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The Metallurgical Laboratory (or Met Lab) was a scientific laboratory at the University of Chicago that was established in February 1942 to study and use the newly discovered chemical element plutonium. It researched plutonium's chemistry and metallurgy, designed the world's first nuclear reactors to produce it, and developed chemical processes to separate it from other elements. In August 1942 the lab's chemical section was the first to chemically separate a weighable sample of plutonium, and on 2 December 1942, the Met Lab produced the first controlled nuclear chain reaction, in the reactor Chicago Pile-1, which was constructed under the stands of the university's old football stadium, Stagg Field. The Metallurgical Laboratory was established as part of the Metallurgical Project, also known as the "Pile" or "X-10" Project, headed by Chicago professor Arthur H. Compton, a Nobel Prize laureate. In turn, this was part of the Manhattan Project – the Allied effort to develop the atomic bomb during World War II. The Metallurgical Laboratory was successively led by Richard L. Doan, Samuel K. Allison, Joyce C. Stearns and Farrington Daniels. Scientists who worked there included Enrico Fermi, James Franck, Eugene Wigner and Glenn Seaborg. At its peak on 1 July 1944, it had 2,008 staff. Chicago Pile-1 was soon moved by the lab to Site A, a more remote location in the Argonne Forest preserves, where the original materials were used to build an improved Chicago Pile-2 to be employed in new research into the products of nuclear fission. Another reactor, Chicago Pile-3, was built at the Argonne site in early 1944. This was the world's first reactor to use heavy water as a neutron moderator. It went critical in May 1944, and was first operated at full power in July 1944. The Metallurgical Laboratory also designed the X-10 Graphite Reactor at the Clinton Engineer Works in Oak Ridge, Tennessee, and the B Reactor at the Hanford Engineer Works in the state of Washington. As well as the work on reactor development, the Metallurgical Laboratory studied the chemistry and metallurgy of plutonium, and worked with DuPont to develop the bismuth phosphate process used to separate plutonium from uranium. When it became certain that nuclear reactors would involve radioactive materials on a gigantic scale, there was considerable concern about the health and safety aspects, and the study of the biological effects of radiation assumed greater importance. It was discovered that plutonium, like radium, was a bone seeker, making it especially hazardous. The Metallurgical Laboratory became the first of the national laboratories, the Argonne National Laboratory, on 1 July 1946. The work of the Met Lab also led to the creation of the Enrico Fermi Institute and the James Franck Institute at the university.

Disciples Divinity House of the University of Chicago is a Christian seminary associated with the Christian Church (Disciples of Christ) and the University of Chicago Divinity School.

The Quadrangle Club is a membership club at the University of Chicago. It is located at 1155 East 57th Street (the southeast corner of 57th Street and University Avenue) in Chicago. It has a full-service dining room, a bar, several lounges, and sleeping quarters for members and/or their guests. It has 17 sleeping rooms, including 5 suites with an extra sitting room. It is one of the few locations in the city of Chicago that has green clay tennis courts.

