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Guarino's is a restaurant in the Little Italy section of Cleveland, Ohio and is considered to be the oldest restaurant in Cleveland, founded in 1918 by Vincenzo Guarino.People who have enjoyed the restaurant include Dean Martin and Frank Sinatra.

The Italian American Museum of Cleveland (Italian: Museo Italo Americano di Cleveland; abbreviated as IAMCLE) is a museum in the Little Italy neighborhood of Cleveland, Ohio, emphasizing the heritage, history, identity, and traditions of the city's Italian American community. The museum was founded by veteran Cleveland judges Basil M. Russo and Deborah J. Nicastro on Columbus Day 2020. A soft opening to the public was held in July 2021, with an official grand opening on October 1, 2021. The museum is sponsored by the Italian Sons and Daughters of America (ISDA), and works in partnership with the Western Reserve Historical Society.

Holy Rosary Catholic Church is a historic Catholic parish church in the Little Italy neighborhood of Cleveland, Ohio, United States. Founded in the early 1890s, the parish completed the present Baroque-styled church shortly before 1910; the building has been named a historic site.

The Feast of the Assumption Festival (Italian: Festa dell'assunzione; also locally referred to informally as The Feast (La festa)) is an annual four-day Catholic and Italian American street festival in the Little Italy neighborhood of Cleveland, Ohio, centered on Holy Rosary Church on Mayfield Road near its intersection with Murray Hill Road.

A statue of Rocky Colavito was unveiled in Tony Brush Park, in the Little Italy neighborhood of Cleveland, Ohio, in 2021.

Little Italy–University Circle station (signed as Mayfield Road, Little Italy–University Circle) is a station on the RTA Red Line in the University Circle neighborhood of Cleveland, Ohio. It is located at the Mayfield Road (U.S. Route 322) and East 119 Street intersection, near the western end of Little Italy.

The James A. Garfield Memorial is a memorial for and the final resting place of assassinated President James A. Garfield, located in Lake View Cemetery in Cleveland, Ohio. The memorial, which began construction in October 1885 and was dedicated on May 30, 1890, exhibits a combination of Byzantine, Gothic, and Romanesque Revival architectural styles. Garfield, former First Lady Lucretia Garfield, and two other members of the Garfield family are entombed in the crypt level of the monument. The monument was added to the National Register of Historic Places in 1973.

Wade Memorial Chapel is a Neoclassical chapel and receiving vault located at Lake View Cemetery in Cleveland, Ohio, in the United States. It was donated to the cemetery by Jeptha Wade II in memory of his grandfather, cemetery and Western Union co-founder Jeptha Wade. The overall design was by the newly-founded Cleveland area architectural firm of Hubbell & Benes, and was their first commission. The interior's overall design is by Louis Comfort Tiffany based on a preexisting 1893 design. The interior features two mosaics on the right and left hand walls, and a large stained glass window. Wade Memorial Chapel was added to the National Register of Historic Places on June 18, 1973.

Lake View Cemetery is a privately owned, nonprofit garden cemetery located in the cities of Cleveland, Cleveland Heights, and East Cleveland in the U.S. state of Ohio. Founded in 1869, the cemetery was favored by wealthy families during the Gilded Age, and today the cemetery is known for its numerous lavish funerary monuments and mausoleums. The extensive early monument building at Lake View helped give rise to the Little Italy neighborhood, but over-expansion nearly bankrupted the burial ground in 1888. Financial recovery only began in 1893, and took several years. Lake View grew and modernized significantly from 1896 to 1915 under the leadership of president Henry R. Hatch. The cemetery's cautious management allowed it to avoid retrenchment and financial problems during the Great Depression. Two sites within the cemetery are listed on the National Register of Historic Places. The first is the James A. Garfield Memorial, erected in 1890 as the tomb of assassinated President James A. Garfield. The second is Wade Memorial Chapel, which began construction in 1898 and was completed in 1901. It honors the memory of Jeptha Wade, one of the cemetery's co-founders, and was donated by his grandson.

Euclid–East 120th (signed as East 120th) was a station on the RTA Red Line in the University Circle neighborhood of Cleveland, Ohio. It was located at the Euclid Avenue (U.S. Route 20) and Coltman Road intersection, near the western end of Lake View Cemetery. At the end of service on August 11, 2015, it became the first, and thus far only, station in the history of the RTA to permanently close.

The Cleveland Institute of Art, previously Cleveland School of Art, is a private college focused on art and design and located in Cleveland, Ohio.

The former First Church of Christ, Scientist, located at 2200 Overlook Road, in the University Circle area of Cleveland, Ohio, in the United States is an historic building that was added to the National Register of Historic Places on February 20, 2003. Built from 1929 to 1931 at a cost of $1 million, it was designed by the noted Cleveland firm of Walker and Weeks, who later designed Severance Hall, to which this building is sometimes compared. An unusual feature of the building is its tall minaret-like semi-detached bell tower, which now functions only as a smokestack. Known today as the Nottingham-Spirk Innovation Center, the building is now owned by Nottingham Spirk, which from 2003 to 2005 renovated it for its headquarters. The present First Church of Christ, Scientist building is located at 3181 Fairmount Boulevard in Cleveland Heights.