Wright Brothers Mule Barn

The Hamilton-Brown Shoe Factory was the first large scale industrial operation in Columbia, Missouri. It was built in 1906-1907 by the Brown Shoe Company, the largest shoe manufacture in the world at the time. It was the first plant built outside of St. Louis and was operational from 1907-1939 The building today has been converted into offices. The company was a large manufacturer of men's, women's and children's shoes. In 1888, the Hamilton-Brown Shoe Company built a factory at the northeast corner of 21st and Locust in a fading upper-class residential neighborhood in St. Louis. Already a force in St. Louis industry, the company doubled its sales between 1890 and 1900. By the early 20th century, Hamilton-Brown with six manufacturing facilities claimed world leadership in boots and shoes. At one time, the company was the largest shoe manufacturer in the world. Their product line brand included the "American Gentleman" and "American Lady". It was listed on the National Register of Historic Places in 2002.

Columbia College, also known as Columbia College of Missouri, is a private college based in Columbia, Missouri. Founded in 1851 as a nonsectarian college, it has retained a covenant with the Christian Church (Disciples of Christ) since its inception. In addition to its main campus, the college operates 34 "extended campuses" in 13 U.S. states and one in Cuba, with 18 of them on U.S. military bases. One third of Columbia's almost 10,000 students are associated with the U.S. military.

The Samuel H. and Isabel Smith Elkins House is a historic home in Columbia, Missouri. The home is located just north of Downtown Columbia, Missouri on 9th street and today contains an artisan glassworks. The large two-story brick residence was built about 1882 in the Italianate style.The property was placed on the National Register of Historic Places in 1996. It is located within the North Village Arts District.

The North Village Arts District is a neighborhood and arts district in Columbia, Missouri. It is located on the northeast side of Downtown Columbia, and is the city's main art gallery district and center for the visual arts. The neighborhood is also home to restaurants, bars, food trucks, housewares shops, theaters, and a distillery. Rose Music Hall, a popular music venue, is located on Park Avenue. There are several dance studios, including the Missouri Contemporary Ballet. The district hosts a monthly art crawl called "First Fridays".Wabash Station, a restored railroad station, is the headquarters and central hub of Columbia Public Transit. The station previously served the Columbia Terminal Railroad, which brought passengers and goods into Columbia throughout the 1900s. The railroad was the primary cause of the neighborhood's original industrial nature. Today, many of the district's businesses are located in renovated warehouses and industrial buildings. A former gas manufacturing site, now owned by Ameren, may be turned into public green space.Several buildings in the neighborhood are listed on the National Register of Historic Places, including Wabash Station, the Boone County Courthouse, Columbia National Guard Armory, Elkins House, First Christian Church, and McCain Furniture Store. Two National Historic Districts are partially within the neighborhood: the Downtown Columbia Historic District, and the North Ninth Street Historic District. The district is adjacent to Stephens College and Columbia College.

Columbia station is a historic train station and headquarters of Columbia Transit located in Columbia, Missouri. The building was constructed in 1909 as the terminus of the Columbia Branch of the Wabash Railroad (now Columbia Terminal Railroad). It is a one-story, H plan, Tudor Revival style building constructed of locally quarried rock faced ashlar cut stone. In 2007, the building underwent renovation and restoration and was expanded to accommodate offices for Columbia's public transportation. The project, costing over $2.5 million, was intended to make the station a multi-model transportation center. It was certified at the LEED (Leadership in Energy and Environmental Design) Silver Level, meaning it meets national standards for energy efficiency and sustainable construction. The station is the busiest bus stop in Columbia and served as a pickup point for Megabus until September of 2015.The property was listed on the National Register of Historic Places in 1979 as the Wabash Railroad Station and Freight House. It is located in the North Village Arts District.

