18th Street station (IRT Third Avenue Line)

Scheffel Hall at 190 Third Avenue in the Gramercy Park neighborhood of Manhattan, New York City, was built in 1894–1895, and designed by Henry Adams Weber and Hubert Drosser, at a time when the area south of it was known as Kleindeutschland ("Little Germany") due to the large number of German immigrants who lived nearby. The building, which served as a beer hall and restaurant, was modeled after an early 17th-century building in Heidelberg Castle, the "Friedrichsbau", and was named after Joseph Viktor von Scheffel, a German poet and novelist. It later became known as Allaire's, a name still inscribed on the building. The building's style has been described as "German-American eclectic Renaissance Revival".Later, in the late 1920s, the building was used by the German-American Athletic Club. By 1939 it became the German-American Rathskeller, and then Joe King's Rathskeller. O. Henry used Scheffel Hall as the setting for "The Halberdier of the Little Rheinschloss" and wrote some of his stories there. Beginning in the 1970s, it was the home of Fat Tuesday's, a well-known jazz club, and the restaurant Tuesday's, which lasted until the early 21st century. It is currently a yoga and pilates studio. Update: as of late August 2020 the building is for rent. Sal Anthony, who had his movement studio here, has died. This is a glorious example of 19th century architecture. Scheffel Hall was designated a New York City landmark in 1997.

The Stuyvesant Apartments, Stuyvesant Flats, Rutherfurd Stuyvesant Flats or simply The Stuyvesant, was an apartment building located at 142 East 18th Street between Irving Place and Third Avenue in the Gramercy Park neighborhood of Manhattan, New York City. It is considered to be the first apartment building in the city intended for the middle class, who previously were not used to living in apartments, which were initially called "French flats" at the time.Before the Stuyvesant, almost all of the housing in New York City consisted of either tenements or townhouses. The Stuyvesant helped to bridge this gap, satisfying the need for higher density but upscale housing. Rents ranged from $1,000 to $1,800 per year, the rough equivalents in 2015 of approximately $8,000 to $14,000 per year.The Stuyvesant was successful, leading the way for other such buildings to be constructed. In their book New York 1880, Robert A. M. Stern and his co-authors wrote that the Stuyvesant was the "foundation stone" of the movement of the middle-class into apartments.

The St. George or The St. George Residence, now functioning under the name of Hotel 17 is a historic building located at 223–225 East 17th Street, on Stuyvesant Square in Manhattan, New York City. It was designated as part of the Stuyvesant Square Historic District, a New York City landmark district, in 1975.

On August 19, 1989, a large steam explosion in front of a residential building generated a large asbestos-containing steam cloud in the Gramercy Park neighborhood of Manhattan, New York City. Two people – a Con Ed worker and a 3rd floor resident – died instantly and 24 were injured. A third person, another Con Ed worker, died the following day. Two hundred residents were displaced for months while cleanup crews worked to remove asbestos-containing mud from building facades. All apartments were remediated by asbestos workers and tested for airborne asbestos. Workers from Con Ed, the major utility company in the area, were repairing a high pressure steam pipe in front of the building when a 30-inch (76 cm) connecting sleeve burst, releasing hot steam and debris upwards. Laboratory testing afterwards determined that the insulating material contained asbestos, which subsequently led to a large-scale evacuation and cleanup. The release from the explosion, in front of 32 Gramercy Park at the corner of 20th Street and Third Avenue, continued for several hours with debris reaching 18 stories. The pipe was covered with asbestos magnesia block insulation which was pulverized and dispersed with the rising steam cloud. Con Ed initially failed to report that the debris contained asbestos, but after 4 days announced that the 200 pounds of insulation did contain the cancer-causing material. Five years later, when indicted on the same issue, the company pleaded guilty to conspiracy and environmental law violations in Federal District Court in Manhattan for withholding that information. The final remediation and cleanup cost totaled approximately $90 million, making this one of the most expensive asbestos cleanup projects in history.

Friends Seminary is an independent K-12 school in Manhattan within the landmarked district in the East Village. The oldest continuously coeducational school in New York City, Friends Seminary serves 780 students in Kindergarten through Grade 12. The school's mission is to prepare students "not only for the world that is, but to help them bring about a world that ought to be." It is guided by a service mission statement and a diversity mission statement. Friends is a member of New York's Independent School Diversity Network. Robert "Bo" Lauder is principal, the school's 35th. Lauder came to Friends in the fall of 2002 after serving as Upper School Head at Sidwell Friends School in Washington, D.C.

St. George's Episcopal Church is a historic church located at 209 East 16th Street at Rutherford Place, on Stuyvesant Square in Manhattan, New York City. Called "one of the first and most significant examples of Early Romanesque Revival church architecture in America", the church exterior was designed by Charles Otto Blesch and the interior by Leopold Eidlitz. It is one of the two sanctuaries of the Calvary-St. George's Parish.

Cabrini Medical Center of New York City was created in 1973 by a merger of two Manhattan hospitals. It closed in 2008 due to financial difficulties cited by the Berger Commission, followed by a bankruptcy filing.In January 2010, the five buildings formerly housing the medical center were purchased by Memorial Sloan-Kettering Cancer Center for $83.1 million, with plans to open an outpatient cancer facility; but in 2013 the buildings were sold to a developer to be converted into residences.

Pete's Tavern, located at 129 East 18th Street on the corner of Irving Place in the Gramercy Park neighborhood of Manhattan, New York City, is a pub food restaurant and one of several drinking establishments each claiming to be the oldest continuously operated tavern in the city.

Pure Food and Wine was a raw food and vegan restaurant co-founded by Sarma Melngailis and chef Matthew Kenney. The restaurant opened in June 2004 at 54 Irving Place in Manhattan. It closed in 2016. It is the subject of the documentary Bad Vegan: Fame. Fraud. Fugitives.

Casa Mono is a restaurant in New York City. The restaurant serves Spanish cuisine and has received a Michelin star.

19 Gramercy Park South, also known as 86 Irving Place or the Stuyvesant Fish House, is a four-story row house located at the corner of Gramercy Park South (East 20th Street) and Irving Place in the Gramercy Park neighborhood of Manhattan, New York City.

The Society for the Lying-In Hospital was an American maternity hospital situated at 305 Second Avenue between East 17th and 18th Streets in the Stuyvesant Square neighborhood of Manhattan, New York City. Now known as Rutherford Place, the building was added to the National Register of Historic Places in 1983. Lying-in is an archaic term for childbirth (referring to the month-long bed rest prescribed for postpartum confinement). It was built in 1902 and designed by architect R. H. Robertson in the Renaissance Revival style, with a Palladian crown at the top. Swaddled babies decorate the windows of the 5th floor and the spandrels of the building, which was converted to offices and apartments in 1985 by Beyer Blinder Belle.As the years passed, John Pierpont Morgan, Jr. was concerned about the long-term stability of the hospital his father had so generously provided for. He recruited John D. Rockefeller, Jr.; George F. Baker, Sr.; and George F. Baker, Jr. to join forces in establishing an association with New York Hospital. Upon the subsequent opening of the New York Hospital-Cornell Medical Center in 1932, the Lying-In Hospital moved out of the Second Avenue building. It became the more modern-sounding Obstetrics and Gynecology Department of New York Hospital, which is still part of NewYork–Presbyterian Hospital. This hospital was "said to account for 60 percent of all births in Manhattan." Some of their staff did medical research.