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The Villa of Maxentius is an imperial villa in Rome, built by the Roman emperor Maxentius. The complex is located between the second and third miles of the ancient Appian Way, and consists of three main buildings: the palace, the circus of Maxentius and the dynastic mausoleum, designed in an inseparable architectural unit to honor Maxentius.

The Circus of Maxentius (known until the 19th century as the Circus of Caracalla) is an ancient structure in Rome, Italy, part of a complex of buildings erected by emperor Maxentius on the Via Appia between AD 306 and 312. It is situated between the second and third miles of the Via Appia, between the basilica and catacombs of San Sebastiano and the imposing late republican tomb of Caecilia Metella, which dominates the hill that rises immediately to the east of the complex. It is part of the Appian Way Regional Park.

The church of Sant'Urbano alla Caffarella is found on the edge of the Caffarella Park in the southeast of Rome. It was originally a Roman temple. In the 10th century, the structure was modified and consecrated as a church and it was extensively altered in the 17th century.

The Vigna Randanini are Jewish Catacombs between the second and third miles of the Appian Way close to the Christian catacombs of Saint Sebastian, with which they were originally confused. The catacombs date between the 2nd and 5th-centuries CE, and take their name from the owners of the land when they were first formally discovered and from the fact that the land was used as a vineyard (vigna). While Vigna Randanini are just one of the two Jewish catacombs in Rome open to the public, they can only be visited by appointment. They are situated below a restaurant and a private villa and entrance is from the Via Appia Pignatelli side. These catacombs were discovered by accident in 1859, although there is evidence that they had been pillaged before then. They cover an area of 18,000 square metres and the tunnels are around 700 metres long, of which around 400 can be seen.

The Tomb of Caecilia Metella (Italian: Mausoleo di Cecilia Metella) is a mausoleum located just outside Rome at the three mile marker of the Via Appia. It was built during the 1st century BC to honor Caecilia Metella, who was the daughter of Quintus Caecilius Metellus Creticus, a consul in 69 BC, and the wife of Marcus Licinius Crassus who served under Julius Caesar and was the son of the famous triumvir with the same name, Marcus Licinius Crassus. The mausoleum was probably built in 30–10 BCE by her son who also had the same name, Marcus Licinius Crassus.The Tomb of Caecilia is one of the most well known and well preserved monuments along the Via Appia and a popular tourist site. In 2013, the museum circuit of the Baths of Caracalla, Villa of the Quintilii, and the Tomb of Caecilia Metella was the twenty-second most visited site in Italy, with 245,613 visitors and a total gross income of €883,344.

The Catacombs of San Sebastiano are a hypogeum cemetery in Rome (Italy), rising along Via Appia Antica, in the Ardeatino Quarter. They are one of the very few Christian burial places that have always been accessible. The first of the former four floors is now almost completely destroyed.

San Sebastiano fuori le mura (Saint Sebastian beyond the Walls), or San Sebastiano ad Catacumbas (Saint Sebastian at the Catacombs), is a minor basilica in Rome, Central Italy. Up to the Great Jubilee of 2000, San Sebastiano was one of the Seven Pilgrim Churches of Rome, and many pilgrims still favour the traditional list (not least perhaps because of the Catacombs and because the Santuario della Madonna del Divino Amore, which replaced it in the list, is farther from the inner city).

The Mausoleum of Maxentius was part of a large complex on the Appian Way in Rome that included a palace and a chariot racing circus, constructed by the Emperor Maxentius. The large circular tomb was built by Maxentius in the early 4th century, probably with himself in mind and as a family tomb, but when his young son Valerius Romulus died he was buried there. After extensive renovation the mausoleum was reopened to the public in 2014.

Capo di Bove is an archaeological site on the Appian Way on the outskirts of Rome, Italy. It contains the thermal baths of a vast property owned in the 2nd century AD by Herodes Atticus and his wife Annia Regilla.

The Caffarella Park (Italian: Parco della Caffarella) is a large park in Rome, Italy, protected from development. It is part of the Parco Regionale Appia Antica (Appian Way Regional Park). The park is contained in the Caffarella Valley and is bordered on its northern side by the Via Latina and on its southern by the Appian Way. It stretches from the main Rome-Pisa railroad tracks near the Aurelian Wall at its western edge to the Via dell'Almone to the east. It contains several sites of archaeological interest, as well as a working farm, and has considerable ecological value, with 78 species of birds and fauna. The Catacombs of Rome and Colli Albani (Rome Metro) are nearby.

The Catacomb(s) of Callixtus (also known as the Cemetery of Callixtus) is one of the Catacombs of Rome on the Appian Way, most notable for containing the Crypt of the Popes (Italian: Cappella dei Papi), which once contained the tombs of several popes from the 2nd to 4th centuries.

The Ardeatine massacre, or Fosse Ardeatine massacre (Italian: Eccidio delle Fosse Ardeatine), was a mass killing of 335 civilians and political prisoners carried out in Rome on 24 March 1944 by German occupation troops during the Second World War as a reprisal for the Via Rasella attack in central Rome against the SS Police Regiment Bozen the previous day. Subsequently, the Ardeatine Caves site (Fosse Ardeatine) was declared a Memorial Cemetery and National Monument open daily to visitors. Every year, on the anniversary of the slaughter and in the presence of the senior officials of the Italian Republic, a solemn state commemoration is held at the monument in honour of the fallen. Each year, 335 names are called out, a simple roll call of the dead, to reinforce that 335 discrete individuals symbolise a collective entity.