Buenaventura Garcia Paredes, O.P. Building

The Thomas Aquinas Research Complex (TARC) is the main venue for research in the University of Santo Tomas in Manila, Philippines. The building houses several research centers, laboratories, and the UST Graduate School.

Dr. Jose Fabella Memorial Hospital, the National Maternity Hospital, is a maternal and newborn tertiary hospital located in Santa Cruz, Manila in the Philippines. It also houses the Jose Fabella Memorial Hospital School of Midwifery, one of the best performing institutions recognized by the Professional Regulation Commission in the Midwife Licensure Examinations. In 2015, the World Health Organization recognized the hospital "as a role model of the World Health Organization-Western Pacific Region Office for its essential newborn care programs, which have been proven to reduce infant morbidity and mortality".

The University of Santo Tomas Junior High School (USTJHS), formerly called University of Santo Tomas High School, was established on June 6, 1928, and is one of the junior high school departments of the University of Santo Tomas (UST), located at Sampaloc, Manila, Philippines. USTJHS offers four years of high school, starting from Grade 7 to 10. The remaining two years of high school (Grade 11 and Grade 12) are available at the University of Santo Tomas Senior High School.

The University of Santo Tomas Athletic Field and Open Spaces, located at the University of Santo Tomas in Manila, is a National Cultural Treasure as declared by the National Museum of the Philippines.

The Miguel de Benavides Library, also known as the University of Santo Tomas Library, is the main academic library of the University of Santo Tomas. The library has been in continuous service and its collection antedates the existence of the university itself.

The Henry Sy Sr. Hall is an academic and research building of the University of Santo Tomas in Manila, Philippines. It houses the Saints Cosmas and Damian Center for Simulation and Research of the Faculty of Medicine and Surgery. It is named after the founder of the SM Investments, Henry Sy.

The University of Santo Tomas College of Commerce and Business Administration is the business school of the University of Santo Tomas in Manila, Philippines. The college offers programs in Financial Management, Marketing Management, Human Resources Development Management, Business Economics, and Entrepreneurship. The college is one of the first business schools in the Philippines.

The University of Santo Tomas in Manila, Philippines marks a variety of traditions largely influenced by the Spanish and Filipino Dominican culture. Many are annual events, such as religious assemblies marking the start and end of the academic year, a "welcome walk" for new students, as well as intercollege sport competitions and talent exhibitions. Christmas is celebrated in a month-long festivities culminated by the UST Paskuhan. Many Roman Catholic feast days are also celebrated.

The Archives of the University of Santo Tomas (AUST), also known in Spanish as the Archivo de la Universidad de Santo Tomas, is located at the Miguel de Benavides Library in Manila. The AUST is the central repository of historical and rare documents pertaining to, but not exclusively, to the history of the University of Santo Tomas, one of the oldest existing universities in Asia, and the oldest institution of higher learning in the Philippines. The collections consist of historical documents such as Papal bulls, royal decrees, rare Filipiniana prints, historical treatises, addresses, sermons, novenas, catechisms in many Philippine languages, national periodicals, and academic records of all educational institutions in the Philippines during the Spanish period. The archives is also home to the only incunabula, or books printed before 1500, in the country.Aside from having one of the largest collection of 15th-, 16th-, 17th-, and 18th-century European manuscripts in Asia, the archives also boasts of possessing the biggest collection of extant ancient baybayin scripts in the world.

The Afable building is a 3-storey structure in Manila. It is located on a trapezoidal lot at the corner of Nicanor Reyes st. (previously Morayta st.) and Lerma St. facing España Boulevard. The building possesses a façade both from its original design in 1932 (Lerma side) and the post war renovation in 1960 (Nicanor Reyes side) both designed by Filipino architect Pablo Antonio Sr. who is well known for Art Deco and later on became a National Artist in Architecture in 1976. Possibly the oldest still standing work of Pablo Antonio Sr. as of 2016.

The University of Santo Tomas Museum of Arts and Sciences is the oldest existing museum in the Philippines. It started as a Gabinete de Fisica, or observation room, of mineral, botanical and biological collections in the 17th century. Under the old Spanish educational law the collections were used as classroom materials, especially in Medicine and Pharmacy.

Santo Tomas Internment Camp, also known as the Manila Internment Camp, was the largest of several camps in the Philippines in which the Japanese interned enemy civilians, mostly Americans, in World War II. The campus of the University of Santo Tomas in Manila was utilized for the camp, which housed more than 3,000 internees from January 1942 until February 1945. Conditions for the internees deteriorated during the war and by the time of the liberation of the camp by the U.S. Army many of the internees were near death from lack of food.