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Mission Valley is a wide river valley trending east–west in San Diego, California, United States, through which the San Diego River flows to the Pacific Ocean. For planning purposes the city of San Diego divides it into two neighborhoods: Mission Valley East and Mission Valley West.Mission Valley was the site of the first Spanish settlement in California, established in 1769.Mission Valley currently serves as an important shopping and entertainment center for San Diego. Several condominiums and apartments can also be found in the area.

Mission Valley (formerly known as Mission Valley Center, Westfield Shoppingtown Mission Valley, and Westfield Mission Valley) is a retail complex consisting of a traditional open-air shopping mall owned by Real Capital Solutions, and a power center owned by Sunbelt Investment Holdings Inc., in Mission Valley, San Diego. The Mission Valley East was managed by the Dallas-based Centennial. Anchor stores include Macy's Home Furniture, Michaels, Target, Bed Bath & Beyond, and Nordstrom Rack. There is 1 vacant anchor store that was once Macy's. The power center across Mission Center Road known as Westfield Mission Valley West is anchored by big box retailers like DSW Shoes, West Elm, Old Navy, Trader Joe's and Marshalls.

The May Company Building (a.k.a. Macy's Mission Valley building) at 1702 Camino del Rio North, Westfield Mission Valley shopping center in San Diego is an example of original modernist architecture. The building originally housed the May Company California department store branch in the center, which would later become Robinsons-May in 1993, then Macy's in 2006 until it was closed in 2017. It is currently empty. The May Company Building at Mission Valley was designed in 1959 and opened in 1961. It was designed by William S. (Bill) Lewis, Jr. for LA-based AC Martin (later of Deems-Lewis), Frank L. Hope & Associates backstopped the project locally. It has been described by San Diego architectural photographer and historian Darren Bradley as an architectural icon, a "jewel box with a unique texture … striking architecture … the cladding all the way around the building … (is in) a modernist design that plays with light and shadow … designed to grab attention." This was part of a modernist landscape established in the area in the 1960s. As of January 2017, Westfield was considering a number of different plans for the use of the building.A 2015 study by the City of San Diego concluded that the building meets several criteria for qualification for the San Diego Resources register: an example of community development and of an identifiable architectural style (Modern Contemporary architecture of 1955–1965). However the report stated that the building did not qualify because of the lack of integrity of the original construction, due to replacement of some original tiles, altered walls, covering up of the building by new retail space set in front of it, removal of original pop-out display windows and "May Co." signage, and demolition of the 1958 canopy and columns, thus all together the alteration of more than 50% of the surface area of the original building exterior. It also did not qualify because it is not the "identifiable work" of a "listed Master Architect".

Mission Valley Center is a station on San Diego Trolley's Green Line and Special Event Service Line. The street-level station has side platforms. It is located near Camino De La Reina between Mission Center Road and Camino Del Este. The station is located next to the Westfield Mission Valley mall and serves a massive commercial corridor in the Mission Valley East neighborhood. Prior to July 2005, this station was served by the Blue Line until service between Old Town Transit Center and Mission San Diego was replaced by the Green Line upon its introduction in conjunction with the opening of the Mission Valley East extension.

University Heights is a neighborhood in Central San Diego, California centered on Park Boulevard and Adams Avenue. University Heights is bounded on the west and north by the edge of the mesa, the southern boundary is Lincoln Avenue, and the eastern boundary is Boundary Street along the western edge of Interstate 805. The area is filled with a number of restaurants, coffee shops, boutiques, and artist studios primarily on Park Boulevard and Adams Avenue. Live entertainment can be found most nights. Adjacent to Hillcrest, Normal Heights and North Park, additional restaurants, bars, coffee shops, and night clubs are within easy reach. The neighborhood sits in a central San Diego location with a broad spectrum of housing options, from cottages, apartments and condominiums, to million-dollar homes. Downtown, Balboa Park, San Diego Airport, Mission Valley, San Diego State University (SDSU, or "state"), are only a few minutes away.

Soichi is a Michelin Guide-starred Japanese restaurant in San Diego, California.

Hazard Center is a station on San Diego Trolley's Green Line. The street-level station has side platforms. It is located near the intersection of Hazard Center Drive at Frazee Road. The station is located across the street from the Hazard Center development and serves as a park and ride center, with spaces available in the lower portion of the adjacent garage. This stop is located in the densely populated Mission Valley West neighborhood. Prior to July 2005, this station was served by the Blue Line until service between Old Town Transit Center and Mission San Diego was replaced by the Green Line upon its introduction in conjunction with the opening of the Mission Valley East extension.

Marjorie Cook Education Center is a school based in San Diego, California. It is affiliated with the Institute for Effective Education.

United States University (USU) is a private for-profit university in San Diego, California. It offers graduate and undergraduate degrees in health sciences, business, and nursing as well as California Teaching Credentials. It is owned by the Aspen Group, Inc., a publicly held, for-profit post-secondary education company headquartered in New York.

Dharma Bum Temple is an American Buddhist temple in San Diego, California. The temple focuses on being an introductory center for beginners to learn Buddhism and aims to provide a space for Americans to practice Buddhism in the comfort of their own culture. It has its roots in Taiwanese Buddhism but identifies with ecumenical Buddhism, or interdenominational Buddhism. Dharma Bum Temple was founded on New Year's Eve in 2006 by a group of three people. It was originally located in Downtown San Diego, where it became popular among locals and college students from the nearby San Diego State University (SDSU). The temple was involved in the founding of the first Buddhist college fraternity in the United States, Delta Beta Tau. Dharma Bum Temple made headlines in local newspapers in 2017 with its campaign to buy the 1927-built Swedenborgian Church in University Heights, San Diego, which the temple relocated to later that year. Dharma Bum Temple holds free meditation and Buddhism classes for the general public and organizes community service events in the area. The temple is known for directing its members to other Buddhist temples in the area based on the forms of Buddhism that interest the person. The temple routinely hosts guest speakers from various traditions of Buddhism and organizes field trips to other Buddhist temples in the area.

Shirley Ann Place is a one-block-long street in the University Heights neighborhood of San Diego, California. The block, between Madison Ave. and Monroe Ave. and west of Texas Street, was designated the Shirley Ann Place Historic District by the City of San Diego for its 1920s Spanish Colonial Revival bungalows.The district also includes three properties similar in style and that were part of the original development: two additional bungalows on the south side of Monroe Avenue near a small local grocery store at the SE corner of Madison Ave. and Shirley Ann Pl.

Buddha For You is an antique Buddhist statuary store and gift shop in San Diego, California. The store offers a collection of existing and custom Buddhist statuary items and has been operating free meditation classes since 2009. The gift shop is best known for its role in the development of the first Buddhist college fraternity in the United States, Delta Beta Tau, at San Diego State University (SDSU).