John Crerar Library

The Pritzker School of Medicine is the M.D.-granting unit of the Biological Sciences Division of the University of Chicago. It is located on the university's main campus in the historic Hyde Park neighborhood of Chicago and matriculated its first class in 1927. The medical school offers a full-time Doctor of Medicine degree program, joint degree programs, graduate medical education, and continuing medical education.

The George Herbert Jones Laboratory is an academic building at 5747 S. Ellis Avenue, Chicago, Illinois, on the main campus of the University of Chicago. Room 405 of the building was named a National Historic Landmark in 1967; it was the site where plutonium, the first man-made element, was isolated and measured.

The University of Chicago Comer Children's Hospital (UC CCH) formerly University of Chicago Children's Hospital is a nationally ranked, freestanding, 172-bed, pediatric acute care children's hospital adjacent to University of Chicago Medical Center. It is affiliated with the University of Chicago Pritzker School of Medicine and is a member of the UChicago health system, the only children's hospital in the system. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Chicago and features an ACS verified level I pediatric trauma center. Its regional pediatric intensive-care unit and neonatal intensive care units serve the Chicago region.

The University of Chicago Medical Center (UChicago Medicine) is a nationally ranked academic medical center located in Hyde Park on the South Side of Chicago. It is the flagship campus for The University of Chicago Medicine system and was established in 1898. Affiliated with and located on The University of Chicago campus, it also serves as the teaching hospital for Pritzker School of Medicine. Primary medical facilities on campus include the Center for Care and Discovery, Bernard A. Mitchell Hospital, and Comer Children's Hospital. In 2019, U.S. News and World Report ranked UChicago Medicine the second-best hospital in both Chicago and Illinois behind Northwestern Memorial Hospital.

Amos Jerome Snell Hall and Charles Hitchcock Hall, more commonly known as Snell–Hitchcock (colloquially Snitchcock) or The Dorm For All The Goofy Nerds, make up a residence hall at the University of Chicago. The dorm is on the northwest corner of the University's main quadrangles at the corner of 57th St. and Ellis Avenue. It is connected via emergency exits to Searle Chemistry Laboratory. Built in 1892 (Snell) and 1901 (Hitchcock), they are the oldest residence halls still in use as such on the university's campus. Snell is built in a Collegiate Gothic style, while Hitchcock is Prairie Style-inspired Gothic. The buildings feature fireplaces and exteriors of limestone, as well as hardwood molding and trim. Snell–Hitchcock is known for having a high level of community spirit and involvement, which are best displayed at the annual University of Chicago Scavenger Hunt. As of 2015, the Snell–Hitchcock team has won 14 of the 29 hunts to date, and holds the longest winning streak (four years) in the history of the game.Hitchcock House's mascot is the armadillo. Snell House's mascot is the tortoise, after being recently changed from a monkey.

The Institute for Nuclear Studies was founded September 1945 as part of the University of Chicago with Samuel King Allison as director. On November 20, 1955 it was renamed The Enrico Fermi Institute for Nuclear Studies. The name was shortened to The Enrico Fermi Institute (EFI) in January 1968. Physicist Enrico Fermi was heavily involved in the founding years of the institute, and it was at his request that Allison took the position as the first director. In addition to Fermi and Allison, the initial faculty included Harold C. Urey, Edward Teller, Joseph E. Mayer, and Maria Goeppert Mayer.

The Joe and Rika Mansueto Library is the newest library of the University of Chicago, named after alumni Joe Mansueto and Rika Mansueto. The library has a capacity of 3.5 million volumes under an elliptical dome. It was designed by Helmut Jahn.

