The International Preparatory School

Kleinhans Music Hall is a concert venue located on Symphony Circle in Buffalo, New York. The hall "is renowned for its acoustical excellence and graceful architecture." Kleinhans is currently the home of the Buffalo Philharmonic Orchestra, a regular venue for the Buffalo Chamber Music Society, and is rented out for other performing groups and local events. The building was designed by father-and-son team Eliel Saarinen and Eero Saarinen, with help from local architects F. J. and W. A. Kidd, Stanley McCandless as lighting consultant, and Charles C. Potwin as acoustical adviser. Kleinhans has two performance spaces, as well as additional rooms for rehearsals or private events. It was declared a National Historic Landmark in 1989 for its architecture, 49 years after its completion.

Engine House No. 2 and Hook and Ladder No. 9, also known as Jersey Street Firehouse, is a historic fire station located at Buffalo in Erie County, New York.

The Zink Block is a historic commercial building located at Buffalo in Erie County, New York. It was built in 1896 for William T. Zink for his furniture sales and repair store. It is a five-story, brick building with a flat roof and Italian Renaissance Revival detailing. It sits on a stone foundation. The seven bay front facade features two stacked tripartite bay window units on the second through fourth floors.It was listed on the National Register of Historic Places in 2010.

The First Presbyterian Church in Buffalo, New York was the first organized religious body formed in what was then the western frontier of New York State. The town of Buffalo was sparsely populated when the church was organized on February 2, 1812. However, having survived the War of 1812, the town of Buffalo was rebuilt and rapidly grew with the completion of the Erie Canal in 1825. The first two buildings were located on the same downtown lot. However, the congregation relocated between 1889 and 1891 to its present location approximately one and-a-half miles to the north in a more residential area.

Holy Angels Church is located in the lower west side of Buffalo, New York, adjacent to D'Youville College. The parish has been served by the Oblates of Mary Immaculate from 1851-2020. In October 2020, D'Youville College purchased the Holy Angels Church, Rectory, and Convent.

Leonardo da Vinci High School is a high school in the lower west side of Buffalo, New York. There are 400 students enrolled in da Vinci spanning grades 9–12. The high school building is located on the D'Youville College campus. The school located at 334 Porter Avenue and serves Grades 9 through 12. The current principal is Gregory Lodinsky.

D'Youville University (D'Youville or DYU) is a private university in Buffalo, New York. It was founded as D'Youville College in 1908 and named by the Grey Nuns after the patroness saint Marie-Marguerite d'Youville. As of Fall 2020 D'Youville College serves 2,785 students (1,475 undergraduate, 1,310 graduate) and has 54 degree majors the health sciences, business, and liberal arts for undergraduate and graduate students. In February 2022, the New York State Board of Regents approved a name change to D'Youville University.

Fargo Estate Historic District is a national historic district located at Buffalo, Erie County, New York. The district encompasses 390 contributing buildings, 1 contributing site, and 2 contributing objects on the Lower West Side of Buffalo. This predominantly residential district developed between about 1850 and 1930, and includes notable examples of Italianate, Queen Anne, Colonial Revival, and American Craftsman style architecture. A 2 1/2-block section of the neighborhood was developed between about 1888 and 1910 on the former "Fargo Estate," the home of William Fargo. Located in the district are the separately listed Engine House No. 2 and Hook and Ladder No. 9 and a section of the Delaware Park-Front Park System (Porter Avenue). Other notable buildings include the Benedict House (c. 1890), Plymouth Methodist Episcopal Church / now Karpeles Library and Manuscript Museum (1912), and West Side Presbyterian Church / now Iglesia de Cristo Misionera (1882).It was listed on the National Register of Historic Places in 2016.

The Allentown district is a neighborhood in Buffalo, New York. The neighborhood is home to the Allentown Historic District.

Buffalo Tennis and Squash Club is a historic clubhouse building in Buffalo in Erie County, New York. It was built in 1915–1916 and is a 2+1⁄2-story, Classical Revival–style building with a hipped roof. It is constructed of hollow tile and is sheathed in stucco with brick quoins. The original building was enlarged with the addition of two doubles squash courts in 1929. A second tennis court was added in 1968.It was listed on the National Register of Historic Places in 2008. It is located in the Elmwood Historic District–West.

Elmwood Village is a neighborhood in Buffalo, New York.

A statue of Christopher Columbus by the sculptor Giovanni Polizzi formerly stood in Columbus Park, in Buffalo, New York.