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South Park is a small urban park and eponymous neighborhood in the larger South of Market neighborhood of San Francisco, California, consisting of 0.85 acres (0.34 ha) of public ground. The neighborhood centers on the small, oval-shaped park and South Park Street, which encircles the park. South Park is bounded by Second, Third, Bryant, and Brannan streets.The two halves of the South Park Street re-join at both ends of the park and continue for short, straight stretches before terminating at Second Street on one end and Third Street on the other. This creates a curved line of buildings, which gives the street and park an unusual enclosed, urban character. Local businesses, restaurants and many apartment buildings dot the street. In January 2016, the park was closed temporarily in order to undergo a $2.8 million renovation, which will include comprehensive infrastructural and cosmetic upgrades.

715 Harrison is a nightclub venue located in the SoMa neighborhood of San Francisco, California, known mostly for hosting Club X since 1989 and previously City Nights from 1985 to 2020. The club is designated by San Francisco as a legacy business and is additionally known within the Bay Area for being one of the few venues consistently open to guests above 18 years of age, rather than 21, as is the case with most clubs.

The Schmidt Lithography Co. Clock Tower, built in San Francisco in 1921, was once headquarters to the Max Schmidt Lithography Company, once the largest printing company on the West Coast. The Clock Tower's building occupies two blocks at Second and Bryant Streets and was rumored to have once housed handball and volleyball courts, roof gardens, and a hospital for the Lithography Company.The Clock Tower was built adjoining an older building on the property; the Lithography plant covered an area of 181 by 252 feet on Second Street. The Clock Tower stands at 170 feet tall.The future of the tower was jeopardized by the building of the Bay Bridge Viaduct in the 1930s, but ultimately prevailed to stand in its original location of 461 Second Street, where it is located today. Because of the preservation and the tower's identifiable characteristics, it has become a landmark as the official "timepiece of Rincon hill".

The Hotel Utah, is a historic mixed-use building known as a saloon bar, live music venue, and residential hotel, built in 1908 and located in the South of Market neighborhood of San Francisco, California. It is known for its diverse open mic nights, which have historically attracted some people who have later become famous. It is also known as The Utah Inn, The Hotel Utah Saloon, and simply The Utah. The Hotel Utah has been listed as a San Francisco Designated Landmark since November 2, 2018.

4th and Brannan station is an at-grade Muni Metro light rail station located in the median of 4th Street at Brannan Street in the South of Market (SoMa) district of San Francisco, California. It opened on November 19, 2022, as part of the Central Subway project. The station is served by the T Third Street line which runs between Chinatown and Sunnydale.

The Trocadero Transfer was an after hours dance club in San Francisco from its opening in December 1977 to the late 1990s. It was located at 520 4th Street at Bryant in the SoMa neighborhood. In 2000, the club was bought by a new owner, remodeled, and renamed to the Glas Kat. In late 2011, the club was again remodeled, and the name was changed to The Grand.

The Central Subway is an extension of the Muni Metro light rail system under construction in San Francisco, California, from the Caltrain commuter rail depot at 4th and King streets to Chinatown, with stops in South of Market (SoMa) and Union Square. The subway is the second phase of the San Francisco Municipal Transportation Agency's Third Street Light Rail Project. The first phase opened to the public as the T Third line in 2007. Ground was broken for the Central Subway on February 9, 2010. Tunnel boring for the Central Subway was completed at Columbus and Powell Street in the North Beach neighborhood of San Francisco on June 11, 2014. Originally set to open in late 2018, the Central Subway is (as of December 2021) projected to open to the public in October 2022. With the addition of the Central Subway, the T Third line is projected to become Muni Metro system's highest ridership line by 2030.The extension will serve major employment and population centers in San Francisco that are underserved by rapid transit. SoMa is home to the headquarters of many of San Francisco’s major software and technology companies, and substantial residential growth is projected there. Union Square, located in the city's downtown, is a primary commercial and economic district. Chinatown is the most densely populated neighborhood in the city. The Central Subway will connect these areas to communities in eastern San Francisco, including Mission Bay, Dogpatch, Bayview–Hunters Point and Visitacion Valley. The project was initiated after the Embarcadero Freeway was torn down following the 1989 Loma Prieta earthquake, when activist Rose Pak "almost single-handedly persuaded the city to build" the Central Subway to compensate Chinatown for the loss of the fast cross-town connection.The budget to complete the Central Subway is $1.578 billion. The project is funded primarily through the Federal Transit Administration’s New Starts program. In October 2012, the FTA approved a Full Funding Grant Agreement, the federal commitment of funding through New Starts, for the Central Subway for a total amount of $942.2 million. The Central Subway is also funded by the State of California, the Metropolitan Transportation Commission, the San Francisco County Transportation Authority and the City and County of San Francisco.

