Twinehurst American Optical Company Neighborhood

The George Sumner House is a historic house at 32 Paige Hill Road in Southbridge, Massachusetts. The 2+1⁄2-story late Federal wood-frame house was built sometime before 1830, probably for Major George Sumner (who is recorded as its owner in 1855). Sumner was a leader in the early development of the textile industry in Southbridge, being the first in the area to offer as a service the complete cycle of woolen textile processing, although some work was still initially done in homes, not in a factory setting. The house is notable for the fanlight window on the gable end, which is a late 19th-century addition.The house was listed on the National Register of Historic Places in 1989.

Southbridge station is a former train station in Southbridge, Massachusetts. Built in 1910 by the New York, New Haven and Hartford Railroad (NYNH&H), it is a rare local example of Spanish Mediterranean architecture, and is the only surviving railroad building in the town. The building was listed on the National Register of Historic Places in 1989 as New York, New Haven & Hartford Passenger Depot. It presently serves as the town's registry for motor vehicles.

The Central Mills Historic District encompasses a historic mill complex on the Quinebaug River in central Southbridge, Massachusetts. Located at the corner of Foster and North Streets, the site consists of three brick buildings, the oldest of which has portions dating to 1837. Despite being extensively rebuilt in the early 20th century, the complex has an appearance that is more typical of 19th century mills.The Central Manufacturing Company was established in 1837, and was one of Southbridge's major employers well into the 20th century. The company built its premises on the site of Southbridge's earliest grist- and sawmills, and the town grew around the facility. By late in the 19th century most New England textile mills were in decline, due to increased competition in the South. However, Central Manufacturing embarked on a major renovation of its plant in 1908. It knocked a significant portion of the 1837 plant, and built the present two story brick structure, with the surviving 1837 section attached to its rear. The building is in the Romanesque Revival style, with rounded arch windows and a small tower.In addition to the main factory building, there are two other buildings in the complex. One is a small single story office building, also built in 1908 and with Romanesque Revival styling. This building is on the same parcel as the main building. The third building is a more utilitarian brick warehouse, built 1915, which is located across North Street (but also fronting on Foster) from the main building.The district was listed on the National Register of Historic Places in 1989.

The Dunbar-Vinton House is a historic house at Hook and Hamilton Streets in Southbridge, Massachusetts, USA. Probably built in the early 19th century, it is locally unusual for its brick construction at that time, and may have been built as a district schoolhouse. It was listed on the National Register of Historic Places in 1989.

The Comins-Wall House is a historic house located at 42 Hamilton Street in Southbridge, Massachusetts. Built about 1850, it is a distinctive local example of a Greek Revival cottage with later Victorian embellishments. It was listed on the National Register of Historic Places on June 22, 1989.

The Windsor Court Historic District is a residential historic district in Southbridge, Massachusetts, United States. It is a collection of five three-family residences located on Windsor Court and adjacent North Street that were built by the American Optical Company between 1915 and 1917 to provide worker housing. The district was listed on the National Register of Historic Places in 1989.

The Building at 38–42 Worcester Street is a historic six-unit triple decker in Southbridge, Massachusetts. Built sometime between 1878 and 1898, it has features influenced by the area's then-growing French Canadian immigrant population, including its outside porches. The building was listed on the National Register of Historic Places in 1989.

St. George's Greek Orthodox Church is a historic Greek Orthodox Church building at 55 North Street in Southbridge, Massachusetts. Built in 1932, it is the oldest Orthodox church in the city, and is a locally rare example of Byzantine and Greek architecture. The church was listed on the National Register of Historic Places in 1989.

The Theodore Harrington House is a historic house at 77 Hamilton Street in Southbridge, Massachusetts.

The George H. Hartwell House is a historic house at 105 Hamilton Street in Southbridge, Massachusetts. It is a rare example of a modest vernacular Italianate house in Southbridge, and one of the only ones built of brick. It was built in the 1850s, not long after that stretch of Hamilton Street was laid out, for Dr. George Hartwell, nephew of Dr. Samuel Hartwell. The Hartwells controlled the Hartwell Block on Main Street, and George Hartwell ran a pharmacy, which continued in business into the 1970s. While the house has significant Italianate features such as bracketed eaves and paired windows, it lacks the flat roof line that is characteristic of other local Italianate houses, and is less massive than the more imposing James Gleason House and Chamberlain-Bordeau House.The house was listed on the National Register of Historic Places in 1989.

The Centre Village Historic District encompasses the historic central business district of Southbridge, Massachusetts. The district includes properties on Main Street, roughly between Elm and Goddard Streets. The central area represents a fairly well preserved Late Victorian commercial center. It was added to the National Register of Historic Places in 1979.

The E. Merritt Cole House is a historic house at 386 Main Street in Southbridge, Massachusetts. Built in the early 19th century and restyled sometime between 1855 and 1878, it is a distinctive local example of Gothic Revival architecture. The house was listed on the National Register of Historic Places in 1989.