Seminary Cooperative Bookstores, Inc., founded in 1961, is a not-for-profit bookstore with two branches in Chicago. Its flagship, known colloquially as the Seminary Co-op or simply the Sem Co-op, is located at 5751 S. Woodlawn Avenue. Prior to October 2012, it was located a block away in the basement of the Chicago Theological Seminary, next to the campus of the University of Chicago, and stocked the largest selection of academic volumes in the United States throughout an extensive maze of shelves.The Co-op also operates 57th Street Books, also in the Hyde Park neighborhood, which houses a carefully curated collection of general interest titles, including kids' books, science fiction, mysteries and cookbooks. The Co-op's reputation was so great that Columbia University invited manager Jack Cella to either open a branch in New York City or leave and open a new store there. Until the university gained its own neighborhood academic bookstore in the late 1990s, many Columbia scholars ordered books from the Co-op. Currently, the Co-op has over 53,000 members, 3,500 of whom are located overseas. The following countries have at least 100 members: Japan, the United Kingdom, Germany, Canada, and Australia. The following countries have at least 50 members: Taiwan, Spain, the Netherlands, Italy, Israel, Hong Kong, France, Brazil, and Korea. Other nations with significant membership include Sweden, Switzerland, Norway, Ireland, India, and Argentina. In September 2008, the Co-op launched The Front Table, a web magazine for book lovers and Co-op members. Barack Obama's patronage of the bookstore garnered attention in the wake of his election.In 2017 the Co-op announced that on April 1, 2017 it would take back the shares of "inactive members" who had not purchased anything in 2 years, unless they contacted the store and requested otherwise. In addition, the Co-op no longer requires the purchase of stock to become a member and receive 10% of monthly purchases in store credit.In 2019, the Seminary Co-op Bookstores, Inc. became the country’s first not-for-profit bookstores whose mission is bookselling. As the stores' director Jeff Deutsch writes in his letter about the change, "Establishing the store as a not-for-profit (as opposed to its current status as a strict retail operation) also acknowledges the financial realities of our business model, which privileges cultural value over financial dividends. Our new structure codifies this mission, allowing us to invest in the browsing experience rather than overly concern ourselves with the vagaries of the market at a given moment."

The Franke Institute for the Humanities is located in Regenstein Library at the University of Chicago. It promotes sharp, rigorous scholarship in the humanities and social sciences by sponsoring research fellows, organizing talks, workshops, and conferences, and attracting participants from the university, the city of Chicago, and a global community of artists, academics, and other interested audiences. The institute is named for Barbara E. and Richard J. Franke, who have supported it financially since its founding in 1990. The current director is Professor James Chandler. The Franke Institute for the Humanities is a member of the Consortium of Humanities Centers and Institutes (CHCI).

The Gary Becker Milton Friedman Institute for Research in Economics is a collaborative, cross-disciplinary center for research in economics. The institute was established at the University of Chicago in June 2011. It brought together the activities of two formerly independent economic research centers at the university: the Milton Friedman Institute for Research in Economics and the Becker Center on Chicago Price Theory, founded by Richard O. Ryan.The institute is named for two globally influential economists: Gary S. Becker (1930–2014) and his mentor, Milton Friedman (1912-2006), both winners of the Nobel Memorial Prize in Economic Sciences. While they pursued different scholarly paths, Becker and Friedman shared a fundamental belief that economics, grounded in empirical research, is a powerful tool to understand human behavior. While Friedman is known for his lasting contributions to macroeconomics and monetary economics, Becker is recognized for extending microeconomic analysis to a wide range of fields and topics such as marriage, the family, criminal behavior, and racial discrimination.A collaboration of the University of Chicago Booth School of Business, Law School, Department of Economics, and the Harris School of Public Policy, the institute builds bridges across disciplines and subfields of economics. Its research conferences, workshops, and initiatives bring economists and scholars from related fields together to share perspectives and refine ideas. The institute also sponsors an active visiting scholars program and offers programs and support for students and promising young researchers. The institute supports research initiatives in traditional Chicago strengths such as price theory, law and economics, and human capital, as well as topical inquiries into important policy issues such as fiscal imbalance, systemic risk, policy uncertainty, and economics of the family, and newer areas like field experiments in economics. The institute is directed by Michael Greenstone. An Institute Research Council of distinguished faculty from collaborating university units advises the institute.

The Chicago Theological Seminary (CTS) is a Christian ecumenical American seminary located in Chicago, Illinois, and is one of several seminaries historically affiliated with the United Church of Christ. It is the oldest institution of higher education in Chicago, originally established in 1855 under the direction of the abolitionist Stephen Peet and the Congregational Church (now the United Church of Christ) by charter of the Illinois legislature.In addition to being a seminary of the United Church of Christ, CTS offers students coursework necessary to be ordained by the Metropolitan Community Church denomination. It was the first theological school to introduce the field education experience into a seminary curriculum, the first to create a distinct Department of Christian Sociology in an American theological school, and the first seminary to award a degree in divinity to a woman in the United States (Florence Fensham, 1902).

