Main Street–Frye Street Historic District

The Senator William P. Frye House is a historic house on 453-461 Main Street in Lewiston, Maine. Built in 1874, it is a fine example of Second Empire architecture in the city, designed by local architects Fassett & Stevens for William P. Frye, a mayor of Lewiston and a United States senator. The house was listed on the National Register of Historic Places in 1976.

Mount David (also known as Mount Davis, Davis Mountain, and David's Mountain) is a rocky summit in Lewiston, Maine, on the campus of Bates College in back of Rand Hall. It is one of the highest points in Lewiston at 381 feet and offers views of the White Mountains including Mount Washington on a clear day.

The Holland–Drew House is a historic house at 377 Main Street in Lewiston, Maine. Built in 1854, it is a high-quality local example of Italianate architecture executed in brick. It is also notable for some of its owners, who were prominent in the civic and business affairs of the city. The house was listed on the National Register of Historic Places in 1978.

The James C. Lord House is a historic house in Lewiston, Maine. Built in 1885 for a prominent local businessman, it is a high quality blend of late 19th-century architectural styles. It was listed on the National Register of Historic Places in 1978.

WRBC is the college radio station of Bates College, located in Lewiston, Maine and at 91.5 MHz on the FM dial. The WRBC studio is located in the basement of 31 Frye Street across from the student coffee house, The Ronj. The WRBC board of directors publish an online music blog called The Monkey.WRBC is currently ranked by The Princeton Review as the 12th best college radio station in the United States and Canada, making it the top college radio in the New England Small College Athletic Conference. WRBC was also the Maine headquarters for College Radio Day in October 2012.

The Captain Holland House is an historic house in Lewiston, Maine. Built in 1872, this three-story brick building is a fine local example of the Second Empire style. It was built by Daniel Holland, one of the city's leading industrialists. The house was listed on the National Register of Historic Places in 1985.

The Bradford Peck House is a historic house at 506 Main Street in Lewiston, Maine. Built in 1893, it is an unusual example of a rambling and asymmetrical Colonial Revival house. It was designed by local architect George M. Coombs and built for Bradford Peck, owner of Peck's Department Store, one of the largest such stores in New England. The building was added to the National Register of Historic Places in 2009. It now houses professional offices.

The Isaacson House is a historic house at 2 Benson Street in Lewiston, Maine. Built in 1959 for Philip M. Isaacson, a local lawyer, it is a distinctive regional example of modest Mid-Century Modern residential architecture, that drew nationwide notice in architectural circles after its construction. It was listed on the National Register of Historic Places in 2011.

The John D. Clifford House is a historic house in Lewiston, Maine. Built in 1926, it is one of a modest number of examples statewide of Mediterranean Revival, and the only one known to have been built as a year-round residence. The building features an eclectic mix of styles, and has a builtin garage, also a rarity for the period. The house was listed on the National Register of Historic Places in 1987.

Riverside Cemetery is a cemetery in Lewiston, Maine. The 40-acre (16 ha) cemetery is located on the bank of the Androscoggin River which flows through Lewiston. It is owned by the Riverside Cemetery Association.An historic cemetery still in use today, Riverside Cemetery was incorporated in 1855 after a group of city leaders purchased land from Bates College, then known as the Maine State Seminary. Part of the property included the Greenwood Cemetery which had been in use since the 1830s as well as farm land owned by the Whipple Family.Among the original founders of the cemetery were William P. Frye, Alonzo Garcelon, Amos Nevins, Daniel Hamilton, Samuel Bearce, Armis Nash, Samuel Haley, and Donald Holland. Many historically important men and women are buried at Riverside, including 24 Mayors, 2 Governors, 1 Civil War General, 1 US Senator and more than 1200 veterans of wars dating back to the Revolutionary War. Various walking tours are featured highlighting the lives of those who call Riverside their final resting place.The earliest recorded burial was in 1834, Dean Frye, Esquire. The brick residence was built in the 1850s. Designed as a rural cemetery similar to Mount Auburn Cemetery in Cambridge, MA, the serpentine roads of the oldest part of the Riverside's grounds curve among magnificent old oaks and maples overlooking the Androscoggin River. Later development of the cemetery focused on the lawn style of cemetery design which allowed for more symmetrical organization of the lots. Tall obelisks, mausoleums and statuary dot the landscape. Birdwatchers are particularly fond of the many species found there and the City of Lewiston's Androscoggin Riverside Trail which skirts the cemetery's perimeter is popular with walkers and runners.

The Jordan School is a historic school building at 35 Wood Street in Lewiston, Maine. Built in 1902, it is an important local example of Italian Renaissance architecture, designed by the architect William R. Miller. It served as the city's first purpose-built high school, and has been converted to residential use. It was listed on the National Register of Historic Places in 1984.

The Central Maine Medical Center is a hospital located at 300 Main Street in the city of Lewiston, Maine. It serves most of Androscoggin County, including Lewiston and Auburn, Maine and various small and medium-sized communities. It is designated as a trauma center. The hospital was established in the 1860s and officially incorporated in 1888 by Dr. Edward H. Hill, an alumnus of nearby Bates College and also Harvard Medical School. The hospital is currently a teaching affiliate of Boston University School of Medicine and University of New England College of Osteopathic Medicine.