculty of Engineering, the preparatory period includes only one year of linguistic training. Galatasaray University is located at Ortaköy within the borough of Beşiktaş, a populous central district on the European side of İstanbul. The building that accommodates Galatasaray University was originally the Feriye Palace, a coastal summer palace on the Bosphorus built in 1871. Galatasaray University is heir to the centuries-old traditions of Galatasaray High School which was established in 1481 as the Galata Sarayı Enderun-u Hümayunu (Galata Palace Imperial School).

Parabolos was a town of ancient Thrace on the Bosphorus, inhabited during Roman times.Its site is located north of Defterdar Burnu in European Turkey.

The Feriye Palace (Turkish: Feriye Sarayı) is a complex of Ottoman imperial palace buildings along the European shoreline of the Bosphorus strait in Istanbul, Turkey. Currently, the buildings host educational institutions such as a high school and a university. The palace complex was commissioned by Sultan Abdülaziz (reigned 1861–76) in 1871, and designed by architect Sarkis Balyan. The buildings were built to meet the need of the extended family members of the imperial court for residence. The palace, which was constructed in addition to Dolmabahçe Palace and Çırağan Palace, took the name "Feriye" meaning "secondary" or "auxiliary" in Ottoman Turkish language. It consists of three main buildings on the waterfront, a ward for concubines, a small two-story building and outbuildings on the backside. On May 30, 1876, Sultan Abdülaziz was deposed by his ministers. He moved to Feriye Palace at his own request after a four-day stay in Topkapı Palace. Shortly after, he was found wrists cut at Feriye Palace. This was documented as a suicide at the time.Various members of the Ottoman imperial court resided in Feriye Palace until March 3, 1924, the abolition of the Ottoman Caliphate by the parliament of the newly founded Republic of Turkey. The buildings remained vacant for a period of time following the external deportation of the last caliph Abdülmecid II together with the court members.