125th Street station (IRT Ninth Avenue Line)

On December 8, 1995, eight people, including the assailant, were killed when a gunman seized hostages at Freddy's Fashion Mart in Harlem, New York City and set the building on fire.

Braddock Hotel was a hotel at the corner of 126th Street and 8th Avenue in New York City, near the Apollo Theater. The hotel bar was popular with black jazz musicians, and Dizzy Gillespie, Billy Eckstine, Billie Holiday, Ella Fitzgerald and Dinah Washington performed here. Before he joined the Nation of Islam, Malcolm X (then known as Malcolm Little) often spent time at the hotel's bar.There was also a Braddock Hotel near the Southland ballroom in Warrenton Street, Boston.

The Apollo Theater is a music hall at 253 West 125th Street between Adam Clayton Powell Jr. Boulevard (Seventh Avenue) and Frederick Douglass Boulevard (Eighth Avenue) in the Harlem neighborhood of Upper Manhattan in New York City. It is a noted venue for African-American performers, and is the home of Showtime at the Apollo, a nationally syndicated television variety show which showcased new talent, from 1987 to 2008, encompassing 1,093 episodes; the show was rebooted in 2018. The theater, which has a capacity of 1,506, opened in 1913 as Hurtig & Seamon's Music Hall. It was designed by George Keister in the neo-Classical style. Alterations were made that year for showing movies, and it was renamed the Apollo Theater. (It was often referred to as the "125th Street Apollo" to distinguish it from the legitimate Apollo on 42nd Street). In 1924, the Minsky brothers leased the theater for burlesque shows. In 1934, it became a venue for black performers and was opened to black patrons for the first time. In 1983, both the interior and exterior of the building were designated as New York City Landmarks, and the building was added to the National Register of Historic Places. It is estimated that 1.3 million people visit the Apollo every year.

125th Street, co-named Martin Luther King Jr. Boulevard, is a two-way street that runs east–west in the New York City borough of Manhattan, from First Avenue on the east to Marginal Street, a service road for the Henry Hudson Parkway along the Hudson River in the west. It is often considered to be the "Main Street" of Harlem. Notable buildings along 125th Street include the Apollo Theater, the Adam Clayton Powell Jr. State Office Building, the Hotel Theresa, the Studio Museum in Harlem, the Mount Morris Bank Building, Harlem Commonwealth Council, the Harlem Children's Zone, the Church of St. Joseph of the Holy Family, and the former West End Theatre, now home to the La Gree Baptist Church.

The 125th Street station is an express station on the IND Eighth Avenue Line of the New York City Subway. Located at the intersection of 125th Street and St. Nicholas Avenue in the Harlem neighborhood of Manhattan, it is served by the A and D trains at all times, by the C train at all times except late nights, and by the B train on weekdays. Nearby landmarks and points of interest include the Apollo Theater and the Touro College of Osteopathic Medicine.

The Victoria Theater is a theater located on 125th Street in the Harlem neighborhood of the borough of Manhattan in New York City. It was designed in 1917 by Thomas W. Lamb, a notable and prolific theater architect of the era, for the Loew's Corporation.The Loew's Victoria Theater, as it was known until 1977, opened as a 2,394-seat, luxury Vaudeville and motion picture theater. Typical of movie palaces of its era, it contained a stage and backstage dressing rooms and provisions for live music, including an organ. It cost $250,000 to build and was hailed “as one of the largest and most beautiful theaters in greater N.Y.” by a contemporary publication. When the Victoria was built, it joined many other Harlem theaters including the Proctor, Hammerstein Opera House, the Alhambra as well as the nearby Apollo, then the Hurtig & Seamon's New (Burlesque) Theater.In 1977, the Harlem Community Development Corporation acquired the building.The Victoria has experienced numerous changes since its opening, the most radical being its conversion to a multi-screen movie theater; in 1987, five movie theaters were created from the large auditorium, mezzanine and stage areas. The theater closed as a cinema in 1989, though a 400-seat venue was left intact in the orchestra, at which the original Harlem company of Godspell, which drew major newspaper and television network broadcast coverage, ran for approximately a year in the 1996/97 season. In 2005 several proposals for redevelopment were made. Only two proposals call for reusing the theater's interior, which has angered some community leaders, according to the New York Times.The new Victoria Theater project, developed by the Lam Group and Exact Capital, designed by architect Ariel Aufgang and interiors by AJC Design, began construction in April 2017 and was scheduled to open in the spring of 2019. The completed 400,000-square-foot structure will have 191 mixed-income rental apartments; a 210-room Marriott Renaissance hotel; about 25,000 square feet of retail; and another 25,000 square feet of cultural and arts space. This project has suffered numerous delays and was forced to seek refinancing. After a very long process it appears that refinancing was secured in the Spring of 2022. As of September 2022, some portions of the building are open, but the hotel and theater are not operational.

