Axa Towers

Plymouth Congregational Church is located on East Onondaga Street in Syracuse, New York. It was designed in 1858 by Horatio Nelson White in the Romanesque Revival style. The founding congregation was closely associated with the abolitionist movement in Syracuse. It was listed on the National Register of Historic Places in 1997.

The Diocese of Syracuse (Latin: Diœcesis Syracusensis) is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church in Upstate New York in the United States. Its episcopal see is located in Syracuse. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of New York. On June 4, 2019, Pope Francis appointed Douglas Lucia to be the next Bishop of Syracuse. Lucia was consecrated to the episcopacy and installed as bishop on August 8, 2019.

The Marriott Syracuse Downtown is a historic hotel located at 100 E. Onondaga St., Syracuse, New York. It was built in 1924 as the Hotel Syracuse and was completely restored in 2016, when it joined the Marriott chain.

The Upstate Medical University Arena (originally known as Onondaga County War Memorial and later as the Oncenter War Memorial Arena) is a multi-purpose arena located in Syracuse, New York. It is part of the Oncenter Complex. Designed by Edgarton and Edgarton and built from 1949 through 1951, the structure is significant as an example of a World War I, World War II and Aroostook War commemorative and as "an early and sophisticated example of single-span thin-shell concrete roof construction." It was listed on the National Register of Historic Places in 1988. The Upstate Medical University Arena has been renovated twice, in 1994 and 2018.

The Cathedral of the Immaculate Conception in Syracuse, New York is the mother church of the Roman Catholic Diocese of Syracuse. It is the seat of the Bishop of Syracuse, currently Douglas Lucia.

Columbus Circle is a neighborhood and plaza in the downtown section of Syracuse, New York, United States. At the center of the circle is a large fountain and the Columbus Monument, designed by the Syracuse-born architect Dwight James Baum and dedicated in 1934. Columbus Circle is home to Syracuse's two cathedrals, the Episcopalian St. Paul's Cathedral and the Roman Catholic Cathedral of the Immaculate Conception, as well as the Onondaga County Courthouse and the John H. Mulroy Civic Center. The circle, originally known as Library Circle and later as St. Mary's Circle, began as a chiefly residential district. Beginning in the early 20th century it slowly developed as government and commercial buildings were constructed. From 1913 to 1933 the circle played host to the cities annual tree lighting. After the Columbus Monument's dedication in 1934, it was the site of annual memorial services on Columbus Day as well as protests advocating for its removal. In October 2020 the city of Syracuse announced plans to remove the statue of Christopher Columbus and redevelop the circle into "Heritage Park." The removal was halted by a court decision in 2022, which the city successfully appealed.

The Montgomery Street–Columbus Circle Historic District is located in Syracuse, New York. It was added to the National Register of Historic Places in 1980.

The Oncenter is a three-building convention and entertainment complex in Downtown Syracuse, New York, United States. It is composed of a convention center, sporting arena, and theaters.

The Carnegie Building in Syracuse, New York, previously known as the Syracuse Public Library, is a historic Carnegie library on Montgomery Street at Jefferson Circle in downtown Syracuse. It was built by the City of Syracuse in 1905-06, and came into County of Onondaga ownership in 1976. The building served as a library for 83 years and was the main library of the Syracuse Public Library system, which merged with Onondaga County's library system in 1976 to become the Onondaga County Public Library System. As "Carnegie Library", it was listed on the National Register of Historic Places as a contributing building in the Montgomery Street–Columbus Circle Historic District in 1980. Following acquisition and renovation by the Carnegie Redevelopment Corp., a local development corporation, the building was leased by the Syracuse city school district for 15 years, from 1996 - 2012 when the school district chose not to renew its lease option. In 2019, after it had sat vacant for eight years, a proposal was floated to renovate it for $4.1 million to hold city and county planning and economic development offices and save on the city's rental costs. The plan was approved in 2021 and work began in 2022, but its current status is unknown as of July 2024.

Downtown Syracuse is the economic center of Syracuse, New York, and Central New York, employing over 30,000 people, and housing over 4,300. It is also one of the 26 officially recognized neighborhoods of Syracuse.

Central Technical High School, also known as Central Tech, is located on South Warren Street in Syracuse, New York. It was designed by Archimedes Russell, and built in 1900. At that time, it represented the latest in educational building design. Classes were first held in the school in 1903.The building has been closed since 1975.The school building was added to the National Register of Historic Places in 1981.Possible reuse of the building has been discussed several times. In 2019, plans are active to re-purpose the building as a science, technology, engineering, arts, and math school.

The Everson Museum of Art ( EE-vər-sən) in Downtown Syracuse, New York is a major Central New York museum focusing on American art.