University of Health Sciences and Pharmacy in St. Louis

Central West End station is a St. Louis MetroLink station. It is located in the Central West End neighborhood just southeast of the intersection of Euclid Avenue and Children's Place. This station serves the Washington University Medical Center, Barnes-Jewish Hospital and St. Louis Children's Hospital. Central West End is also a major bus transfer and is the most used station in the MetroLink system. In April 2021, Metro, in partnership with the Washington University School of Medicine and BJC HealthCare, completed a major upgrade to the station. The upgrade included a new glass canopy covering 60% of the platform, a glass elevator outside of the path of pedestrian travel, a WUSM welcome center at the Euclid level entrance and exit, the main stairwell was widened from 6 feet (1.8 m) to 10 feet (3.0 m), additional lighting and fencing was added, and the station aesthetic was modified to match adjacent hospital buildings.

The Washington University School of Dental Medicine (WUSDM) was the dental school of Washington University in St. Louis. It operated from 1866 to 1991. Over 5,000 dentists were educated at WUSDM. WUSDM was a pioneer in the practice of scientific dental education previously absent in the dental profession. The school was founded by the Missouri State Dental Society and dentist Henry E. Peebles as the Missouri Dental College in 1866. The first dean of the school was Homer Judd. It is the first dental school west of the Mississippi River and only the sixth dental school in the U.S. In 1892 the Missouri Dental College merged with Washington University in St. Louis, becoming the Dental Department of Washington University. In 1908 the first woman was admitted to study at the university. In 1928, Washington University School of Dental Medicine relocated to 4559 Scott Avenue at the Washington University School of Medicine campus.In 1958 the University launched the Baby Tooth Survey, led by Dr. Louise Reiss and with funding from the Greater St. Louis Citizen's Committee for Nuclear Information (CNI), which studied strontium-90 absorption of children by examining their deciduous teeth. During the 1970s the University began an experimental three-year DMD curriculum. In 1989 Wash U's board of trustees voted to close the School of Dental Medicine. The board said that the decision was based upon budget deficits, increasing tuition rates, competition from less-expensive state-funded dental schools, limited outside funding, and a declining student enrollment. By 1991 the Dental School graduated its 125th and final class.

The Masters and Johnson Institute (1964–1994) was the clinical and research foundation of sexologist duo Masters and Johnson. Located in Saint Louis, Missouri, the institute was established to study human sexuality with particular emphasis on the anatomy and physiology of human sexual response and the diagnosis and treatment of sexual dysfunctions. Founded as the Reproductive Biology Research Foundation, the organization changed its name to the Masters and Johnson Institute in 1978; it closed in 1994.

Goldfarb School of Nursing at Barnes–Jewish College is a college of nursing located in St. Louis. It has one campus: located at Washington University's Medical School and Barnes-Jewish Hospital campus.

Barnes-Jewish Hospital is the largest hospital in the U.S. state of Missouri. Located in the Central West End neighborhood of St. Louis, it is the adult teaching hospital for the Washington University School of Medicine and a major component of the Washington University Medical Center. In 2022, Barnes-Jewish was named one of the top twenty hospitals in the United States by U.S. News & World Report in its annual ranking.

Mainlander is a restaurant in St. Louis, Missouri. It was a semifinalist in the Best New Restaurant category of the James Beard Foundation Awards in 2024.

Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis, a private research university with its main campus in St. Louis County, and Clayton, Missouri. Founded in 1891, the School of Medicine shares a campus with Barnes-Jewish Hospital, Alvin J. Siteman Cancer Center, and Central Institute for the Deaf. It has consistently ranked among the top medical schools in the United States in terms of the number/amount of research grants/funding awarded by the National Institutes of Health, among other measures.The clinical service is provided by Washington University Physicians, a comprehensive medical and surgical practice providing treatment in more than 75 medical specialties. Washington University Physicians are the medical staff of the two teaching hospitals – Barnes-Jewish Hospital and St. Louis Children's Hospital. They also provide inpatient and outpatient care at the St. Louis Veteran's Administration Hospital, hospitals in the BJC HealthCare system and 35 other office locations throughout the greater St Louis region.

The Washington University Medical Center (WUMC), located in St. Louis, Missouri, is a large scale health-care focused commercial development located in St. Louis' Central West End neighborhood. The Washington University Medical Center Redevelopment Corporation focuses on developing public-private partnerships that promote infrastructure and housing development in the WUMC area. As of 2017, the executive director of WUMCRC is Brian Phillips. Although many of the institutions are affiliated with Washington University in St. Louis, most of the institutions of WUMC are independent of the university. Notably, the medical center is anchored by Barnes-Jewish Hospital and also houses the Washington University Medical School.

St. Louis Children's Hospital is a dedicated pediatric hospital in St. Louis, Missouri, and has a primary service region covering six states. As the pediatric teaching hospital for Washington University School of Medicine, St. Louis Children's Hospital offers nationally recognized programs for physician training and research. The hospital has 402 licensed beds, 3,423 employees, 881 physician staff members, and 1,300 auxiliary members and volunteers. The hospital treats infants, children, teens, and young adults aged 0–21.

The Forest Park Hotel is a six-story building located in the Central West End neighborhood of St. Louis, Missouri and listed on the National Register of Historic Places. The six-story building was built in 1923 and is made of reinforced concrete with red brick curtain walls trimmed with terra cotta. Following the early success of the hotel, a seven-story addition was built in 1926 that closely follows the design of the original building. A one-story stone and glass addition was added to the building's northeast corner in the 1960s. The original building was designed by Preston J. Bradshaw, a prominent St. Louis architect who also designed the nearby Chase Park Plaza Hotel, Mayfair Hotel, Lennox Hotel, and Coronado Hotel. The center wing addition was designed by George D. Barnett, Jr. and includes several small private dining rooms of considerable architectural interest.The Forest Park Hotel was once famous for the Circus Snack Bar nightclub located in its ground floor retail space fronting Euclid Avenue. During the nightclub's heyday in the 1930s and 1940s, it was run by local hotelier and businessman Harold Koplar and hosted performers such as Liberace, Louis Armstrong, and Sarah Vaughan.In 1983, restaurateur Harold Butler, founder of the restaurant chain Denny's, bought the Forest Park Hotel and performed $7 million in renovations. Financial trouble, however, led to the building's sudden foreclosure and vacancy in December 1990.In 2003, a private development group renovated and converted the long dormant Forest Park Hotel for $20 million into a 115-unit apartment building.Two successful restaurant owners in the CWE recently signed a contract to open a new restaurant on the first floor of the hotel facing Euclid.

Central Institute for the Deaf (CID) is a school for the deaf that teaches students using listening and spoken language, also known as the auditory-oral approach. The school is located in St. Louis, Missouri. CID is affiliated with Washington University in St. Louis.

McDonnell Genome Institute (The Elizabeth H. and James S. McDonnell III Genome Institute) at Washington University in St. Louis, Missouri, is one of three NIH funded large-scale sequencing centers in the United States. Affiliated with Washington University School of Medicine and the Alvin J. Siteman Cancer Center, the McDonnell Genome Institute is creating, testing and implementing new approaches to the study of genomics with the goal of understanding human health and disease, as well as evolution and the biology of other organisms.