Francis Deane Cottage

The Uxbridge Common District is located in downtown Uxbridge, Massachusetts. It is listed on the National Register of Historic Places. Historic buildings in this district include the Uxbridge Academy, Uxbridge Free Public Library, the Deborah A. Wheelock House, a blacksmith shop, the First Congregational Church, and the Unitarian Church.

The William Hayward House is an historic house located at 77 North Main Street, in Uxbridge, Massachusetts. This 2+1⁄2 story wood-frame house was built in 1876 for William Hayward, a banker and business partner of the locally prominent mill owner Moses Taft. The house is an excellent local example of Italianate styling, although its elaborate porch is a later c. 1900 modification. The property also has a period carriage house in good condition and has been occupied by the George and Louise Kurzon family for 100 years.On October 7, 1983, it was added to the National Register of Historic Places.

The Benjamin Adams House is a historic house located at 85 North Main Street, in Uxbridge, Massachusetts. Probably built before 1792, it is a good quality example of Federal period architecture, built for a prominent local lawyer and businessman. On October 7, 1983, it was listed on the National Register of Historic Places.

The Uxbridge Free Public Library is the public library in Uxbridge, Massachusetts. It opened in 1875. The first library in the town of Uxbridge was the Uxbridge Social and Instructive Library (1775–1812), managed by George Southwick at his store in the Quaker City section of South Uxbridge. The sixth was the Uxbridge Agricultural Society (1859–1864). Most of these small libraries were subscription libraries that required dues and assessments. In 1874, the Uxbridge voters elected six trustees to set up a free library. They met on April 18, 1874 to organize the Uxbridge Free Public Library. It opened in the FW Barnes jewellery store on South Main Street on January 20, 1875. After five years, the free library moved into the Town Hall. On June 20, 1894. the library's new home, the Thayer Memorial building, was dedicated . Edward Carrington Thayer, a local business man and banker, had built it and donated it to the town in memory of his parents, Joseph and Chloe Taft Thayer The Thayer Memorial building was designed by Fuller & Delano of Worcester as architects and the building contract to Urgel Jacques of Worcester. Thayer spent $28,000 for the building, $4,000 for the land and $1,500 for furnishings, for a total of $33,500. The Thayer Memorial building still houses the Uxbridge Free Public Library.

Uxbridge is a town in Worcester County, Massachusetts, United States, first colonized in 1662 and incorporated in 1727. It was originally part of the town of Mendon, and named for the Earl of Uxbridge. The town is located 36 mi (58 km) southwest of Boston and 15 mi (24 km) south-southeast of Worcester, at the midpoint of the Blackstone Valley National Historic Park. The historical society notes that Uxbridge is the "Heart of The Blackstone Valley" and is also known as "the Cradle of the Industrial Revolution". Uxbridge was a prominent Textile center in the American Industrial Revolution. Two Quakers served as national leaders in the American anti-slavery movement. Uxbridge "weaves a tapestry of early America".Indigenous Nipmuc people near "Wacentug" or “Waentug” (river bend), deeded land to 17th-century settlers. Uxbridge reportedly granted rights to America's first colonial woman voter, Lydia Taft, and approved Massachusetts first women jurors. The first hospital for mental illness in America was reportedly established here. Deborah Sampson posed as an Uxbridge soldier, and fought in the American Revolution. A 140-year legacy of manufacturing military uniforms and clothing began with 1820 power looms. Uxbridge became famous for woolen cashmeres. "Uxbridge Blue", was the first US Air Force Dress Uniform. BJ's Wholesale Club distribution warehouse is a major employer today. Uxbridge had a population of 14,162 at the 2020 United States Census.

The Farnum Block was an historic commercial building located at 1 South Main Street, in Uxbridge, Massachusetts. It was a three-story brick building with Renaissance Revival styling, and was built sometime between 1895, when a fire destroyed commercial buildings in the area, and 1898. On October 7, 1983, it was added to the National Register of Historic Places. Sometime thereafter it was demolished.

The Taft Brothers Block is an historic commercial building at 2-8 South Main Street, in Uxbridge, Massachusetts. Prominently located in the town center at the corner of Mendon and Main Streets, it is a three-story brick structure, with modest Late Victorian stylistic embellishments. Its first floor has commercial retail storefronts, while the upper-floor windows are set in openings with granite sills and lintels. Brick corbelling marks the cornice below the flat roof. The upper floor is taller than the other floors, and houses a large auditorium space. It was built in 1896 for Robert and Jacob Taft, operators of a grocery, after the previous building on the site was destroyed by fire.On October 7, 1983, it was added to the National Register of Historic Places.

The Judson–Taft House is a historic house located at 46 Pleasant Street, in Uxbridge, Massachusetts. The 2+1⁄2 story wood-frame house was built c. 1845–55, and is one of Uxbridge's most elaborate examples of high style Greek Revival design. The house occupies a site overlooking the center of Uxbridge, and its front yard originally extended all the way to Main Street. Its full two-story portico is supported by Doric columns, and its corner boards are pilastered.On October 7, 1983, it was added to the National Register of Historic Places, where it is listed at 30 Pleasant.

The A. Chapin House is a historic house located at 36 Pleasant Street, in Uxbridge, Massachusetts.

Uxbridge station is a former railroad station in Uxbridge, Massachusetts. Built in 1895, it is a well preserved example of Queen Anne architecture. On October 7, 1983, it was added to the National Register of Historic Places as Uxbridge Passenger Depot. It served as a significant transportation hub and the town's main passenger station for more than 50 years.

Uxbridge Town Hall is the town hall of Uxbridge, Massachusetts, located at 45 South Main Street. It is listed on the National Register of Historic Places. It was built in 1879 and added to the historic registry 100 years later. Amos P. Cutting of Worcester was the architect. Ferry & Gardner of Springfield also submitted plans.An old burial ground had to be relocated to build the town hall. It continues to serve as the administrative headquarters for the town government. In the 1930s its auditorium showed movies, and live bands played here for weekend entertainment. Until recent times it also served as the police headquarters. It was listed on the National Register of Historic Places in 1983.

The Charles Capron House is an historic house at 2 Capron Street in Uxbridge, Massachusetts. Built in 1874, it is an locally distinguished example of Gothic Revival architecture. It is also notable for its association with Charles Capron, a local mill owner. The house was listed on the National Register of Historic Places in 1983.