Ruins of Saint Paul's

The Na Tcha Temple (Portuguese: Templo Na Tcha; Chinese: 大三巴哪吒廟), built in 1888, is a Chinese folk religion temple in Santo António, Macau, China. It is dedicated to the worship of the popular Deity Na Tcha (哪吒) or Sam Tai Tsz (三太子).

The Macao Museum (Chinese: 澳門博物館; Portuguese: Museu de Macau) is a public museum located on the hill of the Fortaleza do Monte in Santo António, Macau, China. The museum presents the history of the city and territory of the former Portuguese colony of Macau, now a Special Administrative Region of the People's Republic of China. Planning for the museum started in April 1995, its construction began in September 1996. The museum was inaugurated on 18 April 1998. The museum building is located within the interior of the Fortaleza do Monte. Its total size is about 2,800 m2, with around 2,100 m2 of exhibition space.

The Fortaleza do Monte (Portuguese for Mount Fortress, also Monte Forte; officially Fortaleza de Nossa Senhora do Monte de São Paulo, in English: Fortress of Our Lady of the Mount of St. Paul; Chinese: 大砲台; Cantonese Yale: daaih paau yìh) is a fort in Santo António in Macau. It is the historical military centre of Macau. The fort forms part of the "Historic Centre of Macau" and is a UNESCO World Heritage Site.The fort was built between 1617 and 1626 on the 52-metre tall Mount Hill, located directly east of the Ruins of Saint Paul's. It was constructed to protect the properties of the Jesuits (mainly Portuguese Jesuits) in Macau, especially from pirates. Later, the fort was taken over by the Portuguese colonial governor and the relevant authorities for the defence of Macau. The fort occupies an area of roughly 8,000 square metres. Thirty-two muzzle-loading cannon were placed around the fort's walls, and the two corners of the southeastern fort wall have small watchtowers. The fort proved crucial in successfully holding off the attempted Dutch invasion of Macau in 1622.The fort remained a restricted military area until 1965 when the barracks in the fort were converted into a weather observatory and the fort was opened to the public. The observatory ceased its function and was relocated to Taipa in 1996 before it was demolished to make way for the Museum of Macau, which was officially opened on 19 April 1998. The tree-covered park at the top of the fort has a panoramic view of the mainland area of Macau. Apart from being a fortress, it has served various functions: The first residence of the governors of Macau (in 1623 and in 1740). The base for two companies of the Portuguese Prince Regent Battalion to act as a police force from 1810 to 1841. A weather observatory of the Meteorological Department of Portuguese Macau (from 1966 to 1996). The Museum of Macau (1998 to present).

Kiang Wu Hospital (KWH; Chinese: 鏡湖醫院) is a private district general hospital is located in Santo António, Macau. It is one of the three hospitals in Macau. Founded in 1871, the hospital is run by the Kiang Wu Charitable Association and offered Chinese medical services. Renowned doctor Sun Yat-Sen brought Western medicine services to the hospital. The hospital has had four different sites, the last built in 2000. Till 2019 there was no Western-style medical school in Macau, so all indigenous intending doctors have to either qualify overseas, or qualified doctors have to be brought in from outside. Macau University of Science and Technology started a medical school in Macau in September 2019 for its MBBS program. The second batch of students started their classes on 21 September 2020. Clinical training of medical students will start from third year of medical training in the university hospital associated with the university. The medical school has been listed in the world directory of medical schools. Medium of instruction in the medical school is English. Most of the students are from Macau. The duration of MBBS course is 5 years with an additional year for internship. The hospital is not currently engaged in international healthcare accreditation.

The Old Protestant Cemetery (Chinese: 基督教墳場; Portuguese: Cemitério Protestante) is a cemetery in Santo António, Macau, China. It was established by the British East India Company in 1821 in Portuguese Macau in response to a lack of burial sites for Protestants in the Roman Catholic Portuguese colony. It is the last resting place of the artist George Chinnery, missionaries Robert Morrison and Samuel Dyer (his wife Maria is buried at the Old Protestant Cemetery in Penang), Royal Navy captain Henry John Spencer-Churchill (son of the 5th Duke of Marlborough and great-great-granduncle of Winston Churchill) and US Naval Lieutenant Joseph Harod Adams (grandson of the second president of the United States, John Adams, and nephew of the sixth, John Quincy Adams). Humphrey Fleming Senhouse, a captain in the Royal Navy, is also buried here, as is John Robert Morrison, son of Robert Morrison, who was appointed as Acting Colonial Secretary of Hong Kong but died eight days later in Macau from fever. William Napier, 9th Lord Napier was buried in the cemetery but his body was subsequently exhumed and reburied in Scotland. Another grave is that of Anders Ljungstedt, a prosperous Swedish businessman, interpreter and historian.In 2005, the cemetery was officially enlisted as part of the UNESCO World Heritage Site Historic Center of Macau.

Morrison Chapel (Portuguese: Capela Protestante; Chinese: 馬禮遜教堂), also known as Morrison Protestant Chapel, is an Anglican chapel situated in Luís de Camões Square, Santo António, Macau. Originally built in the early 19th century to serve the spiritual needs of the employees of East India Company, the chapel now serves the worshipers with a variety of denominational backgrounds in the Missionary Area of Macau. The present chapel was built in 1922.

Saint Dominic's Church (Chinese: 板樟堂; Portuguese: Igreja de São Domingos) is a late 16th-century Baroque-style church that serves within the Cathedral Parish of the Roman Catholic Diocese of Macau. It is in the peninsular part of the city at the Largo de São Domingos, near the Leal Senado Building. It was finished in 1587 and overseen by three Spanish Dominican priests. Due to renovations and reconstruction, the current structure dates from the early 17th century. It is one of 29 sites forming the Historic Centre of Macau, a UNESCO World Heritage Site.

The Casa Garden (Chinese: 東方基金會會址) is a small parkette located in Santo António, Macau, China. The area is the headquarters of the Macau delegation of the Orient Foundation.

Luís de Camões Garden (Chinese: 白鴿巢公園, Portuguese: Jardim de Luís de Camões) is a public park in Santo António, Macau, located next to the Church of Santo António. It is the oldest park in the territory, covering 20,000 square metres (220,000 sq ft) of space. Camões Grotto is the former home of 16th century Portuguese poet Luís de Camões and one time Macau resident. Years later, the British East India Company bought the mansion and established its headquarters there. The facility includes the Macao Public Library Wong Ieng Kuan Library in Luís de Camões Garden (Biblioteca de Wong Ieng Kuan no Jardim Luís de Camões Garden; 白鴿巢公園黃營均圖書館)

The Lou Kau Mansion (traditional Chinese: 盧家大屋; simplified Chinese: 卢家大屋; pinyin: Lújiā Dàwū; Portuguese: Casa de Lou Kau) is a historical house in Sé, Macau, China. Built in 1889, the mansion is one of the designated historical sites in the Historic Centre of Macau, a UNESCO World Heritage Site.

The Heritage Exhibition of a Traditional Pawnshop Business (Chinese: 典當業展示館; Portuguese: Espaço Patrimonial uma Casa de Penhores Tradicional) is a public museum in Sé, Macau, China.

Hotel Central (Chinese: 新中央酒店) is an 11-storey hotel on Avenida de Almeida Ribeiro in Sé, Macau. Historically it has also been known as President Hotel (Chinese: 總統酒店). The building was 6 storeys tall in 1928 but, after 5 more floors were added in 1942, became the tallest building in Macau. There were formerly casinos on the fifth and seventh floors of the building. It is also the first building in Macau with elevators.