Schoolhouse No. 6

St. Mark's Lutheran Church is a historic Lutheran church on Main Street in Guilderland Center, Albany County, New York. It was built in 1872 in a vernacular Italianate style. It has curved arched windows and a bracketed cornice. It features a square bell tower with pedimented cornice and steeple. St. Mark's served the Lutherans until 1973, when the town leased it as a community center. It was listed on the National Register of Historic Places in 1982.

Mynderse-Frederick House is a historic home and tavern located at Guilderland in Albany County, New York. It was built in 1802 and is a two-story frame house with rear ell in the Colonial style. It has a gable roof and features a recessed entrance with pilasters, transom and sidelights. It was adapted for use as a tavern in the 1840s and is now used as a local history museum.It was listed on the National Register of Historic Places in 1982.

Helderberg Reformed Dutch Church was a historic Dutch Reformed church at 140 Main Street in Guilderland, Albany County, New York. It was built in 1895 in a vernacular Late Gothic Revival style. The church burned and was demolished in 1986. The Reformed congregation which occupied the church was chartered in 1767. They erected a new church building in Guilderland Center in 1987. The original cornerstone of the historic church was laid into the edifice of this new church building. Helderberg Reformed Dutch Church was listed on the National Register of Historic Places in 1982.

Freeman House is a historic home located at Guilderland in Albany County, New York. The original house (the center and eastern section) was built about 1734; a western addition was built about 1750; and a rear ell was added about 1800. It is a two-story Dutch Colonial house with a gable roof and built of large, smooth finished beams. It is one of the finest and oldest colonial period buildings in Guilderland, and may be the oldest frame house in Guilderland. Following the American Revolution, the home belonged to Revolutionary War veteran Barent Mynderse.When photographer Nelson E. Baldwin photographed the house in 1937 as part of the Historic American Buildings Survey, it was covered in a synthetic brick siding, which has since been removed. A historic marker stands in front of the house.It was listed on the National Register of Historic Places in 1982.

Guilderland Center is a hamlet in the town of Guilderland, Albany County, New York, United States. The hamlet lies along New York Route 146 and the Black Creek, a tributary of the Normans Kill.

Guilderland High School is a public senior high school, located in Guilderland Center, New York. It is part of the Guilderland Central School District. Constructed in 1953, the high school has since undergone additions in 1955, 1960, 1997, 2010, and 2021. Originally, the building functioned as a Junior-Senior High School, but after the construction of Farnsworth Middle School in 1970, the district divided the schools into two. As a school, Guilderland High School's enrollment jurisdiction also includes the village of Altamont, NY and the North Bethlehem neighborhood of Bethlehem, NY. Currently, the school runs on block scheduling.

The Apple Tavern in Guilderland, New York was built in 1760 (or 1765). It was listed on the National Register of Historic Places in 1982. The listing included four contributing buildings on a 6.3-acre (2.5 ha) area. The tavern was built in 1760 (or 1765) on what was, or became, the Schoharie Turnpike or Schoharie Road or Old Schoharie Road. Its original owners were owners Hendrick (Henry) Appel and his wife, Eve. It was renovated significantly in the 19th century. In 1803 it was the site of meeting to form the town of Guilderland.In the 1980s and later it has been operated as a bed and breakfast, antique shop, and wedding and event venue known as the Appel Inn.

Fuller's Tavern is a historic inn and tavern located at Guilderland in Albany County, New York. It was built about 1795 and is a two-story wood-frame house with a "saltbox" roof. It opened as a tavern house in 1806 and is one of the few remaining inns of those built along the Great Western Turnpike in the late 18th century.It was listed on the National Register of Historic Places in 1982.

Guilderland Cemetery Vault is a historic burial vault located in Guilderland Cemetery at Guilderland in Albany County, New York. It was built in 1872 and is a small one story cobblestone building. It is built of coursed cobblestones with smooth ashlar quoins and rounded arch door.It was listed on the National Register of Historic Places in 1982.

French Mills, or French's Mills, was the site of a sawmill, which started making clothes in 1795 under its owner Peter K. Broek. It was sold to Abel French in 1800 and became a tavern that same year under Jacob Aker. It is located in Guilderland Center, New York. It is unrelated to the French Mills that United States military forces retired to after the Battle of Crysler's Farm during the War of 1812. Among the notable individuals from French Mills was James H. Blessing, who was born there and served as mayor of Albany, New York from 1900 to 1901.

Houck Farmhouse is a historic home located at Guilderland in Albany County, New York. It was built circa 1850 and is a two-story frame farmhouse with a 1+1⁄2-story ell in the Greek Revival style. The ell features eyebrow windows and has an enclosed pedimented portico.It was listed on the National Register of Historic Places in 1982.

Van Patten Barn Complex is a historic barn complex located at Guilderland in Albany County, New York. The complex consists of a dutch barn built about 1700 and two English barns built about 1830.It was listed on the National Register of Historic Places in 1982.