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Upstate University Hospital is a 752-bed non-profit, teaching hospital located in Syracuse, New York. Upstate University Hospital is a part of the Upstate Health System, as the flagship hospital in the system. As the hospital is a teaching hospital, it is affiliated with the Norton College of Medicine at State University of New York Upstate Medical University. The hospital is also an American College of Surgeons verified Level 1 Trauma Center, the only in the region and one of 21 in New York. Attached to the hospital is the Upstate Golisano Children's Hospital that treats infants, children, teens, and young adults aged 0–21.

The State University of New York Upstate Medical University (SUNY Upstate) is a public medical school in Syracuse, New York. Founded in 1834, Upstate is the 15th oldest medical school in the United States and is the only medical school in Central New York. The university is part of the State University of New York (SUNY) system. SUNY Upstate is an upper-division transfer and doctoral university with degree-granting programs in the Norton College of Medicine (NCOM), College of Health Professions (CHP), College of Graduate Studies (CoGS) and the College of Nursing. As one of 140 academic medical centers in the United States, the Upstate University Health System serves over 1.8 million people annually. Its facilities include Upstate University Hospital, the region's only Level 1 trauma and burn center; Upstate Community Hospital; Golisano Children's Hospital; Upstate Brain & Spine Center; Upstate Heart and Vascular Center; Upstate Cancer Center; and other satellite sites in Central New York.Part of the SUNY system since 1950, Upstate is located in the heart of downtown Syracuse next to Syracuse University. Many of Upstate's faculty provide patient care, teach, and conduct research at the University Hospital. Upstate provides 10,959 jobs, making it Central New York's largest employer. The university adds more than $2.5 billion to the state economy annually. Nearly 7,900 SUNY Upstate alumni physicians are licensed in the United States and they generate more than $24.8 billion in economic activity and support or employ nearly 132,354 employees.

The Institute for Veterans and Military Families (IVMF) is an interdisciplinary research institution that informs and advances the policy, economic and wellness concerns of the America’s veterans and families. It is housed in the National Veterans Resource Center at Syracuse University. The IVMF annually serves thousands of U.S. veterans, service members, and their families around the world and as of 2019, the Institute had served 100,000 military service members, veterans, and their families through their programs.

Crouse College, also known as Crouse Memorial College and historically as John Crouse Memorial College for Women, is a building on the Syracuse University campus. It was funded by John R. Crouse, a wealthy Syracuse merchant (principal donation) with the White family (bankers, secondary doners), and designed by Archimedes Russell. It is built in the Romanesque revival—Richardsonian Romanesque style.The building was listed on the National Register of Historic Places in 1974. It is also one of the historical Comstock Tract buildings on the Syracuse campus. It currently houses Syracuse University's College of Visual and Performing Arts. Chiefly, its classrooms and auditorium are at the service of the Setnor School of Music.

Setnor School of Music, officially The Rose, Jules R., and Stanford S. Setnor School of Music, is one of seven academic units of the College of Visual and Performing Arts of Syracuse University. It is housed primarily in the historical Crouse College building.

Pioneer Homes, in Syracuse, New York, was one of the earliest government public housing projects in the United States. Pioneer Homes was completed in 1941 and remains fully occupied even as another nearby public housing project was demolished. The project consists of 607 apartments, which include both row houses and 3-story walk-ups, all constructed of masonry with brick exteriors in an early modern style. The project is bordered by East Adams Street, Renwick Avenue, Taylor Street, and South Townsend Street. After a rash of drive-by shootings, the Syracuse Common Council voted in 2005 to gate off four out of the five project entrances to reduce traffic and crime. The area is one of concentrated minority poverty, in which Syracuse led the United States as of 2013. That is partially blamed on Interstate 81, which runs through downtown Syracuse and is thought to contribute to segregation. Plans to replace or remove the aging span of I-81, a major concern of the Pioneer Homes Tenant Association, are ongoing, with plans due to be released in early 2019.

The David B. Falk College of Sport and Human Dynamics, simply known as Falk College, is one of the 13 schools and colleges of Syracuse University in Syracuse, New York. Founded in 1917 as the School of Home Economics, Falk College consists primarily of the merger between the College of Human Development, the College of Nursing, and the School of Social Work. The college offers bachelor's, master's degree, and doctoral degree programs in Exercise Science, Food Studies, Human Development and Family Science, Marriage and Family Therapy, Nutrition Science and Dietetics, Public health, Sport Management, and Social Work.

Marshall Street, or "M" Street, is a street in the University Hill neighborhood in Syracuse, New York, adjacent to Syracuse University. Marshall Street often refer to the commercial area including and surrounding the 100 Block of Marshall Street. This area primarily functions as an off-campus commercial area for college students.

University Hill is a neighborhood and business district in Syracuse, New York, located east and southeast of Downtown Syracuse, on one of the larger hills in Syracuse. The neighborhood is bounded on the west by Almond Street and Interstate 81. It continues east to Ostrom Avenue and Thornden Park, where it borders the Westcott and University neighborhoods. Interstate 690 currently serves as the neighborhood's northern boundary.University Hill is the major educational and medical district of Syracuse, as well as an important business district, with three of the top ten employers in the Syracuse region located there. The most expansive of these is Syracuse University, from which the neighborhood's name derives. "The Hill" is also to home a Veterans Administration Medical Center, the State University of New York Upstate Medical University, State University of New York College of Environmental Science and Forestry, as well as Crouse Hospital and the Richard H. Hutchings Psychiatric Center. These five institutions account for over 16,000 full-time positions and over 20,000 students.

Transactional Records Access Clearinghouse (TRAC) is a nonprofit and nonpartisan data gathering, data research, and data distribution organization in the S. I. Newhouse School of Public Communications at Syracuse University.TRAC collects big data from the federal agencies and maintains a databases of federal enforcement, staffing and financial data. TRAC also focuses on using the Freedom of Information Act to request such data. The FOIA Project is an initiative of TRAC that monitors federal agency FOIA decisions and practices.Over the years, TRAC has been cited in hundreds of news articles.

The Syracuse University School of Education is the education school of Syracuse University in Syracuse, New York. Founded in 1906, the school is dedicated to training highly skilled and knowledgeable practitioners, teachers, administrators, counselors, and scholars. The school offers bachelor's, master's, and doctoral degree programs, as well as Certificates of Advanced Study, in elementary education, higher education, special education, school counseling, and educational leadership.

The S. I. Newhouse School of Public Communications, commonly known as Newhouse School, is the communications and journalism school of Syracuse University in Syracuse, New York. It has undergraduate programs in advertising; broadcast and digital journalism; Esports communications and management; magazine, news, and digital journalism; public relations; television, radio and film; visual communications; and music business. Its Master's Programs includes degrees in advanced media management; advertising; audio arts; broadcast and digital journalism; Goldring arts journalism and communications; magazine news and digital journalism; media studies; multimedia, photography and design; public diplomacy and global communications; public relations; and television, radio and film. The school was named after publishing magnate Samuel Irving Newhouse Sr., founder of Advance Publications, who provided the founding gift in 1964.The school enrolls approximately 2,000 undergraduate students, 180 residential master’s degree students, 200 online master's degree students, and 15 doctoral degree candidates as of 2022. Undergraduate admissions are highly selective. The school has about 80 full-time faculty members and about 50 adjunct instructors. Mark J. Lodato has been the dean of the Newhouse School since July 2020.