William H. Wells House

The East Jefferson Avenue Residential District in Detroit, Michigan, includes the Thematic Resource (TR) in the multiple property submission to the National Register of Historic Places which was approved on October 9, 1985. The structures are single-family and multiple-unit residential buildings with construction dates spanning nearly a century, from 1835 to 1931. The area is located on the lower east side of the city.

The John N. Bagley House, also known as Bagley Mansion, was built as a private residence in 1889. The mansion is located at 2921 East Jefferson Avenue in Detroit, Michigan. It was listed on the National Register of Historic Places in 1985. As of 2022, the house is used as a commercial office building, maintaining its historic features and character.

The Battle of Bloody Run was fought during Pontiac's War on July 31, 1763, on what now is the site of Elmwood Cemetery in the Eastside Historic Cemetery District of Detroit, Michigan. In an attempt to break Pontiac's siege of Fort Detroit, about 250 British troops attempted to make a surprise attack on Pontiac's encampment. Pontiac was ready and waiting, possibly alerted by French settlers, and defeated the British at Parent's Creek 2 miles (3.2 km) east of the fort. However, he did not accomplish the destruction of this British force which would have greatly demoralized the British and dissuaded more British efforts to break the Indian siege of Fort Detroit. The creek, or run, was said to have run red with the blood of the 20 dead and 41 wounded British forces and was henceforth known as Bloody Run. The British forces retreated with all their wounded and all but seven of those killed. The attack's commander, Captain James Dalyell, was one of those killed. After learning of Dalyell's death, General Jeffery Amherst offered a £200 bounty to anyone who would kill Pontiac. The famous frontiersman Robert Rogers was one of the British commanders in this battle.

The Players is a clubhouse and theatre located at 3321 East Jefferson Avenue in Detroit, Michigan. It was designated a Michigan State Historic Site in 1985 and listed on the National Register of Historic Places in 1987.

The Joseph Campau House is a private residence located at 2910 East Jefferson Avenue in Detroit, Michigan. It was listed on the National Register of Historic Places in 1985.

Martin Luther King Jr. Senior High School is a public magnet high school located at 3200 East Lafayette Boulevard in Detroit, Michigan; the building is operated by the Detroit Board of Education. King's district encompasses Downtown and Midtown Detroit; it also includes Lafayette Park, the Martin Luther King Apartments and Riverfront Condominiums. The Brewster-Douglass Housing Projects were zoned to MLK prior to their demolition. In addition it includes the three Wayne State University housing complexes that permit families with children (Chatsworth Tower, DeRoy, and University Tower).

Garden Court Condominiums (originally Garden Court Apartments) is a condominium building located at 2900 East Jefferson Avenue in Detroit, Michigan. It was listed on the National Register of Historic Places in 1985.

The Franklin H. Walker House was a private residence located at 2730 East Jefferson Avenue in Detroit, Michigan. It was also known as Doctor's Hospital. The house was listed on the National Register of Historic Places in 1985, but subsequently demolished in 1998. It was at the time the largest remaining house along Jefferson Avenue.

The historic River Place (also known as Stroh River Place) is located in Detroit, Michigan, bounded by Joseph Campau Avenue, Wight Street, McDougall Street, and the Detroit International Riverfront. It was formerly the Parke-Davis and Company Pharmaceutical Plant. The complex was listed on the National Register of Historic Places in 1985.

The Roberts Riverwalk Urban Resort Hotel, formerly the Parke-Davis Research Laboratory also once known as Building 55-Detroit Research, is a luxury hotel on the Detroit International Riverfront in Detroit, Michigan. The former research facility was redeveloped as a boutique luxury hotel in the 1980s. The building was designated a National Historic Landmark in 1976 for its historic significance as an early research laboratory.

The Alexander Chêne House was a private residence located at 2681 East Jefferson Avenue in Detroit, Michigan. It was listed on the National Register of Historic Places in 1985 and designated a Michigan State Historic Site in 1986, but subsequently demolished in April 1991.

Rev. James Robinson (1753–1868) was born on the Eastern Shore of Maryland into bondage on March 21, 1753. His enslaver was Francis De Shields. Robinson served under the General Gilbert du Motier, Marquis de Lafayette and would become a significant African American soldier in the American Revolutionary War.