M. Wile and Company Factory Building

Trico Plant No. 1 is a historic windshield wiper factory building located in Buffalo, New York. It is an example of a style of architecture sometimes referred to as the daylight factory, a style for which Buffalo is well known. The building was mostly constructed in the 1920s and 1930s of reinforced concrete and features curtain walls of metal sash windows and brick spandrels, although a portion of the plant incorporates an historic brewery building from the 1890s. It was the original home of Trico Products Corporation, the first manufacturer of windshield wipers, and was an important factory during a period when Trico was the largest employer in the city of Buffalo. The building is also known for once being the office of John R. Oishei (1886–1968), the company's founder and an industrialist who went on to become one of the most important philanthropists in the Buffalo Niagara Region. The Trico business continued to operate at the building until 1998, when, after having transferred most of its manufacturing facilities to Texas and Mexico, the company moved out of the building. In 2003, plans were developed and conditionally approved by the New York State Historic Preservation Office to reuse the building as a mixed residential and commercial structure. That developer subsequently died, and in 2007 the property was purchased by the Buffalo Niagara Medical Campus (BNMC). After sitting dormant for another four years, it was reported that BNMC planned demolition of about 95% of the building beginning on April 15, 2012 (saving only the brewery building). Meanwhile, community groups have called attention to BNMC's refusal to conduct an adaptive reuse study or evaluation process prior to demolition to assess the feasibility of building reuse.Trico Plant No. 1 was listed on the National Register of Historic Places in 2001.As of October 2019, large portions of the southernmost (1890-1937) sections of the building are being demolished; the remaining portions are being renovated into a mixed-use complex including a hotel and loft apartments. The building will essentially be separated into two halves.

The Buffalo Niagara Medical Campus (BNMC) is a medical center of health care, life sciences research and medical education institutions, co-located on 120 acres (49 ha) in Buffalo, New York. The BNMC was founded in 2001 by a consortium (including the University at Buffalo School of Medicine and Roswell Park Comprehensive Cancer Center). This project comprises one of the five "Strategic Investment Areas" that make up Buffalo, NY's Queen City Hub Plan, the city's strategic plan for urban redevelopment.

Roswell Park Comprehensive Cancer Center is a cancer research and treatment center located in Buffalo, New York. Founded by Roswell Park in 1898, the center was the first in the United States to specifically focus on cancer research. The center, which conducts clinical research on cancer as well as the development new drugs, provides advanced treatment for all forms of adult and pediatric cancer, and serves as a member of the National Comprehensive Cancer Network. Roswell Park Comprehensive Cancer Center is currently the only upstate New York facility to hold the National Cancer Institute designation of "comprehensive cancer center".The Roswell Park campus, spread out in 15 separate buildings of approximately two million square feet, occupies 28 acres (11 ha) on the 100-acre (40 ha) Buffalo Niagara Medical Campus (BNMC) in downtown Buffalo, and includes 1,500,000 square feet (140,000 m2) of space equally distributed between clinical programs and research/education functions. A separate hospital building, completed in 1998, houses a diagnostic and treatment center. The campus also includes a medical research complex as well as research and education focused spaces.

Saint Louis Roman Catholic Church is the oldest Catholic parish in Buffalo, New York. It was the first Catholic church built in Buffalo, and holds the title of "Mother Church of the Roman Catholic Diocese of Buffalo".

The Shea's 710 Theatre (originally known as the Studio Arena Theatre) is a theatre in Buffalo, New York. It was founded in the 1920s and briefly closed in 2008 citing $3 million in debt and laying off its staff. It was reopened as the 710 Main Theatre in 2012 and is managed by Shea's Performing Arts Center.

The Buffalo Theatre District in downtown Buffalo, New York, United States, is the center of Buffalo's theater scene and draws Broadway shows that are in preview stage or on tour. It is bounded roughly by Washington, Tupper, Pearl and Chippewa Streets.

Canalside, formerly known as Canal Side and Erie Canal Harbor, is the recreation of the western terminus of the Erie Canal in Buffalo, New York. Canalside is situated on the Buffalo River, where the area was historically home to the Seneca people. In the early 20th century, the predominantly Italian area known as Dante Place and Canal Street was subjected to the forces of urban renewal, and the canals were filled in and dense neighborhoods were razed. The Buffalo Skyway, Buffalo Memorial Auditorium and Niagara Thruway took its place, with parking lots interspersed. With the completion of Marine Midland Arena (now KeyBank Center) in 1996, the Memorial Auditorium stood vacant. Empire State Development Corporation created a master plan for an Erie Canal Harbor redevelopment project in 1999, which addressed developing parcels of land underneath the Buffalo Skyway. In 2004, a new plan was created, centered around the creation of historically-aligned canals and mixed-use development. Several delays and controversies surrounding the planning, redevelopment and construction of the district drew reaction from the public, notably the inclusion of a flagship Bass Pro Shops store in 2007 that was later scrapped. The Memorial Auditorium was demolished by July 2009, and the land it occupied was subdivided into the historically aligned parcels from the 19th century, now known as the North and South Aud Block. Since 2010, the district has seen an uptick in construction projects and touring concerts and events. Projects completed or underway in the vicinity include LECOM Harborcenter adjacent to Main Street and Explore & More Children's Museum on the South Aud Block.

Theater is a former Buffalo Metro Rail station that served the entertainment and theater districts of downtown Buffalo, New York located in the 600 block of Main Street between Chippewa and Tupper Streets at the north end of the Free Fare Zone, where customers traveling north are required to have proof-of-payment.

The Rae Flats and The Raleigh, also known as The Phoenix; The Hotel Raleigh; The Tudor Arms; The Phoenix Apartments, are two historic apartment buildings located in the Allentown neighborhood of Buffalo, Erie County, New York. The Rae was built about 1892, and is a three-story, polychromatic brick building over a raised basement with Norman inspired detailing. The Rae houses a total of seven apartments. The Raleigh was built about 1896 as a Jewish clubhouse and converted to apartments in 1901. It is a four-story, Romanesque Revival style brick building that houses 28 apartments.It was listed on the National Register of Historic Places in 2016.

School 13, also known as Boys Vocational High School and Buffalo Alternative High School, is a historic school building located at Buffalo in Erie County, New York. It was built about 1915, and is a three-story, steel framed building sheathed in brick and terra cotta with Beaux-Arts style design elements. The "T"-shaped building housed administrative offices, classrooms, a gymnasium, swimming pool, and two-story auditorium. The building housed a school until 2003.It was listed on the National Register of Historic Places in 2005.

Shea's Performing Arts Center (originally Shea's Buffalo) is a theater for touring Broadway musicals and special events in Buffalo, New York. Originally called Shea's Buffalo, it was opened in 1926 to show silent movies. It took one year to build the entire theatre. Shea's boasts one of the few theater organs in the US that is still in operation in the theater for which it was designed.

Trinity Episcopal Church is a historic Episcopal church complex located at Buffalo in Erie County, New York. The oldest part of the complex was built in 1869 as the Gothic Revival style Christ Chapel; it was later redesigned in 1913. The main church was constructed in 1884–1886 in the Victorian Gothic style and features stained glass windows designed by John LaFarge and Tiffany studios. The parish house, designed by Cram, Goodhue & Ferguson, was constructed in 1905.It was listed on the National Register Of Historic Places in 2008.