Saison is a San Francisco restaurant that earned the highest rating of three stars from the Michelin Guide in 2014. It is located in the SoMa district. The founders and owners are executive chef Joshua Skenes and wine director Mark Bright.

Room 641A is a telecommunication interception facility operated by AT&T for the U.S. National Security Agency, as part of its warrantless surveillance program as authorized by the Patriot Act. The facility commenced operations in 2003 and its purpose was publicly revealed in 2006.

The Tool Box was a leather bar for gay men in San Francisco that operated from 1962 to 1971 on the east corner of 4th Street and Harrison Street. It was the first leather bar in the South of Market, and a meeting spot where influential personalities of the early San Francisco leather scene gathered. After a prominent feature in Life magazine in 1964, it was considered the archetypal leather bar, helping to cement San Francisco's reputation as the “gay capital” of the US. The bar's history was short-lived: from 1965 onwards, the epicenter of the leather scene shifted towards Folsom Street (most notably Febe's bar), which ultimately led to its closing in 1971. The Tool Box is commemorated at the San Francisco South of Market Leather History Alley. The patronage of the Tool Box included influential personalities of the early San Francisco leather scene, among others artist Bill Tellman, Jack H. (owner of the Detour and the Slot, co-owner of Febe's), artist Mike Caffee (creator of the logo and a statue for Febe's), as well as the Satyrs Motorcycle Club (oldest gay motorcycle club in the US) from Los Angeles. The artist Chuck Arnett also worked as a bartender at the Tool Box. On June 26th 1964, Life magazine published a cover story titled "Homosexuality in America", which not only brought San Francisco as a hub of gay life into public consciousness, but also the Tool Box. The article opened with a two-page photo-spread of its interior with patrons dressed in leather beneath a mural, photographed by Bill Eppridge. In the 1991 anthology, Leatherfolk, Jack Fritscher described the article as "an image-liberating historical issue that was read across the nation as an invitation to come to San Francisco and be a man's man." The article also included an interview with Bill Ruquy, part owner of the bar, who detailed the strict dress code that excluded tennis shoes among other garments that didn't fit the biker aesthetic. Especially for queer men living in conservative small towns, the publication shed a spotlight on this gay subculture of butch leathermen, who did not fit the widespread clichés of the 'effeminate homosexual'—and where to find them. Thus, the Life piece unintentionally became an advertisement for the leather scene and ultimately a catalyst of gay emancipation. Drummer magazine dedicated an article about the demolition of the Tool Box in its second volume in August 1975, titled "Requiem for a toolbox". This further illustrates the importance that contemporaries awarded to the Tool Box's role in gay leather history.

DoorDash, Inc. is an American company that operates an online food ordering and food delivery platform. The company is based in San Francisco, California. It went public in December 2020 on NYSE and trades under the symbol DASH.With a 56% market share, DoorDash is the largest food delivery company in the United States. It also has a 60% market share in the convenience delivery category. As of December 31, 2020, the platform was used by 450,000 merchants, 20,000,000 consumers, and one million deliverers.DoorDash has been criticized and sued for withholding tips, reducing tip transparency, antitrust price manipulation, listing restaurants without permission, and allegedly misclassifying workers.

The California Institute for Regenerative Medicine (CIRM) was created in 2004 after 59% of California voters approved California Proposition 71: the Research and Cures Initiative, which allocated $3 billion to fund stem cell research in California. Institutes dedicated to stem cell research and training exist at Sanford Consortium, University of California, Santa Cruz, Stanford University, University of California Davis, University of California Irvine, University of California San Francisco, University of California Los Angeles and University of Southern California. Five “Alpha Stem Cell Clinics have also been established to lead clinical trials for stem cell therapies at City of Hope, University of California San Diego, University of California San Francisco, University of California Davis and a joint clinic at University of California Los Angeles and University of California Irvine.