Chicago Pile-1 (CP-1) was the world's first artificial nuclear reactor. On 2 December 1942, the first human-made self-sustaining nuclear chain reaction was initiated in CP-1, during an experiment led by Enrico Fermi. The secret development of the reactor was the first major technical achievement for the Manhattan Project, the Allied effort to create atomic bombs during World War II. Developed by the Metallurgical Laboratory at the University of Chicago, it was built under the west viewing stands of the original Stagg Field. Although the project's civilian and military leaders had misgivings about the possibility of a disastrous runaway reaction, they trusted Fermi's safety calculations and decided they could carry out the experiment in a densely populated area. Fermi described the reactor as "a crude pile of black bricks and wooden timbers".The reactor was assembled in November 1942, by a team that included Fermi, Leo Szilard (who had previously formulated an idea for non-fission chain reaction), Leona Woods, Herbert L. Anderson, Walter Zinn, Martin D. Whitaker, and George Weil. The reactor used natural uranium. This required a very large amount of material in order to reach criticality, along with graphite used as a neutron moderator. The reactor contained 45,000 ultra-pure graphite blocks weighing 360 short tons (330 tonnes), and was fueled by 5.4 short tons (4.9 tonnes) of uranium metal and 45 short tons (41 tonnes) of uranium oxide. Unlike most subsequent nuclear reactors, it had no radiation shielding or cooling system as it operated at very low power – about one-half watt. The pursuit for a reactor had been touched off by concern that Nazi Germany had a substantial scientific lead. The success of Chicago Pile-1 provided the first vivid demonstration of the feasibility of the military use of nuclear energy by the Allies, and the reality of the danger that Nazi Germany could succeed in producing nuclear weapons. Previously, estimates of critical masses had been crude calculations, leading to order-of-magnitude uncertainties about the size of a hypothetical bomb. The successful use of graphite as a moderator paved the way for progress in the Allied effort, whereas the German program languished partly because of the belief that scarce and expensive heavy water would have to be used for that purpose. The Germans had failed to account for the importance of boron and cadmium impurities in the graphite samples on which they ran their test of its usability as a moderator, while Leo Szillard and Enrico Fermi had asked suppliers about the most common contaminations of graphite after a first failed test and consequently ensured the next test would be run with one entirely devoid of them. As it turns out both boron and cadmium are strong neutron poisons. In 1943, CP-1 was moved to Red Gate Woods, and reconfigured to become Chicago Pile-2 (CP-2). There, it was operated for research until 1954, when it was dismantled and buried. The stands at Stagg Field were demolished in August 1957; the site is now a National Historic Landmark and a Chicago Landmark.

Nuclear Energy (1964–66) (LH 526) is a bronze sculpture by Henry Moore on the campus of the University of Chicago at the site of the world's first nuclear reactor, Chicago Pile-1. The first human-made self-sustaining nuclear chain reaction was created here on December 2, 1942.

University of Chicago Library is the library system of the University of Chicago, located on the university's campus in Chicago, Illinois, United States. It is the ninth largest academic library in North America, with over 11.9 million volumes as of 2019. The library also holds 65,330 linear feet of archives and manuscripts and 245 terabytes of born-digital archives, digitized collections, and research data.The library has borrowing privileges with several other archives, museums, and libraries in the Chicago area, including the Art Institute of Chicago Library, the Chicago History Museum, Fermilab, the Field Museum of Natural History, and the Newberry Library.The library was founded by president of the University of Chicago, William Rainey Harper, who set the course for Special Collections as a “working collection” in 1891. The library's collections are located in six sites: the Joseph Regenstein Library, the John Crerar Library, the D'Angelo Law Library, the Joe and Rika Mansueto Library, the Eckhart Library for mathematics and computer science, and the School of Social Service Administration Library.

The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois, United States. The university has its main campus in Chicago's Hyde Park neighborhood.The university is composed of an undergraduate college and four graduate research divisions, which contain all of the university's graduate programs and interdisciplinary committees. It has eight professional schools: the Law School; the Booth School of Business; the Pritzker School of Medicine; the Crown Family School of Social Work, Policy, and Practice; the Harris School of Public Policy; the Divinity School; the Graham School of Continuing Liberal and Professional Studies; and the Pritzker School of Molecular Engineering. The university has additional campuses and centers in London, Paris, Beijing, Delhi, and Hong Kong, as well as in downtown Chicago.University of Chicago scholars have played a major role in the development of many academic disciplines, including economics, law, literary criticism, mathematics, physics, religion, sociology, and political science, establishing the Chicago schools in various fields. Chicago's Metallurgical Laboratory produced the world's first human-made, self-sustaining nuclear reaction in Chicago Pile-1 beneath the viewing stands of the university's Stagg Field. Advances in chemistry led to the "radiocarbon revolution" in the carbon-14 dating of ancient life and objects. The university research efforts include administration of Fermi National Accelerator Laboratory and Argonne National Laboratory, as well as the Marine Biological Laboratory. The university is also home to the University of Chicago Press, the largest university press in the United States.The university's students, faculty, and staff include 99 Nobel laureates. The university's faculty members and alumni also include 10 Fields Medalists, 4 Turing Award winners, 52 MacArthur Fellows, 26 Marshall Scholars, 53 Rhodes Scholars, 27 Pulitzer Prize winners, 20 National Humanities Medalists, 29 living billionaire graduates, and 8 Olympic medalists.

The University of Chicago Extension Division Library School was one of the pioneering training programs for librarians in the United States. The library school was a section within the Extension Division's Class-Study Department. It closed in 1903 after receiving controversial criticisms from the American Library Association.