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The Cathedral of Saint John the Baptist (Spanish: Catedral San Juan Bautista) is an Episcopal cathedral in San Juan, Puerto Rico. It is the seat of the Diocese of Puerto Rico and it is located in the Santurce district of San Juan.

Central High School is a school located in Santurce barrio of San Juan, Puerto Rico. The 1925-built building was listed on the U.S. National Register of Historic Places in 1987.It is a three-story, U-shaped building with Spanish Renaissance architecture.Its National Register nomination asserts that "Central High School is, for many reasons, the most important school structure built in Puerto Rico in the first decades of the XXth century."It was built as part of a building program that also yielded the Ponce High School, built in 1915, and the Gautier Benítez High School in Caguas, built in 1924.

The Instituto Loaiza Cordero para Niños Ciegos (lit., "Loaiza Cordero Institute for Blind Children"), also known as the Instituto Puertorriqueño para Niños Ciegos (lit., "Puerto Rican Institute for Blind Children"), is a former hospital and school complex for blind children and now a historic district located in the Santurce area of the city of San Juan, Puerto Rico. The historic district is located in a large urban block in the Figueroa subbarrio of Santurce, bound by the Avenida Manuel Fernández Juncos to the northeast, Avenida Hipódromo to the southeast, Las Palmas Street to the southwest and Figueroa Street to the northwest. The historic district was added to the National Register of Historic Places in 2018 due to its historical and architectural significance.It was designed by architect Joseph O'Reilly who worked closely with Loaiza Cordero herself. The namesake of the institute is Loaiza Cordero del Rosario, a partially blind educator, public servant and poet who was highly involved in the development, construction and management of the site. Native to Yauco, she was part of the first graduate class (1907) of the Normal Industrial School (Escuela Normal Industrial), one of the institutions that would later become the University of Puerto Rico. Loaiza Cordero became a schoolteacher afterwards, an endeavor that was cut short after finding herself partially blind. She was forced to resign from her position but later enrolled at a two-year program at the Perkins Institution for the Blind in Watertown, Massachusetts. This experienced motivated her to resume her education career and to bring education services to children in Puerto Rico. She soon lobbied in the Puerto Rican government for the creation of infrastructure for blind individuals in the island which resulted in the creation of several blind schools throughout the island and the then-called Puerto Rican Institute for Blind Children. The development of the institution was the first of its kind in Puerto Rico and one of the earliest of its kind in the United States that would bring pedagogical, architectural and urban planning ideas together. The complex was design to provide safety, comfort and mobility to blind children, evident in the use of Braille in both Spanish and English throughout the whole site. In addition to Joseph O'Reilly, engineers Manuel L. Miró and Demetrio del Valle were also involved in the construction of the complex according to a dedicative plaque located at the site today.The Loaiza Cordero Institute historic district designations consists of two contributing buildings (the former hospital and schoolhouse for blind children), a former park and playground also designed for blind children, an allée-like road that transverses the institutes and an ornamental fountain.

La Placita is a historic district and neighborhood of Santurce, San Juan, Puerto Rico, located in the former area of Santurce's old market square (Spanish: Plaza del mercado de Santurce) in Campo Alegre. La Placita today is a popular dining and nightlife destination in San Juan, while still functioning as a produce and food market during the day.

The Puerto Rico Museum of Contemporary Art, often abbreviated to MAC, is a contemporary art museum in Santurce, Puerto Rico.

Figueroa is one of the forty subbarrios of Santurce, San Juan, Puerto Rico.

Campo Alegre and Alto del Cabro are two subbarrios adjacent to each other with similar characteristics in the Barrio of Santurce. They have a combined land area of 0.28 square kilometres (0.11 sq mi) and a resident population of 2,106 as of the 2000 United States Census. They are located between Expreso Baldorioty de Castro to the north, Ponce de León Avenue to the south, Cerra Street to the west and Canals and Robles Streets to the east. These subbarrios, urbanized during the 19th century, are two of the oldest sections of Santurce. The perpendicular streets running north of Ponce de León Avenue are those corresponding to old toponymical alignments of the proprietors throughout Carretera Central.

The Luis A. Ferré Performing Arts Center (Centro de Bellas Artes Luis A. Ferré in Spanish) is a multi-use performance centre located in the barrio of Santurce in San Juan, Puerto Rico. It features three main concert and theater halls for plays, ballet, operas and concerts. It was renamed in 1994 after the late Puerto Rican philanthropist, politician and Governor of Puerto Rico, Luis A. Ferré. The Center opened on April 9, 1981 under the administration of Governor Carlos Romero Barceló after ten years of planning, project financing, and construction. Since then, it has become the most important performing arts venue in the Puerto Rican capital, presenting the highest level of commercial theater in Puerto Rico along with ballets and operas, and also hosting artists such as Plácido Domingo and Menudo. The center is home to the Puerto Rico Symphony Orchestra and the annual Casals Festival. In January 2019, Lin-Manuel Miranda’s musical Hamilton began its third touring production at the venue, with Miranda reprising the titular role of Founding Father and Secretary of Treasury, Alexander Hamilton, with higher praise than his original run on Broadway. Miranda returned to the venue after nine years since he reprised the role of Usnavi exclusively in San Juan during the North American touring production of In the Heights, which he also wrote.

Hipódromo is one of the forty subbarrios of Santurce, San Juan, Puerto Rico.

Condadito is the smallest of the forty subbarrios of Santurce, San Juan, Puerto Rico.

The Casals Festival is a classical music event celebrated every year in San Juan, Puerto Rico, in honor of classical musician Pablo Casals.

Edificio del Valle is a historic mixed-use building located at 1118 Ponce de León Avenue of Santurce in San Juan, Puerto Rico. It was built in 1941 by the Santurce Development Company and designed by famed Puerto Rican architect Rafael Carmoega, who also designed famous buildings such as the Capitol of Puerto Rico and the University of Puerto Rico clock tower among others. It is a five-story reinforced concrete structure with commercial and retail spaces on its ground level and 16 apartments in the rest. Edificio del Valle has a distinctive Spanish/Mission Revival-style, evident in many of Carmoega's works, with eclectic elements that reference both the local vernacular, Neoclassical and the Modernist styles of the period.