Manistee Pierhead lights

The Manistee River ( man-iss-TEE), seldom referred to as the Big Manistee River, runs 190 miles (310 km) through the northwestern Lower Peninsula of Michigan; it now passes through the contemporary villages of Sharon, Smithville, and Mesick, entering Lake Michigan at Manistee. It is considered, like the nearby Au Sable River, to be one of the best trout fisheries east of the Rockies. The Manistee River is also being considered for restoration of Arctic grayling, which have been extirpated from the State of Michigan since 1936.

The Manistee Harbor, South Breakwater is a navigational structure located at the mouth of the Manistee River (at Lake Michigan), in Manistee, Michigan. It was listed on the National Register of Historic Places in 1995. The breakwater is significant due to its construction, which represents a final stage in the United States Army Corps of Engineers's use of timber crib substructures in pier and breakwater construction.

The Simeon Babcock House is a private house located at 420 Third Street in Manistee, Michigan.

The Manistee Central Business District is a commercial historic district roughly bounded by Maple, Washington, Water and River Streets in Manistee, Michigan. It was listed on the National Register of Historic Places in 1982.

The Ramsdell Theatre is a historic playhouse theater building and opera house at 101 Maple Street in downtown Manistee, Michigan. The building was financed by local businessman and politician Thomas Jefferson Ramsdell and was built in 1902. It replaced the town's two previous opera houses which had been destroyed by fire, one in 1882 and the other in 1900. Besides producing plays the facility was later used as a movie theater. James Earl Jones started his acting career at the theater as an actor and stage manager.

Guardian Angels Church is a Roman Catholic church located at 371-375 Fifth Street in Manistee, Michigan. It was listed on the National Register of Historic Places in 2020. Along with St. Joseph Church, Guardian Angels Church is part of Divine Mercy Parish in the Diocese of Gaylord.

Manistee ( man-iss-TEE) is a city in the U.S. state of Michigan. Located in southwestern Manistee County, it is part of the northwestern Lower Peninsula. Manistee is the county seat of Manistee County, and its population was 6,259 at the 2020 census. This makes Manistee the fifth-largest city in Northern Michigan. Manistee is located on an isthmus between Manistee Lake and Lake Michigan, with the Manistee River bisecting the city as it flows west to the latter. Manistee is located along US 31, one of the major trunkline highways of the state.

Our Saviour's Evangelical Lutheran Church, also known as the Danish Lutheran Church, is a historic church located at 300 Walnut Street in Manistee, Michigan. The church was added to the National Register of Historic Places in 1972. The building is the oldest existing Danish Lutheran church in the United States.

The First Congregational Church of Manistee, Michigan is a church located at 412 South 4th Street in Manistee, Michigan. It was listed on the National Register of Historic Places in 1974.

Manistee High School is a public secondary school in Manistee, Michigan, United States. It serves grades 6-12 for the Manistee Area Public School District.

The USCGC Acacia (WAGL-406/WLB-406) is an Iris-class 180-foot seagoing buoy tender operated by the United States Coast Guard. Acacia was a multi-purpose vessel, nominally a buoy tender, but with equipment and capabilities for ice breaking, search and rescue, fire fighting, logistics, oil spill response, and other tasks as well. She spent almost all of her 62-year Coast Guard career on the Great Lakes. After decommissioning she became a museum ship in Manistee, Michigan.

SS City of Milwaukee is a Great Lakes railroad car ferry that once plied Lake Michigan, often between Muskegon, Michigan and Milwaukee, Wisconsin. She was built in 1931 for the Grand Trunk Milwaukee Car Ferry Company and is the only pre-1940s ship of this type to survive. She now serves as a museum ship, bed and breakfast, and event venue on the waterfront of Manistee Lake in Manistee, Michigan. She was designated a National Historic Landmark in 1990.