Roswell Park Comprehensive Cancer Center

The Buffalo Niagara Medical Campus (BNMC) is a medical center of health care, life sciences research and medical education institutions, co-located on 120 acres (49 ha) in Buffalo, New York. The BNMC was founded in 2001 by a consortium (including the University at Buffalo School of Medicine and Roswell Park Comprehensive Cancer Center). This project comprises one of the five "Strategic Investment Areas" that make up Buffalo, NY's Queen City Hub Plan, the city's strategic plan for urban redevelopment.

M. Wile and Company Factory Building is a historic garment factory located at Buffalo in Erie County, New York. It is an early and significant example of the "Daylight Factory." The four story building erected in 1924, is constructed of reinforced concrete and features curtain walls of metal sash windows. It was home to M. Wile & Company until 1999; a major manufacturer of men's suits founded by Mayer Wile in Buffalo in 1877. In 1969, the company became a subsidiary of Hartmarx.In 2007, plans were announced for redevelopment of the historic factory building as part of the Buffalo Niagara Medical Campus. The first floor of the building is occupied by the Buffalo Employment and Training Center.It was listed on the National Register of Historic Places in 2000.

Trico Plant No. 1 is a historic windshield wiper factory building located in Buffalo, New York. It is an example of a style of architecture sometimes referred to as the daylight factory, a style for which Buffalo is well known. The building was mostly constructed in the 1920s and 1930s of reinforced concrete and features curtain walls of metal sash windows and brick spandrels, although a portion of the plant incorporates an historic brewery building from the 1890s. It was the original home of Trico Products Corporation, the first manufacturer of windshield wipers, and was an important factory during a period when Trico was the largest employer in the city of Buffalo. The building is also known for once being the office of John R. Oishei (1886–1968), the company's founder and an industrialist who went on to become one of the most important philanthropists in the Buffalo Niagara Region. The Trico business continued to operate at the building until 1998, when, after having transferred most of its manufacturing facilities to Texas and Mexico, the company moved out of the building. In 2003, plans were developed and conditionally approved by the New York State Historic Preservation Office to reuse the building as a mixed residential and commercial structure. That developer subsequently died, and in 2007 the property was purchased by the Buffalo Niagara Medical Campus (BNMC). After sitting dormant for another four years, it was reported that BNMC planned demolition of about 95% of the building beginning on April 15, 2012 (saving only the brewery building). Meanwhile, community groups have called attention to BNMC's refusal to conduct an adaptive reuse study or evaluation process prior to demolition to assess the feasibility of building reuse.Trico Plant No. 1 was listed on the National Register of Historic Places in 2001.As of October 2019, large portions of the southernmost (1890-1937) sections of the building are being demolished; the remaining portions are being renovated into a mixed-use complex including a hotel and loft apartments. The building will essentially be separated into two halves.

John R. Oishei Children's Hospital (OCH), sometimes known as simply Oishei Children's is a women's and children's hospital in Buffalo, New York, that opened on November 10, 2017, and provides pediatric specialties and subspecialties to infants, children, teens, and young adults up to age 21, and maternity services for expectant mothers. It is located at the Buffalo Niagara Medical Campus and has 185 inpatient beds. It is a pediatric facility serving patients in Western New York and parts of Southern Ontario. The hospital is one of the only freestanding children's hospitals in New York State. OCH is a teaching hospital affiliated with the State University of New York at Buffalo and is affiliated with the Kaleida Health System. The hospital contains an ACS verified level 1 pediatric trauma center, one of the few in the region. OCH also has a rooftop helipad to transport critically ill patients to and from the hospital.The hospital is named after the John R. Oishei Foundation, which donated $10 million for the development of the hospital.

Kaleida Health, founded in 1998, is a not-for-profit healthcare network that manages five hospitals in the Buffalo-Niagara Falls metropolitan area. Prior to the merger of member hospitals into the network, it was known as the Millard Fillmore Health System.

The Gates Vascular Institute and the University at Buffalo‘s Clinical and Translational Research Center is a 10 story building at 875 Ellicott St, Buffalo, New York. The Institute is next to Buffalo General Medical Center and opened on May 24, 2012. The building was designed by Mehrdad Yazdani of CannonDesign and offers services for stroke care, cardiac surgery, and vascular services. Project costs were approximately $290,000,000.

Saint Louis Roman Catholic Church is the oldest Catholic parish in Buffalo, New York. It was the first Catholic church built in Buffalo, and holds the title of "Mother Church of the Roman Catholic Diocese of Buffalo".

The Anchor Bar is a bar and restaurant in Buffalo, New York, located north of Downtown Buffalo at the intersection of Main and North Streets. The restaurant was initially established in 1935. The bar is most famous for allegedly being the birthplace of spicy chicken wings known outside the Buffalo area as Buffalo wings.

Buffalo Trunk Manufacturing Company Building is a historic factory and warehouse building located at Buffalo in Erie County, New York. It is a five-story, eight bay, red brick, "L" shaped, flat roofed industrial building constructed in two phases, 1901–1902 and 1906–1907. It is an example of "slow burn" masonry and wood factory construction.It was listed on the National Register of Historic Places in 2010.

The Twentieth Century Club is a women's social club founded in the late 19th century in Buffalo, New York. It is located at 595 Delaware Avenue, in the Delaware District neighborhood. It was the first club run by women, for women, in the United States.The club developed out of the Graduates Association of the Buffalo Seminary, spearheaded by Charlotte Mulligan, a teacher, writer, and musician from a well-to-do family. She envisioned a club rich in tradition, education, and culture. The Twentieth Century Club became noted for the many lavish social events held there, but education was, and still is, the primary focus of activity. Starting with an 1894 lecture on Abraham Lincoln, and continuing through the present, the Club has a long tradition of presenting prominent speakers and programs by recognized experts on a wide variety of subjects. From the 19th century, when women couldn't vote and had limited opportunity, to today in the 21st century when possibilities seem limitless, the Twentieth Century Club has truly spanned its namesake century and connected those prior and succeeding. Its history parallels and chronicles not only the history of events in Buffalo, but also that of the enormous societal changes which have occurred in its lifespan.In 1894, the club purchased the present property and hired the firm of Green & Wicks to design a clubhouse to add to the front of an existing Baptist church. The clubhouse is a three-story building in the Italian renaissance style. The building is 78 feet wide and 96 feet deep. The first story is of Indiana limestone and the rest of the structure of pressed brick, of a warm red tone, with a cornice of terra cotta. The Ionic order pillars across the front of the second story are of blue marble. The original church structure at the rear of the lot was demolished in 1904 and a gymnasium, pool, showers, and a hot room were added. Additional land and a formal garden were added to the rear of the property in 1933.In 2011 the building was listed on the National Register of Historic Places.

The Shea's 710 Theatre (originally known as the Studio Arena Theatre) is a theatre in Buffalo, New York. It was founded in the 1920s and briefly closed in 2008 citing $3 million in debt and laying off its staff. It was reopened as the 710 Main Theatre in 2012 and is managed by Shea's Performing Arts Center.

Theodore Roosevelt Inaugural National Historic Site preserves the Ansley Wilcox House, at 641 Delaware Avenue in Buffalo, New York. Here, after the assassination of William McKinley, Theodore Roosevelt took the oath of office as President of the United States on September 14, 1901. A New York historical marker outside the house indicates that it was the site of Theodore Roosevelt's Inauguration.