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Downtown Tijuana, officially Colonia Zona Centro, is an official neighborhood of Tijuana, Mexico. It is located within the Central Borough ("Delegación Centro") of the city, which is immediately southwest of the San Ysidro Port of Entry. It is bordered by Calle Artículo 123 and the Zona Norte neighborhood (and red light district) on the north, by Calle Ocampo and Zona Este and Zona Río on the east, and by the colonias (neighborhoods) Castillo, Lindavista, Altamira, Independencia, Morelos, and Juárez on the west and south. Avenida Revolución is the main tourist thoroughfare while Avenida Constitución is a main traditional shopping thoroughfare.

Zona Norte (officially Colonia Zona Norte, "North Zone (neighborhood)") is an official neighborhood, as well as a red light district located in Tijuana, Mexico. It is among the largest red light districts in North America known for its brothels, which present themselves in public as strip clubs and bars, similar to gentlemen's clubs in the United States. Many bars and strip clubs in Tijuana's red light district in which women are the feature entertainment also operate as brothels, which offer attached hotel rooms for short intervals of time. Many other bars, styled "lady bars", function as less explicit social clubs where prostitutes and nude sex shows are not accommodated on site, but fichas (drinks for the working ladies) are offered at elevated prices, and freelance prostitutes look for clients. These compare in most respects to the hostess bars in Japan. The red light district in Tijuana is also known for street prostitution, particularly behind the main strip clubs on Calle Coahuila, in a large high-traffic alley named "Primer Callejón Coahuila". Illicit drug sales are also common to the red light district, which happens night and day in plain view because the local police tolerates it in the form of collecting their commission. The dealer's selling phrase is "¿Cuantos?" meaning "How much?" in Spanish. Heroin use and theft, not common elsewhere in Mexico, are rampant here. Due to its proximity to San Diego, California, it is frequented by US citizens, as well as locals. The district is also known as La Coahuila for the name of the primary avenue that runs through it.

The Roman Catholic Archdiocese of Tijuana (Latin: Archidioecesis Tigiuanaënsis) is a Metropolitan Archdiocese in Mexico. It is based in the city of Tijuana, Baja California, and the province has the suffragan dioceses of Ensenada, La Paz en la Baja California Sur, and Mexicali.

Dorian's was a department store chain based in Tijuana, Baja California, Mexico. Dorian's was established in Downtown Tijuana in 1959.On November 9, 1977, a fire ripped through the block where Dorian's was located, however after only 17 working days the store was back open, with half the square footage housed in tent-like structures built in a nearby parking lot.Carlos Slim's Grupo Carso bought Dorian's Tijuana, S.A. de C.V. in 2004 and operated it as a subsidiary of Inmuebles Borgru, S.A. de C.V. which in turn was a subsidiary of Inmuebles Carso, S.A.B. de C.V. In that same year, Dorian's expanded to Cancun, Chihuahua, Leon, Merida, and Monterrey after purchasing five JCPenney stores, which operated in Mexico since 1995. A store opened in the new Las Misiones mall in Ciudad Juárez in 2004 and closed shortly thereafter (now Liverpool). In 2009, Dorian's had 14 stores in Tijuana: Downtown Tijuana (Corner of 2nd and Niños Héroes) Plaza Río Tijuana Plaza Carrousel Centro Comercial Mesa de Otay, Otay Centenario Cancun - Plaza Las Américas (formerly JCPenney) Chihuahua, Chihuahua - Plaza de Sol (formerly JCPenney) Ensenada - downtown La Paz, Baja California Sur - Downtown Forjadores León, Guanajuato - Plaza Mayor (formerly JCPenney) Mérida - Plaza las Américas (formerly JCPenney) Mexicali - Centro Comercial Cachanilla Monterrey area - San Pedro Garza García (formerly JCPenney) San Luis Río Colorado, SonoraStarting in April 2009, the 14 Dorian’s department stores were integrated into Sears México and operated under the name Sears. However, the Downtown Tijuana store was closed in May 2009 and is now the Plaza de la Tecnología, a market hall of retail technology vendors.

San Ysidro (Spanish for "St. Isidore", Spanish pronunciation: [san iˈsiðɾo]) is a district of the City of San Diego, immediately north of the Mexico–United States border. It neighbors Otay Mesa West to the north, Otay Mesa to the east, and Nestor and the Tijuana River Valley to the west; together these communities form South San Diego, a practical exclave of the City of San Diego. Major thoroughfares include Beyer Boulevard and San Ysidro Boulevard.

Centro is a borough of the municipality of Tijuana in Baja California, Mexico. It is the main historical and economic borough of Tijuana. Delegación Centro includes the old downtown, or Zona Centro, the new business district (Zona Río), Zona Norte (the red-light district), Agua Caliente, and other adjacent neighborhoods ("zonas"). This is the historical midpoint of Tijuana; City Hall is located here as well as most of the tourist areas such as Avenida Revolución, and the business districts. The Tijuana Cultural Center (CECUT for CEntro CUltural de Tijuana) and Plaza Río, until recently the largest mall in the state, are both located here in the Zona Río.

