A Great Day in Harlem (photograph)

Langston Hughes House is a historic home located in Harlem, Manhattan, New York City. It is an Italianate style dwelling built in 1869. It is a three story with basement, rowhouse faced in brownstone and measuring 20 feet wide and 45 feet deep. Noted African American poet and author Langston Hughes (1902-1967) occupied the top floor as his workroom from 1947 to 1967.It was listed on the National Register of Historic Places in 1982, and was designated as a city landmark by the New York City Landmarks Preservation Commission in 1981.

Homer Lusk Collyer (November 6, 1881 – March 21, 1947) and Langley Wakeman Collyer (October 3, 1885 – c. March 9, 1947), known as the Collyer brothers, were two American brothers who became infamous for their bizarre natures and compulsive hoarding. The two lived in seclusion in their Harlem brownstone at 2078 Fifth Avenue (at the corner of 128th Street) in New York City where they obsessively collected books, furniture, musical instruments, and myriad other items, with booby traps set up in corridors and doorways to crush intruders. Both died in their home in March 1947 and were found dead (Homer on March 21, Langley not until April 8) surrounded by more than 140 tons of collected items that they had amassed over several decades.Since the 1960s, the site of the former Collyer house has been a pocket park, named for the brothers.

St. Andrew's Episcopal Church is a historic Episcopal church located at 2067 Fifth Avenue at 127th Street in the neighborhood of Harlem in Manhattan, New York City. Built in 1872, it was designed by noted New York City architect Henry M. Congdon (1834–1922) in the Gothic Revival style. It features a 125 foot tall clock tower surmounted by a slate covered spire surrounded by four towerlets.On March 18, 1980, it was added to the National Register of Historic Places. The church was designated as a city landmark by the New York City Landmarks Preservation Commission in 1967. It is still an active parish in the Episcopal Diocese of New York.In 2020, it reported 138 members, average attendance of 32, and $192,540 in plate and pledge income.

The New York College of Podiatric Medicine (NYCPM) is a private podiatric medical college in Manhattan, New York. It is the oldest and second largest podiatric medical school in the United States.

The Mount Morris Bank Building, also referred to as the Corn Exchange Bank (Mount Morris Branch) and Corn Exchange Building, is an historic building in the East Harlem neighborhood of Manhattan, New York City, located at 81-85 East 125th Street on the northwest corner of Park Avenue. Although an architectural standout when new in 1883, by the late 1970s it was vacant, and remained so for three decades, vandalized and deteriorating. In 2009 the city demolished, for safety, most of what remained after a 1997 fire, but in 2012 a developer undertook to rebuild it for commercial occupancy, and the building reopened in May 2015. The building was added to the National Register of Historic Places in 1989, and was designated a New York City Landmark in 1993.

The Harlem–125th Street station is a commuter rail stop serving the Metro-North Railroad's Hudson, Harlem, and New Haven Lines. It is located at East 125th Street and Park Avenue in East Harlem, Manhattan, New York City. The station also serves as an important transfer point between the Metro-North trains and the New York City Subway's IRT Lexington Avenue Line (4, ​5, ​6, and <6> trains) for access to the Upper East Side of Manhattan. It is the only station besides Grand Central Terminal that serves all three lines east of the Hudson River. Trains leave for Grand Central Terminal, as well as to the Bronx and the northern suburbs, regularly.

The Church of All Saints is a historic former Catholic church in the Archdiocese of New York, located at 47 East 129th Street, at the corner of Madison Avenue in the Harlem neighborhood of Manhattan, New York City. Built from 1883 to 1886 and designed by architects Renwick, Aspinwall and Russell – but attributed by historian Michael Henry Adams directly to James Renwick, Jr. – the church complex includes a parish house (1886–89) as well as a school (1902) designed by Renwick's nephew, William W. Renwick.The complex was designated a New York City landmark by the New York City Landmarks Preservation Commission in January 2007.On May 8, 2015, the parish was merged with that of St. Charles Borromeo, and on June 30, 2017, the church was deconsecrated.On January 23, 2021, the New York Post reported that the complex is to be sold, and a final sale at $11M was announced by Fr Greg Chisholm, SJ on April 1.

The Jordan L. Mott House was a mansion located on 2122 Fifth Avenue, near 130th Street in the Harlem area of Manhattan, New York City.

The National Jazz Museum in Harlem is a museum dedicated to preservation and celebration of the jazz history of Harlem, Manhattan, New York City. The idea for the museum was conceived in 1995. The museum was founded in 1997 by Leonard Garment, counsel to two U.S. presidents, and an accomplished jazz saxophonist, Abraham David Sofaer, a former U.S. district judge who gave the initial gift in honor of his brother-in-law Richard J. Scheuer, Jr., and matching funds from the Upper Manhattan Empowerment Zone Development Corporation. For more than 15 years, the museum was based in East Harlem at 104 East 126th Street. On February 1, 2016, the museum re-opened in a new space on the ground floor of 58 West 129th Street in Central Harlem with approximately 1900 square feet of exhibition space.

The Children's Storefront was a tuition-free private school in Harlem, founded in 1966 by the poet Ned O'Gorman. It was the subject of a 1988 documentary film, The Children's Storefront, nominated for an Academy Award for Best Documentary Short.

The Columbus Theatre was a theatre located at 114 E. 125th Street between Park Avenue and Lexington Avenue. It was the second theatre built by theatre impresario Oscar Hammerstein I. The architects were J. B. McElfatrick & Sons.The Columbus Theatre originally sat 1,649 people and was a major venue for musical theatre, vaudeville, and minstrel shows in Upper Manhattan. The theatre also occasionally served as an opera house, and sometimes presented plays ranging from classic works by William Shakespeare to new plays written by Americans. It opened in October 1890. The theatre was sold to F. F. Proctor in 1899 and was then renamed Proctor's 125th Street Theatre. It was later re-titled Keith & Proctor's 125th Street Theatre about a year later when Proctor formed a partnership with Benjamin Franklin Keith. After that partnership fell apart in 1911, it was once again known as Proctor's 125th Street Theatre or simply Proctor's Theatre. It was purchased by RKO sometime in the 1930s, and operated as a move theatre entitled RKO Proctor's 125th Street Theatre until it closed in 1957.

The Caribbean Cultural Center African Diaspora Institute (CCCADI) is a nonprofit organization based in East Harlem in New York City that serves as an Afro-Caribbean center of culture and community for members of the African diaspora.