St. Patrick Hospital and Health Sciences Center

The St. Francis Xavier Church in the Downtown district of Missoula, Montana, is the tallest church in Missoula, and one of the tallest in the state (by height to roof). It is also the tallest church in Missoula County, Montana. It has paintings well over 100 years old, which were done by a brother of the Society of Jesus, a kitchen helper, who painted them in his spare time. It is located at 420 West Pine Street.

Mrs. Lydia McCaffery's Furnished Rooms, also known as the McCauley Lodging House and now known as the St. Patrick's House, is a former rooming house in Missoula, Montana. It is included in the Missoula Downtown Historic District. It is a two-and-one-half story American Foursquare house.

The Gleim Building, 265 W. Front St., Missoula, Montana, was a brothel constructed in 1893 for Mary Gleim, a notorious madam who owned at least eight "female boarding houses". This building serves as an example of a vernacular adaptation of Romanesque architecture.It was listed on the National Register of Historic Places in 1990.

Constructed in 1893, the Gleim II building at 255-257 West Front Street was built for madame Mary Gleim. While altered over the years, it was restored in the 1990s, and retains Italianate features such as the brick corbelling along the top front. Along with the nearby Gleim Building, Gleim II was built of brick, replacing a prior wooden structure. During the height of Missoula's Redlight District, it was one of eight brothels owned by Mary Gleim.

Zip Auto, at 251 W. Main St. in Missoula, Montana, was built in 1937 and was listed on the National Register of Historic Places in 1990.It was designed by Missoula architect H. E. Kirkemo. It is an Art Moderne-style L-shaped one-story flat-roofed poured concrete structure with four garage bays.

The Missoula County Courthouse is located in Missoula, Montana, in the center of Downtown Missoula. It is located at 200 West Broadway, Missoula Montana. It was added to the National Register of Historic Places listings on September 1, 1976.It is a two-story building on an elevated basement, with walls of native sandstone. It was designed by Missoula architect A.J. Gibson and built during 1908-10 by Spokane contractor Williams & Oliver Co. on the site of the previous county courthouse.

The Palace Hotel is a building located in Downtown Missoula, Montana. Built in 1909, it became one of Missoula's first multi-story hotels. Today, the building houses apartments. Its architectural style is Renaissance revival. The building was added to the National Register of Historic Places in 1982.

The Garlington Building is a building in Downtown Missoula, Montana. It is located at the 350 Ryman St. The building is a postmodern design. The building's abbreviated name is the GLR Building. It was the first project in Montana financed with federal New Markets Tax Credits.

Downtown Missoula is the central business district in Missoula, Montana, and West-Central Montana. Downtown Missoula's rough boundaries are the Clark Fork River to its south, Madison St. to its east, the old U.S 93 highway/ North Orange St. to its west, and West Alder St. to its north, though parts south of the Clark Fork River are also at times mentioned. It is home to Ogren Park at Allegiance Field which is the venue for the Missoula PaddleHeads. Downtown is also home to several parks, and historic buildings such as the Wilma Building.

The First Security Bank is a low-rise building in the heart of Downtown Missoula, Montana. It is located at 100 East Broadway.

The Atlantic Hotel in Downtown Missoula, was listed on the National Register of Historic Places in 1990. The building has also been known as the Circle Square Second Hand Store, the business which it housed in 1990. It is a three-story brick building built in 1902. It has a stepped parapet with battlements.

The Hammond Arcade, at 101 S. Higgins Ave. in Missoula, Montana, was built in 1934. It was listed on the National Register of Historic Places in 1990.It includes aspects of Art Deco style. It is a one-story brick commercial building with five front bays and five bays facing north. It is topped by stepped, polychrome brick battlements.