The First Christian Church is a historic Disciples of Christ church located at 101 North Tenth Street in Columbia, Missouri. It was designed by T.N. Bell of Chicago, Illinois and built in 1893. It has a Richardsonian Romanesque style Sanctuary that includes a square bell tower, horizontal massing with contrasting high gables, round arches, heavy and highly textured stone work, and voussoir arches. The Education Building was designed by Eugene Groves and added in 1929. This is the second church building to stand at this site. The building is still a functioning church today. It was added to the National Register of Historic Places in 1991. It is located in the North Village Arts District.

The Kress Building, also known as Kress Wholesale Company Store and Mehornay Furniture Store, is a historic commercial building located in downtown Columbia, Missouri. It was built in 1910 for the S. H. Kress & Co., and remodeled in 1946 when it became Mehornay Furniture. It is a tall two-story, brick building with an open storefront topped by horizontal metal banding, that consists of large plate glass windows.: 5–6 It operated as a furniture store from 1946 until 1979-80. It was again renovated in 2005. Post-renovation it became the home of the Penguin Piano Bar in 2005 on the ground floor and Roxy’s in 2015 on the 2nd floor. Both went out of business in 2020 due to the closures during the covid-19 pandemic.It was listed on the National Register of Historic Places in 2005.

First Baptist Church is a historic Baptist church in Columbia, Missouri. In 1823, at the time of its founding, it was the first and only church in Columbia. The Church and its members have played a prominent role in civic and religious affairs in Missouri. The church's Georgian Revival style sanctuary sits conspicuously on Broadway in Downtown Columbia; it is the fourth church building and second at that location. Stephens College, formerly a baptist institution founded by church members, is across the street. First Baptist has both a traditional and contemporary Sunday services, and formerly hosted a Swahili-language congregation. The church is affiliated with the American Baptist Churches USA. In 2001, the congregation joined the Cooperative Baptist Fellowship and its longtime affiliation with the Southern Baptist Convention was ended. In 2004, the Odyssey Chamber Music Series was founded as part of a community outreach effort. In addition, the Plowman Chamber Music Competition, Columbia Handbell Ensemble, Esterhazy Quartet, and the University of Missouri School of Music utilize the sanctuary as a performance venue. William Jewell, namesake of William Jewell College in Liberty, Missouri, has been described as the leading force behind the creation of the church. The first meeting took place in the home of Charles Hardin, father of Charles Henry Hardin governor of Missouri.

The Central Dairy Building, also known as Downtown Appliance and Gunther's Games, is a historic commercial building located in downtown Columbia, Missouri. It was built in 1927, and enlarged to its present size in 1940. It is a two-story brick building with terra cotta ornamentation elaborate classical and baroque design motifs. Also on the property is a contributing brick warehouse, constructed about 1940.: 5  Today the building houses an appliance store and restaurants on the first floor and lofts on the second. It was listed on the National Register of Historic Places in 2005.

The McCain Furniture Store Building is a historic commercial building located in downtown Columbia, Missouri. It was built about 1930 for the S. H. Kress & Co., and remodeled in 1951. It is a two-story, brick building with a simple stepped parapet.: 5  Though it has hosted a variety of businesses since the closing of the original store, today it holds Plasma Biological Services. It was listed on the National Register of Historic Places in 2005. It is located in the North Village Arts District.

The Stephens College South Campus Historic District is a national historic district on the campus of Stephens College in Columbia, Missouri. It includes the historic core of Stephens College in Eastern Downtown Columbia, Missouri. The District includes Senior Hall, Hickman Hall, Columbia Hall, and Wood Hall.The district was added to the National Register of Historic Places in 2005.

The Coca-Cola Bottling Company Building, also known as the Kelly Press Building, is a historic commercial building located on Hitt Street in downtown Columbia, Missouri. It was built in 1935, and is a 1 1/2-story, Colonial Revival style brick building with a side gable roof with three dormers. It has a long one-story rear ell.: 5  Today it houses Uprise Bakery, Ragtag Cinema (an independent theatre and staple of Columbia's cultural scene), Ninth Street Video, and Hitt Records.It was listed on the National Register of Historic Places in 2006.