Tijuana Municipality is a municipality in the Mexican state of Baja California. Its municipal seat is located in the city of Tijuana. According to the 2020 census, the municipality had a population of 1,922,523. Montserrat Caballero of the MORENA is the current mayor. The municipality comprises the largest part of the Tijuana metropolitan area. Tijuana is bordered to the south by the municipalities of Rosarito Beach and Ensenada; to the east, by the municipality of Tecate; to the west, by the Pacific Ocean; and to the north, by the international border with the United States, specifically the County of San Diego, California. The area of the municipality of Tijuana is 879.2 km² (339.46 sq mi); the municipality includes part of the Coronado Islands, located off the coast of the municipality in the Pacific Ocean. The city of Tijuana lies just south of San Diego, California. The adjacent city and former borough of Tijuana is Rosarito Beach.

Plaza Viva Tijuana is an open-air shopping center in the Empleados Federales neighborhood of Tijuana, located immediately across Frontera Street from what was, until 2012, the entrance to Mexico for all pedestrians crossing from the U.S. side of the San Ysidro of the border. It houses numerous pharmacies targeted at U.S. customers, handicraft and souvenir shops, restaurants, and one of Tijuana's largest gay nightclubs (formerly "Éxtasis" now "Club Fusion").In 2012, the Puerta México pedestrian crossing on the west side of the southbound vehicular crossing, controversially, closed, replaced by the new Puerta México Este pedestrian entry to Mexico on the east side. It still allowed pedestrians to walk westward 500m and exit to Tijuana in front of Plaza Viva Tijuana, but also gave pedestrians easy access to areas on the east side of the border such as the Zona Río. Business plummeted for merchants in the center, by up to 80% in one instance.In July 2016, pedestrian traffic once again increased to the area around Plaza Viva Tijuana as it became the starting point of the new pedestrian walkway to and from the new PedWest pedestrian crossing, via which pedestrians cross to Virginia Avenue and the Las Americas Premium Outlets on the U.S. side. Since then, there has been a reconfiguration and the pedestrian terminus is immediately west of the Plaza, across Aves. Alberto Aldrete and José María Larroque.

San Ysidro Transit Center is a San Diego Trolley station in the San Ysidro neighborhood of San Diego, California. The station is the southern terminus of the Blue Line and is located on a short rail spur of the San Diego and Arizona Eastern Railway. Located just north of the San Ysidro Port of Entry at the Mexico–United States border, San Ysidro serves primarily as a way to provide access to downtown for the thousands of international commuters and tourists who travel between San Diego County and Tijuana, Mexico. It also provides access to the large shopping areas, including the Las Americas Premium Outlets which are connected to the stop via a pedestrian walkway. An intercity bus station is located adjacent to the station. It is the second busiest station in the San Diego Trolley, with nearly 18,000 passengers using the station each day.

The San Ysidro Port of Entry (aka San Ysidro Land Port of Entry or San Ysidro LPOE) is the largest land border crossing between San Diego and Tijuana, and the fourth-busiest land border crossing in the world (second-busiest excluding the crossings between Mainland China and its two Special Administrative Regions) with 70,000 northbound vehicles and 20,000 northbound pedestrians crossing each day, in addition to southbound traffic. It connects Mexican Federal Highway 1 on the Mexican side with Interstate 5 on the American side. The San Ysidro Port of Entry is one of three ports of entry in the San Diego–Tijuana metropolitan region.

San Diego–Tijuana is an international transborder agglomeration, straddling the border of the adjacent North American coastal cities of San Diego, California, United States, and Tijuana, Baja California, Mexico. The 2020 population of the region was 5,456,577, making it the largest bi-national conurbation shared between the United States and Mexico, and the second-largest shared between the US and another country. The conurbation consists of the San Diego metropolitan area (defined as all of San Diego County), (2020 population 3,298,634) in the United States and the municipalities of Tijuana (2020 pop. 1,922,523), Rosarito Beach (126,980), and Tecate (108,440) in Mexico. It is the third most populous region in the California–Baja California region, smaller only than the metropolitan areas of Greater Los Angeles and the San Francisco Bay Area. The largest centers of the urban area maintain global city status and as a whole the metropolitan region is host to 13 consulates from Asian, European, North American, Oceanian, and South American nations. Over fifty million people cross the border each year between Tijuana and San Diego, giving the region the busiest land-border crossing in the world. Since the implementation of the North American Free Trade Agreement (NAFTA) in 1994, San Diego–Tijuana has become a dominant commercial center in the United States and Mexico. The economic success of globalization has allowed San Diego–Tijuana to grow to the third richest region in the former Californias region, with a GDP of $136.3 billion in 2002. Renowned for natural beauty, tourism is a leading industry in the region and its coastal environs have been paramount factors in the growth of action sports-lifestyle companies. Other key industries include military, biotech, and manufacturing. San Diego–Tijuana traces its European roots to 1542 when the land was explored by Portuguese explorers on behalf of imperial Spain. In 1601 it was mandated by the Spanish viceroy in Mexico City that safe ports be found, one of which would be San Diego Bay, for returning Spanish trade ships from Manila to Acapulco. During this mission, explorer Sebastián Vizcaíno was also told to map the California coast in great detail, leading to the further exploration of the modern-day site of San Diego–Tijuana. Since 2010, statewide droughts in California and in northern Mexico have further strained the San Diego–Tijuana binational region's water security.

Caesar's is a restaurant on Avenida Revolución in Tijuana, Mexico, famous as the home of the Caesar salad. Restaurateur Caesar Cardini, an Italian immigrant, opened the restaurant in 1923, and it is now under chef Javier Plascencia, leading chef of Baja Med cuisine.