The Touro College of Osteopathic Medicine (TouroCOM) is a private medical school with a main campus in the neighborhood of Central Harlem in New York City and an additional campus in Middletown, New York. It is a division of Touro College and University System.The college's inaugural class graduated in 2011. It was the first medical school to open in New York State in nearly 30 years and is the first osteopathic medical school with a special emphasis on training minority doctors. TouroCOM currently has a student body of about 1080 students.TouroCOM has a stated goal of particularly identifying and recruiting students willing to make a commitment to practice in underserved communities such as Harlem and Middletown. The neighborhood has been designated by the federal government as underserved by medical professionals. Community service events such as free health counseling, screenings, and flu shots are offered to local residents by students and faculty several times a year.

P.S. 157 is a historic school building located at 327 St. Nicholas Avenue between West 126th and West 127th Streets in the Harlem neighborhood of Manhattan, New York City. It was built from 1896 to 1899 and was designed by C. B. J. Snyder in the Renaissance Revival style. It ceased being a school in 1975, and was converted to rental apartments in 1993.

Harlem Opera House was a US opera house located at 211 West 125th Street, in the Harlem neighborhood of Manhattan in New York City. Designed by architect John B. McElfatrick, it was built in 1889 by Oscar Hammerstein; it was his first theater in the city.

The Hotel Theresa is located at 2082-96 Adam Clayton Powell Jr. Boulevard between West 124th and 125th Streets in the Harlem neighborhood of Manhattan, New York City. In the mid-20th century, it was a vibrant center of African American life in the area and the city. The 13-story hotel was built in 1912–13 by German-born stockbroker Gustavus Sidenberg (1843–1915), whose wife the hotel is named after, and was designed by the firm of George & Edward Blum, who specialized in designing apartment buildings. The hotel, which was known in its heyday as "the Waldorf of Harlem", exemplifies the Blums' inventive use of terracotta for ornamentation, and has been called "one of the most visually striking structures in northern Manhattan".The building, now an office building known as Theresa Towers, was designated a New York City landmark in 1993 and was added to the National Register of Historic Places in 2005.

Two theatres in Harlem, New York City, have been named West End Theatre. The first, of 1899, was abandoned after the foundation was built. It was on the northeast corner of 124th Street and Seventh Avenue, which is today known as Adam Clayton Powell Jr. Boulevard.The second is at 362 West 125th Street, on the south side of the street, midway between Morningside Avenue and St. Nicholas Avenue (backing onto Hancock Place). Built by Meyer R. Bimberg and designed by Neville & Bragge in Spanish Baroque style, it opened November 3, 1902 and was sold to Weber & Fields on February 9, 1903.Bimberg, who came to be known as Bim the Button Man, made his fortune selling campaign buttons. He built five theatres in New York City including what is now the Belasco Theatre. The West End Theatre was acquired in 1975 by La Gree Baptist Church. It was sold to a real estate developer in July 2016 and plans for a new mixed-use (commercial and residential) building have been announced for the site.

Sydenham Hospital was a healthcare facility in Harlem, Manhattan, New York, which operated between 1892 and 1980. It was located at 124 Street and Manhattan Avenue.