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De Witt is a census-designated place (CDP) in the town of DeWitt, Onondaga County, New York, United States. It was first listed as a CDP prior to the 2020 census.The CDP is in eastern Onondaga County, in the southern part of the town of DeWitt. It is bordered to the northwest by the city of Syracuse, to the north by the village of East Syracuse, and to the east and south by Interstate 481, which separates it from the rest of the town of DeWitt. East Genesee Street is the main road through the CDP, leading west 4 miles (6 km) to downtown Syracuse and east 3 miles (5 km) to Fayetteville. New York State Route 92 follows East Genesee Street within the De Witt CDP, while State Route 5 follows it in the eastern part of the CDP, before turning north to take Erie Boulevard toward downtown. Le Moyne College is in the northwest corner of the CDP.

The Manlius Pebble Hill School (MPH) is a non-sectarian, coeducational, independent, pre-K through 12 school in DeWitt, New York. The school is the result of a merger in 1970 between The Manlius School, founded in 1869; and the Pebble Hill School, established in 1926. MPH marked its 150th anniversary in 2019. MPH is accredited by the New York State Association of Independent Schools, of which it is a founding member; and is a member also of the National Association of Independent Schools.

WSKO (1260 kHz) is a commercial AM radio station in Syracuse, New York. It has a sports radio format and is owned by Cumulus Media with studios on James Street. "The Score" is the flagship station for all Syracuse Mets baseball games. In addition to carrying CBS Sports Radio, a local program is heard in late mornings, The Manchild Show with Jim Lurch and Paul Esden. By day, WSKO is powered at 5,000 watts non-directional. At night, to protect other stations on 1260 AM from interference, it switches to a directional antenna with a four-tower array. The transmitter is on Andrews Road in DeWitt, near Interstate 481.

DeWitt is a town in Onondaga County, New York, United States. As of the 2020 census, the population was 26,074. The town is named after major Moses DeWitt, a judge and soldier. An eastern suburb of Syracuse, DeWitt also is the site of most of the campus and all of the academic buildings of Le Moyne College.

The Le Moyne Events Center is a multi-purpose arena in DeWitt, New York, that serves as the home arena for the Le Moyne Dolphins women's basketball and volleyball, and men's basketball teams on the campus of Le Moyne College. The venue is sometimes identified as the Event Center.The hardwood playing surface within the Events Center is named Ted Grant Court in honor of G. Edward Grant, a member of Le Moyne's inaugural class of 1951. Grant served as a trustee of Le Moyne College from 1981 to 1987, and was a financial supporter of the athletics program. Le Moyne's turf field is also named in his honor.

Le Moyne College is a private Jesuit college in DeWitt, New York. It was founded by the Society of Jesus in 1946 and named after Jesuit missionary Simon Le Moyne. At its founding, Le Moyne was the first co-educational Jesuit college in the United States.

East Syracuse is an incorporated village and a suburb of the City of Syracuse in eastern Onondaga County, New York, United States. As of the 2020 census, the population was 3,078. It is located immediately east of Syracuse, in the town of DeWitt.

Temple Beth El was a synagogue located at 3528 East Genesee Street, Syracuse, New York.

Christian Brothers Academy (CBA) is a private Catholic college preparatory school in suburban Syracuse, New York run by the Brothers of the Christian Schools, founded by St. John Baptist de La Salle. Located within the Roman Catholic Diocese of Syracuse, the school has more than 750 students in grades seven through twelve. It was founded in 1900 by the Christian Brothers, who still run the school, though most of the teachers are laity. In 1960, it moved from its original site on Willow Street in downtown Syracuse to its current location in suburban Dewitt on Randall Road. CBA was a boys-only school until September 1987. CBA opened to girls after Syracuse's all-girls school, The Franciscan Academy, closed and many of those parents actively lobbied to have CBA accept female students. In 2019, CBA was named a National Blue Ribbon School of Excellence, one of 50 private schools nationally, and the only private school in New York State. CBA was also ranked as the No. 1 Catholic high school in all of Upstate New York by NYup.com.Niche.com ranks CBA as the #1 best Catholic High School in the Syracuse area.In the past 25 years, the school has captured State Championships in baseball, boys basketball, football, girls lacrosse (4 state titles), boys lacrosse, boys soccer, ice hockey and cross country. In addition, individuals have won State Titles in track and swimming.

Dick Rockwell Field is a ballpark located on the campus of Le Moyne College in Syracuse, New York. It is home to the Le Moyne Dolphins baseball team of the NCAA Division I Northeast Conference, and previously had hosted both the Syracuse Salt Cats and Syracuse Spartans of the New York Collegiate Baseball League. It is named after former Le Moyne head baseball coach and athletic director Dick Rockwell.

Jamesville-DeWitt High School (JDHS) is a New York state public education facility located in the town of DeWitt, serving high school students (grades 9–12) in the Jamesville-Dewitt Central School District.

Meadowbrook is a Syracuse, New York neighborhood, located in the southeastern corner of the city. It corresponds to Onondaga County Census Tract 46. It is named after Meadow Brook, which runs through it and into Butternut Creek.