The Joseph Regenstein Library, often referred to by students as "The Reg", is the main library of the University of Chicago, named after the industrialist and philanthropist Joseph Regenstein. It is one of the largest repositories of books in the world and is noted for its brutalist architecture.

The University of Chicago Graduate Library School (GLS) was established in 1928 to develop a program for the graduate education of librarians with a focus on research. Housed for a time in the Joseph Regenstein Library, the GLS closed in 1989 when the University decided to promote information studies instead of professional education.. GLS faculty were among the most prominent researchers in librarianship in the twentieth century. Alumni of the school have made a great impact on the profession including Hugh Atkinson, Susan Grey Akers, Bernard Berelson, Michèle Cloonan, El Sayed Mahmoud El Sheniti, Eliza Atkins Gleason, Frances E. Henne, Virginia Lacy Jones, William Katz Judith Krug, Lowell Martin, Miriam Matthews, Kathleen de la Peña McCook, Elizabeth Homer Morton, Benjamin E. Powell, W. Boyd Rayward, Charlemae Hill Rollins, Katherine Schipper, Ralph R. Shaw, Spencer Shaw, Peggy Sullivan, Maurice Tauber and Tsuen-hsuin Tsien. In February 2016, Carla Hayden (PhD, 1987) was nominated by President Obama to serve as Librarian of Congress. She was confirmed in July 2016.

The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois, United States. The university has its main campus in Chicago's Hyde Park neighborhood.The university is composed of an undergraduate college and four graduate research divisions, which contain all of the university's graduate programs and interdisciplinary committees. It has eight professional schools: the Law School; the Booth School of Business; the Pritzker School of Medicine; the Crown Family School of Social Work, Policy, and Practice; the Harris School of Public Policy; the Divinity School; the Graham School of Continuing Liberal and Professional Studies; and the Pritzker School of Molecular Engineering. The university has additional campuses and centers in London, Paris, Beijing, Delhi, and Hong Kong, as well as in downtown Chicago.University of Chicago scholars have played a major role in the development of many academic disciplines, including economics, law, literary criticism, mathematics, physics, religion, sociology, and political science, establishing the Chicago schools in various fields. Chicago's Metallurgical Laboratory produced the world's first human-made, self-sustaining nuclear reaction in Chicago Pile-1 beneath the viewing stands of the university's Stagg Field. Advances in chemistry led to the "radiocarbon revolution" in the carbon-14 dating of ancient life and objects. The university research efforts include administration of Fermi National Accelerator Laboratory and Argonne National Laboratory, as well as the Marine Biological Laboratory. The university is also home to the University of Chicago Press, the largest university press in the United States.The university's students, faculty, and staff include 99 Nobel laureates. The university's faculty members and alumni also include 10 Fields Medalists, 4 Turing Award winners, 52 MacArthur Fellows, 26 Marshall Scholars, 53 Rhodes Scholars, 27 Pulitzer Prize winners, 20 National Humanities Medalists, 29 living billionaire graduates, and 8 Olympic medalists.

The University of Chicago Extension Division Library School was one of the pioneering training programs for librarians in the United States. The library school was a section within the Extension Division's Class-Study Department. It closed in 1903 after receiving controversial criticisms from the American Library Association.

University of Chicago Library is the library system of the University of Chicago, located on the university's campus in Chicago, Illinois, United States. It is the ninth largest academic library in North America, with over 11.9 million volumes as of 2019. The library also holds 65,330 linear feet of archives and manuscripts and 245 terabytes of born-digital archives, digitized collections, and research data.The library has borrowing privileges with several other archives, museums, and libraries in the Chicago area, including the Art Institute of Chicago Library, the Chicago History Museum, Fermilab, the Field Museum of Natural History, and the Newberry Library.The library was founded by president of the University of Chicago, William Rainey Harper, who set the course for Special Collections as a “working collection” in 1891. The library's collections are located in six sites: the Joseph Regenstein Library, the John Crerar Library, the D'Angelo Law Library, the Joe and Rika Mansueto Library, the Eckhart Library for mathematics and computer science, and the School of Social Service Administration Library.