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The 116th Street station is a local station on the IRT Lexington Avenue Line of the New York City Subway. Located at the intersection of Lexington Avenue and 116th Street in East Harlem, it is served by the 6 train at all times, the <6> train during weekdays in the peak direction, and the 4 train during late nights. This station was constructed as part of the Dual Contracts by the Interborough Rapid Transit Company and opened in 1918. It was renovated in 2003.

East Harlem, also known as Spanish Harlem or El Barrio, is a neighborhood of Upper Manhattan in New York City, north of the Upper East Side and bounded by 96th Street to the south, Fifth Avenue to the west, and the East and Harlem Rivers to the east and north. Despite its name, it is generally not considered to be a part of Harlem proper, but it is one of the neighborhoods included in Greater Harlem.The neighborhood has one of the largest Hispanic communities in New York City, mostly Puerto Ricans, as well as Dominicans, Cubans and Mexicans. The community is notable for its contributions to Latin freestyle and salsa music. East Harlem also includes the remnants of a once predominant Italian community. The Chinese population has increased dramatically in East Harlem since 2000.East Harlem has historically suffered from many social issues, such as a high crime rate, the highest jobless rate in New York City, teenage pregnancy, AIDS, drug abuse, homelessness, and an asthma rate five times the national average. It has the second-highest concentration of public housing in the United States, behind Brownsville, Brooklyn. East Harlem is undergoing some gentrification, and in 2016 the city considered rezoning the area. East Harlem is part of Manhattan Community District 11, and its primary ZIP Codes are 10029 and 10035. It is patrolled by the 23rd and 25th Precincts of the New York City Police Department.

La Marqueta is a marketplace under the elevated Metro North railway tracks between 111th Street and 116th Street on Park Avenue in East Harlem in Manhattan, New York City. Its official address is 1590 Park Avenue. In its heyday in the 1950s and 1960s, over 500 vendors operated out of La Marqueta, and it was an important social and economic venue for Hispanic New York. The New York Times called it "the most visible symbol of [the] neighborhood." It has since dwindled in size.The market was originally an informal gathering place for pushcart vendors and other merchants, but since 1936 it has been officially sanctioned, and vendors rent their stalls from the city. It was once possible to buy food, traditional medicines, recordings of Latin music, and supplies for charms and curses at La Marqueta. It was also the meeting place for the neighborhood after urban renewal displaced countless small businesses, replacing them with only large scale housing. Today, three of the original five buildings that housed the market have been burned or torn down, and a fourth is shuttered. As of May 2008, only four vendors were operating out of the last building, but the number later increased, reaching ten in early 2011.The City of New York has repeatedly tried to revive La Marqueta but has failed to find a viable business model that also pleases local residents and politicians. The Harlem Community Development Corporation, a state-run economic development agency, has proposed a concept called La Marqueta Mile. In 2010, the proposal won the support of the Center for an Urban Future.In 2009, New York City Economic Development Corporation (NYCEDC) and the New York City Council issued a request for proposals for businesses to operate and maintain a 3,000 square foot commercial kitchen incubator in La Marqueta. In early 2011, HBK Incubates, a food business incubator run by Hot Bread Kitchen, opened in a space at La Marqueta that had been renovated with $1.5 million in New York City Council funds.

On March 12, 2014, an explosion occurred at 9:31 a.m. in the East Harlem neighborhood of Manhattan in New York City. The explosion leveled two apartment buildings located just north of 116th Street at 1644 and 1646 Park Avenue, killing eight people, injuring at least 70 others, and displacing 100 families. City officials initially pointed to a gas leak as the cause of the blast. In June 2015, the National Transportation Safety Board (NTSB) blamed the explosion on failures by Consolidated Edison and the city. The NTSB also agreed to review Whistleblower Gas Explosion Audit Findings from the 2009 Floral Park Queens gas explosion as part of their East Harlem Gas Explosion Investigation. The NTSB were unable to resolve these hazards found with merit by the New York State Public Service Commission (NYSPSC) and they remain a Public Safety Hazard today.

The 116th Street station was a local station on the demolished IRT Third Avenue Line in Manhattan, New York City. The outer tracks had two side platforms for local trains, and was built first. The center track was built as part of the Dual Contracts for express trains. This station closed on May 12, 1955, with the ending of all service on the Third Avenue El south of 149th Street.

The Church of St. Paul is a Roman Catholic parish church in the Roman Catholic Archdiocese of New York, located in the East Harlem neighborhood of Manhattan, New York City. The sixth parish established in New York City, it was designated a New York City Landmark on June 28, 2016.

The Church of Our Lady Queen of Angels is a former Roman Catholic parish church under the authority of the Roman Catholic Archdiocese of New York, located at 228 East 113th Street in Manhattan, New York City. The parish was established in 1886 and was staffed by the Capuchin Friars; the parish closed in 2007. The Archdiocese announced on January 19, 2007, the church's closure.

The 110th Street station is a local station on the IRT Lexington Avenue Line of the New York City Subway. Located in East Harlem at the intersection of 110th Street and Lexington Avenue, it is served by the 6 train at all times, the <6> train during weekdays in the peak direction, and the 4 train during late nights. This station was constructed as part of the Dual Contracts by the Interborough Rapid Transit Company and opened in 1918. It was renovated from 2002 to 2004.

Our Lady Queen of Angels Catholic Elementary School, commonly referred to as Queen of Angels School, is a Catholic elementary school located in the East Harlem neighborhood of Manhattan, New York City. The school was founded by the parish friars in 1892 and was originally staffed by the Sisters of St. Agnes. Today it is run by lay teachers and is administered by the Partnership for Inner-City Education in conjunction with the Archdiocese of New York. On 25 September 2015, Pope Francis visited Queen of Angels School as part of his New York stop in his papal visit to Cuba and the United States.

The 110th Street station was a station located on the Metro-North Railroad's Park Avenue Viaduct in East Harlem, Manhattan, New York City. The station was built by the New York Central & Hudson River Railroad as part of an agreement with the New York City government. It was located at Park Avenue and 110th Street.

The 111th Street station was a local station on the demolished IRT Second Avenue Line in Manhattan, New York City. It had three tracks and two side platforms. The next stop to the north was 117th Street. The next stop to the south was 105th Street. The station closed on June 11, 1940.

The CUNY Graduate School of Public Health & Health Policy (commonly known as the CUNY School of Public Health, or CUNY SPH) is a public American research and professional college within the borders of City University of New York (CUNY) system of colleges. The school is situated at 55 West 125th Street in Manhattan. CUNY SPH offers doctoral programs, master's programs, several certificates, and faculty memberships in many of CUNY's research centers and institutes. A core roster of over 50 full-time faculty is supplemented by additional faculty members drawn from throughout CUNY.