Sons of the American Revolution

The Louisville Slugger Museum & Factory, is a museum and factory tour attraction located in Louisville, Kentucky's "Museum Row", part of the West Main District of downtown. The museum showcases the story of Louisville Slugger baseball bats in baseball and in American history. The museum also creates temporary exhibits with more of a pop culture focus, including collaborations with the Norman Rockwell Museum, the Charles M. Schulz Museum and Research Center, Coca-Cola, LEGO artists Sean Kenney and Jason Burik, Topps Trading Cards, The Children's Museum of Indianapolis, and Ripley's Believe It or Not!.The building also houses corporate offices for Hillerich & Bradsby (H&B) and its two other divisions, Bionic Gloves and PowerBilt Golf Clubs. Wilson Sporting Goods also maintains much of its Louisville Slugger sales force in the building after purchasing the brand from H&B in 2015. The Hillerich family maintains ownership of the museum and bat factory.

A statue of Baseball Hall of Famer Roberto Clemente was installed at the Louisville Slugger Museum & Factory in Louisville, Kentucky, in 2021.

The Frazier History Museum, previously known as the Frazier Historical Arms Museum and the Frazier International History Museum, is a history museum located on Museum Row in the West Main District of downtown Louisville, Kentucky.An affiliate of the Smithsonian Institution, the Frazier is home to one of the largest collections of toy soldiers and historic miniatures on permanent public display in the world, The Stewart Collection. Subjects of other permanent exhibitions include historic arms, bourbon whiskey, and the Lewis and Clark Expedition.Founded in 2004 as a museum of historical arms and armor, the Frazier has since expanded its focus to cover regional, national, and international history.In 2018, the Frazier became the official starting point of the Kentucky Bourbon Trail.

The Kentucky Science Center, previously known as the Louisville Museum of Natural History & Science and then Louisville Science Center, is Kentucky's largest science museum. Located in Louisville, Kentucky, on "Museum Row" in the West Main District of downtown, the museum operates as a non-profit organization. It was founded in 1871 as a natural history collection. Many students in Kentucky take field trips to the Kentucky Science Center. There are about 550,000 visitors annually. A special hands-on area for children, featuring six educational activity sections, was renovated and renamed as KidZone in 1998. The building is located at 727 West Main Street and is about 150,000 sq ft (14,000 m2). The distinctive cast-iron facade limestone building was originally built in 1878 as a dry goods warehouse. The city purchased the property in 1975, and the museum moved to the premises in 1977, subsequently winning several design awards for its preservation of the building. A four-story digital theater was added in 1988 and renovated in early 2014. The pendulum has been a fixture of the building for decades. On January 11, 2007, it was announced that the Kentucky Science Center would acquire the Alexander Building, which was built in 1880, adjacent to the original building. In 2009, the center opened a Science Education Wing on the building's first floor. The wing includes four science-workshop labs equipped for "hands-on participation". The five-story Alexander Building is nearly 37,000 square feet (3,400 m2).

Kentucky Academy of Science (KAS) is the Kentucky affiliate of the American Association for the Advancement of Science and the National Association of Academies of Science. The organization "fosters scientific discovery and understanding in Kentucky". It is a statewide scientific society serving scientists and science advocates. Projects include various outreach initiatives to advance science literacy in Kentucky and policy advocacy around scientific and educational issues. The KAS has passed resolutions in favor of evolution in 1981, 1983, 1999, and 2005, and have stood up against a series of legislative efforts in Kentucky to undermine science education

KMAC Contemporary Art Museum is an American art museum that "connects people to Art and Creative Practice". The museum is a 501c3 organization located in the West Main District of downtown Louisville, Kentucky

The West Main District is one of the five districts of downtown Louisville, Kentucky. The district, or a portion of it, is listed in the National Register of Historic Places as West Main Street Historic District, due to its containment of some of the oldest structures in the city. The buildings of this district boast the largest collection of cast iron façades of anywhere outside New York's SoHo district. The district also features "Museum Row", a collection of several notable museums located within just a few blocks of each other. The district, named for its main corridor of West Main Street, includes the 800-600 blocks of Main and the southern side of the 500 block.

The Snead Building located at 815 W. Market St. is a multi-use facility housing two working glass studios (two glass galleries): a Walk-In Workshop and tours by appointment.

