Jose V. Toledo Federal Building and United States Courthouse

Santa Ana Church (Spanish: Iglesia de Santa Ana), popularly known as Capilla de Santa Ana, is a historic 17th century Catholic church located in Old San Juan in San Juan, Puerto Rico.This often-missed church is located on Tetuan Street close to the Art Deco-style Banco Popular building. The church, one of the oldest in San Juan, is famous for its pink color, simple yet elegant interior design and its arches. According to historian Maria de los Angeles Castro the church might have been decorated with frescoes created by renown 18th century artist José Campeche. The church is open to visitors and still hosts religious services.

The United States Custom House (Spanish: Edificio de la Aduana de Estados Unidos), also known as the San Juan Custom House (Edificio de la Aduana de San Juan), is a historic custom house located at the marina of Old San Juan in the city of San Juan, Puerto Rico. The custom house is located at the site of the former main port of the city of San Juan, north of the former Spanish Arsenal of San Juan, and next to the Las Dársenas and Immigrants' Square (Plaza del Inmigrante) and the Jose V. Toledo Federal Building and United States Courthouse. The large two-storey custom house is considered by the NRHP to be a superb example of Spanish Colonial Revival architecture in Puerto Rico and the Caribbean. It is most notable for its size, its elaborate terracotta-ornamented central tower and its pink-colored exterior.

Puerto Rico Ilustrado/El Mundo Building (Spanish: Edificio El Mundo/Puerto Rico Ilustrado) is a historic Art Deco high-rise building located in the Old San Juan historic district of the city of San Juan, Puerto Rico. The building was erected in 1923 to serve as the headquarters of the El Mundo newspaper and the Puerto Rico Ilustrado magazine. The architecture of the building blends numerous styles that represent the conjunction of various artistic movements and architectural schools of the late 19th century and the early 20th century. It is located in a high-rise block that faces the elevated La Palma Bastion portion of the city wall of San Juan which, when observed from beyond, makes the building look taller than it is in reality. The building was added to the National Register of Historic Places in 1997 for its architectural and historic importance.

San Francisco, within Old San Juan, is one of the 7 subbarrios of San Juan Antiguo barrio in the municipality of San Juan in Puerto Rico. A historic church, the Church of Saint Francis of Assisi, is located in San Francisco.

The Plaza de Armas of San Juan is one of the main squares in San Juan, the capital of Puerto Rico. It is located on San José Street in Old San Juan, and was designed to serve as the original main square for the city. San Juan City Hall is located to the north of the square, while the Puerto Rico Department of State lies at the west. The square's main feature is a round fountain with four marble statues representing "The Four Seasons", originally placed in the four corners of the square, which had been commissioned in 1856 to the "motherland", to be placed in Paseo La Princesa esplanade in Old San Juan.

Edificio Patio Español (Spanish for 'building of the Spanish courtyard'), also known as La Filarmónica Building, is a mixed-use building located in the Old San Juan historic district of the city of San Juan, Puerto Rico. It was designed in a Spanish Mission Revival-style by civil engineer Eduardo Fossas López and built in 1937 with the purpose of refilling an emptied lot of the old city with a structure that resembled and referenced the Spanish Colonial architecture around it. This emptied lot was formerly the site of a meeting house for a group called Sociedad La Filarmónica ('Society of the Philharmonic'), a scholarly club that was founded by Manuel de Elzaburú and Alejandro Tapia y Rivera with the intention of promoting cultural activities in the city of San Juan. The Patio Español building was added to the National Register of Historic Places in 2005.

The Church of Saint Francis of Assisi (Spanish: Iglesia de San Francisco de Asís) is a historic Catholic parish church located in the San Francisco sub-barrio of Old San Juan in San Juan, Puerto Rico. The church has gone numerous transformations throughout its history and its original brick and masonry structure can still be admired. The church is also renown for its crypt which is opened to visitors and at some point it contained the remains of Puerto Rican Impressionist painter Francisco Oller.

San Juan City Hall (Spanish: Casa de la Alcaldía de San Juan, or just Alcaldía de San Juan) is the seat of government for the Autonomous Municipality of San Juan in Puerto Rico. The city hall is located in Old San Juan, in front of the Plaza de Armas and next to the Palace of the Royal Intendancy, which today hosts the Puerto Rico Department of State. The San Juan City Hall was built in stages from 1604 to 1789. It went through numerous additions and expansions throughout its history. Its current structure and façade by the square, inspired by the Casa de la Panadería in the Plaza Mayor of Madrid, dates to 1840 and was designed by architect Pedro García.

Albizu University is a private university with its main campus in San Juan, Puerto Rico, a branch campus in Miami, Florida, and an additional instructional location in Mayagüez, Puerto Rico. It focuses on psychology, health, education, and human services.

The Port of San Juan (Spanish: Puerto de San Juan) is a seaport facility located in the metropolitan area of San Juan, Puerto Rico. The "Port of San Juan" is the general name used to call various passenger and cargo facilities located in lands around the San Juan Bay (Bahía de San Juan). The port is composed of a total of sixteen piers, of which eight are used for passenger ships and eight for cargo ships. The port's facilities, in addition to, Luis Muñoz Marín International Airport and the Cataño Ferry "Lancha de Cataño" services, are property of the Puerto Rico Ports Authority. The bay and its docks are located along San Antonio Canal, a narrow navigable section of San Juan Bay lying south of Old San Juan and San Juan island, and north and west of the Puerto Rico Convention Center District and Isla Grande Airport. The municipalities of Cataño, Guaynabo and San Juan compose the south side of the bay and port.

Capilla del Cristo (Chapel of Christ), also called Capilla del Santo Cristo de la Salud is a small chapel / museum located in the Old San Juan Historic District of Puerto Rico. Built in the 18th century and saved from demolition in the 20th century, the structure has become a cultural icon of Puerto Rico. Most of the articles located at its altar are from 1753. Travel guides list Capilla del Cristo as one of the must-see places of Old San Juan.

The Department of State of Puerto Rico was created in July 1952 and is responsible of promoting the cultural, political, and economical relations between Puerto Rico, other jurisdictions of the United States and foreign countries.