Puente Juan Bosch

Pedro Francisco Bono Institute (ISB) (formerly Pedro Francisco Bonó Philosophical Institute) began in September 1985 offering philosophical and humanities studies for Jesuits preparing for the priesthood. Classes were held at the San Pedro Claver Juniorate on Samana Street, Santo Domingo, Dominican Republic. In 1989 the Institute moved to its present location and began offering the Bachelor of Arts and Philosophy degree. It is a member of the Association of Universities Entrusted to the Society of Jesus in Latin America (AUSJAL) and is affiliated with the Pontifical Gregorian University.

The Santa Bárbara Military Cathedral is a colonial Eclectic Catholic cathedral dedicated to Saint Barbara that is located in the Ciudad Colonial of Santo Domingo, in the Dominican Republic. Its official name is Santa Iglesia Catedral Castrense Santa Bárbara de los Hombres de la Mar (Cathedral Military Saint Church Saint Barbara of the Men of the Sea). It is located in the Santa Bárbara de los Hidalgos Canteros sector, at the intersection of calle Isabel La Católica with calle General Gabino Puello, right on the edge of the Wall that protected the first Spanish viceroyalty in the New World.

The Reales Atarazanas (Royal Shipyards) is a waterside building that housed the shipyards, warehouses, customs house and tax offices of the old port of Santo Domingo, Dominican Republic. It was the property of the Spanish Crown. Begun in 1509, the Atarazanas is the oldest building of its type still standing in America, and one of a handful remaining in the Spanish world, amongst which are the Atarazanas Reales de Barcelona, in Barcelona, the Atarazanas Reales de Sevilla, in Seville, the Atarazanas del Grao in Valencia and the Royal Dockyard in Havana.The Atarazanas building is part of Colonial City of Santo Domingo World Heritage Site, and after restoration in 2018, today houses the Museo de las Atarazanas Reales, which reopened in December 2019 and exhibits artifacts recovered from underwater archaeology and other artifacts from colonial shipwrecks around Hispaniola island and the naval history of the Dominican Republic.

The Alcázar de Colón, or Columbus Alcazar is the first fortified European palace built in the Americas. It is located in the Dominican Republic's colonial area of Santo Domingo city, and forms part of the Ciudad Colonial UNESCO's World Heritage Site. It was built between 1510 and 1514 mostly in a Gothic and Renaissance style. It is the only known residence of a member of the Christopher Columbus family in the New World, his first-born son Diego Columbus, whose children Juana, Isabel, Luis and Christopher were born in the palace. Diego Columbus died in Spain in 1526 but María Álvarez de Toledo, his widow, remained there until her death in 1549. Three generations of the Columbus family inhabited the residence, possibly until the late 16th century. The Tapestry collection (spanning from the 15th to 17th centuries) is particularly important and unique in the Caribbean, and includes pieces produced by the Flemish Van Den Hecke family from cartouches created by Charles Le Brun. The Alcázar is the most visited museum in Santo Domingo.

Santo Domingo Este is a municipality and the provincial capital of the Santo Domingo province in the Dominican Republic. It has one municipal district (distrito municipal), San Luis.Santo Domingo Este is across the Ozama River which divides the east and west sections of metropolitan Santo Domingo. This eastern side is more residential and less commercially developed, but it too has experienced growth, though at a slower pace than Santo Domingo itself, with new malls and department stores.

The Plaza de España, also known as the Plaza de la Hispanidad, is a public square located in the historic district of Ciudad Colonial, Santo Domingo, Dominican Republic. To its north lies the historic Alcázar de Colón, dating back to 1514, and to the south, the Museo de las Casas Reales, built in 1511. The plaza is a popular gathering spot in the city, surrounded by a variety of restaurants and outdoor terraces. Due to its large size, it is also a popular venue for concerts and festivals.

Monasterio de San Francisco in Santo Domingo de Guzmán, Dominican Republic, is a monastery that was built between 1508–1560, with the arrival of the Franciscan fathers. The ruin is one of the most important of the city. It is located in the Colonial City of Santo Domingo and are part of UNESCO's 1990 declaration of the Colonial City as a World Heritage Site. The monastery was recognized by UNESCO for being the first and oldest monastery built in the Americas.

The Casa del Cordón (Spanish for "House of the Cord") is a property located in the Colonial City of Santo Domingo, in the Dominican Republic. It is the oldest European stone house in the Americas and probably the first European two-story house. Its name is due to the chiseled sash-and-cord that it presents on its façade, which is associated with the Franciscan Order. It is located on Isabel la Católica street with the corner of Emiliano Tejera. In 1586, During the Francis Drake's incursion, the balance was installed inside this house with which the belongings that the inhabitants of the city had to deliver to the English pirate were weighed.This is an Isabelline Gothic and Mudéjar style building. It is part of the UNESCO World Heritage Site "Colonial City of Santo Domingo".

The National Pantheon was built from 1714 to 1746 by the Spaniard Geronimo Quezada y Garçon and was originally a Jesuit church. The structure was constructed in the neoclassic-renaissance style. Today, the structure stands as a national symbol of the Dominican Republic and serves as the final resting place of the Republic's most honored citizens.

The Hospital San Nicolás de Bari is a preserved hospital ruin, and it was recognized by UNESCO for being the oldest hospital built in the Americas. Construction began in 1503 in Santo Domingo, Dominican Republic, at the behest of governor (and namesake of the hospital) Nicolás de Ovando. This grand project was in keeping with the desire to emulate European princely courts, and looked to Renaissance Italy for inspiration. At the time of its completion, the wards could accommodate up to 70 patients, comparable to the most advanced churches of Rome. It is likely that the model for the Hospital de San Nicolás was the large Ospedale di Santo Spirito in Sassia in Rome. The complex forms part of the Colonial Zone of Santo Domingo World Heritage Site.

National School of Visual Arts (Spanish: Escuela Nacional de Artes Visuales; ENAV) is an institution in the field of visual arts in the Dominican Republic. It was inaugurated on August 19, 1942. It is located in Santo Domingo.

Parque Colón (Spanish pronunciation: [ˈpaɾke koˈlon]; lit. 'Columbus Park') is the central square of the Ciudad Colonial historic district of Santo Domingo, Dominican Republic. In its center stands a statue of Christopher Columbus, in whose honor the square was renamed in 1887. Previously the square was known as Plaza Mayor. Monuments bordering the square include the Catedral de Santa Maria la Menor, Santo Domingo's Palace, and the Palacio Borgella, which once hosted the Dominican Republic's Parliament. Calle del Conde, once the thriving commercial heart of Santo Domingo, starts from Parque Colón and runs to the Puerta del Conde. At the beginning of Calle del Conde is a bust of Bartholomew Columbus, Christopher's brother and the founder of Santo Domingo.