Downtown Louisville is the largest central business district in the Commonwealth of Kentucky and the urban hub of the Louisville, Kentucky Metropolitan Area. Its boundaries are the Ohio River to the north, Hancock Street to the east, York and Jacob Streets to the south, and 9th Street to the west. As of 2015, the population of downtown Louisville was 4,700, although this does not include directly surrounding areas such as Old Louisville, Butchertown, NuLu, and Phoenix Hill. The five main areas of the Central Business District consist of: West Main District (west of 2nd St., north of Market St., east of 9th St., and south of the Ohio River) East Main District (east of 2nd St., north of Market St., west of Hancock St., and south of the Ohio River; contains the Whiskey Row Historic District) Medical Center (east of 2nd St., south of Market St., west of Hancock St., and north of Jacob St.) Fourth St. District (south of Market St., west of 2nd St., north of York St., and east of 5th St.) Civic Center (south of Market St., west of 5th St., north of York St., and east of 9th St.)The tallest buildings in Kentucky are located in downtown Louisville and include 400 West Market designed by John Burgee, PNC Tower designed by Harrison & Abramovitz, PNC Plaza designed by Welton Becket, and the Humana Building designed by Michael Graves. Of the 16 buildings in Kentucky over 300 feet (91 m), 12 are in downtown Louisville. In addition, it is the center of local and regional government. A glassed-in skywalk called the Louie Link stretches six city blocks and links together the Kentucky International Convention Center (KICC), Fourth Street Live!, three hotels (Galt House Hotel & Suites, Marriott and Hyatt Regency), and 2,300 hotel rooms. In 2010 it was extended from the Galt House to the new $16 million Skywalk Garage, an eight-level, 860-space parking facility on Third Street, and a second skywalk connects from the garage across Third Street to the new KFC Yum! Center.

Louisville Museum Plaza was a 62-story skyscraper that was planned for Louisville, Kentucky, United States. By August 1, 2011, despite the expenditure of public funds on its behalf, its developers had officially announced that they were abandoning plans to build it. The 703-foot (214 m) tall skyscraper was projected to cost $490 million and contain a 1-acre (0.40 ha) public plaza and park, condominiums, lofts, a hotel, retail shops and a museum. If built, it would have replaced the AEGON Center as the tallest building in Kentucky. The avant-garde design of the skyscraper was chosen by New York City REX architect Joshua Prince-Ramus. A groundbreaking ceremony was held on October 25, 2007, and construction at that time was expected to be complete by 2010. Delays disrupted the project. Prior to announcing that the project had been abandoned, Craig Greenberg, one of the projects four developers, had stated that he was "hopeful that construction will start this year [2010]" and that he also expected the project to be completed by late 2012.The location of Museum Plaza would have been between River Road, Main Street, 7th Street and 6th Streets in downtown within the West Main district, adjacent to the Muhammad Ali Center.

Fort Nelson, built in 1781 by troops under George Rogers Clark including Captain Richard Chenoweth, was the second on-shore fort on the Ohio River in the area of what is now downtown Louisville, Kentucky. Fort-on-Shore, the downriver and first on-shore fort, had proved to be insufficient barely three years after it was established. In response to continuing attacks from Native Americans and the threat of British attacks during the Revolutionary War, Fort Nelson was constructed between what is currently Main Street and the river, with its main gate near Seventh Street. It was named after Thomas Nelson Jr., then the governor of Virginia. (Kentucky was part of Virginia at the time.) The fort was used as a courthouse and jail until one was built. The fort was garrisoned until the building of Fort Finney across the river at the site of what is today Jeffersonville, Indiana about 1784. In the fort's place today stands Fort Nelson Park, a pocket park housing a granite monument commemorating the fort.

David (inspired by Michelangelo) is a sculpture by Turkish conceptual artist Serkan Özkaya. It is a reproduction of Michelangelo's David made of gold-painted foam, twice the size of the original, and based on a computer model by Stanford University professor Marc Levoy. It was originally created for the 9th International Istanbul Biennial in 2005, and took six people six months to build, but it collapsed during installation.The statue was restored and two copies were cast at a workshop in the Turkish city of Eskişehir. One of them will be displayed at a park in Eskişehir. The other was acquired by the 21c Museum Hotel in Louisville, Kentucky, and was transported, lying on its side on a truck trailer, into New York City in March 2011 for a presentation at the Storefront for Art and Architecture before continuing on to its permanent location in Louisville.The sculpture is a subject of a 2010 film by Danila Cahen, Friendly Enemies, and of a 2011 book, Rise and Fall and Rise of David (inspired by Michelangelo).