Building 470

The One-Million-Liter Test Sphere—also known as the Test Sphere, the Horton Test Sphere, the Cloud Study Chamber, Building 527, and the "Eight Ball" (or "8-ball")—is a decommissioned biological warfare (BW) chamber and testing facility located on Fort Detrick, Maryland, US. It was constructed and utilized by the U.S. Army Biological Warfare Laboratories as part of its BW research program from 1951 to 1969. It is the largest aerobiology chamber ever constructed and was placed on the National Register of Historic Places in 1977.

The U.S. Army Biological Warfare Laboratories (USBWL) was a suite of research laboratories and pilot plant centers operating at Camp (later Fort) Detrick, Maryland, United States, beginning in 1943 under the control of the U.S. Army Chemical Corps Research and Development Command. The USBWL undertook research and development into biocontainment, decontamination, gaseous sterilization, and agent production and purification for the U.S. offensive biological warfare program. The laboratories and their projects were discontinued in 1969.

Fort Detrick () is a United States Army Futures Command installation located in Frederick, Maryland. Fort Detrick was the center of the U.S. biological weapons program from 1943 to 1969. Since the discontinuation of that program, it has hosted most elements of the United States biological defense program.As of the early 2010s, Fort Detrick's 1,200-acre (490 ha) campus supports a multi-governmental community that conducts biomedical research and development, medical materiel management, global medical communications and the study of foreign plant pathogens. The lab is known to research pathogens such as Ebola and smallpox.It is home to the U.S. Army Medical Research and Development Command (USAMRDC), with its bio-defense agency, the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). It also hosts the Frederick National Laboratory for Cancer Research and is home to the National Interagency Confederation for Biological Research (NICBR), National Interagency Biodefense Campus (NIBC) and the National Center for Medical Intelligence (NCMI). In August 2019, its deadly germ research operations were shut down following serious safety violations, in particular relating to the disposal of dangerous materials.Fort Detrick is the largest employer in Frederick County, Maryland.

The National Biodefense Analysis and Countermeasures Center (NBACC) is a government biodefense research laboratory created by the U.S. Department of Homeland Security (DHS) and located at the sprawling biodefense campus at Fort Detrick in Frederick, MD, USA. The NBACC (pronounced EN-back) is the principal U.S. biodefense research institution engaged in laboratory-based threat assessment and bioforensics. NBACC is an important part of the National Interagency Biodefense Campus (NIBC) also located at Fort Detrick for the US Army, National Institutes of Health and the US Department of Agriculture.

The United States Army Medical Research Institute of Infectious Diseases (USAMRIID; ) is the U.S Army's main institution and facility for defensive research into countermeasures against biological warfare. It is located on Fort Detrick, Maryland, near Washington, D.C., and is a subordinate lab of the United States Army Medical Research and Development Command (USAMRDC), headquartered on the same installation. USAMRIID is the only U.S. Department of Defense (DoD) laboratory equipped to study highly hazardous viruses at Biosafety Level 4 within positive pressure personnel suits. USAMRIID employs both military and civilian scientists as well as highly specialized support personnel, totaling around 800 people. In the 1950s and 1960s, USAMRIID and its predecessor unit pioneered unique, state-of-the-art biocontainment facilities which it continues to maintain and upgrade. Investigators at its facilities frequently collaborate with the Centers for Disease Control and Prevention, the World Health Organization, and major biomedical and academic centers worldwide. USAMRIID was the first bio-facility of its type to research the Ames strain of anthrax, determined through genetic analysis to be the bacterium used in the 2001 anthrax attacks.

Schifferstadt, Also known as Scheifferstadt, is the oldest standing house in Frederick, Maryland. Built in 1758, it is one of the nation's finest examples of German-Georgian colonial architecture. It was designated a National Historic Landmark in 2016.

Hood College is a private college in Frederick, Maryland. In fall 2018, Hood enrolled 2,052 students (1,092 undergraduate students; 960 graduate students). Thirty-eight percent of students are either members of under-represented racial or ethnic populations or from foreign countries.It was established in 1893 by the Potomac Synod of the Reformed Church in the United States as the Woman's College of Frederick. An all-female institution until 1971, the college initially admitted men only as commuters. This continued until 2003, when male students were extended the option of residential status.

Culler Lake is a man-made lake in Frederick, Maryland. The lake is used as part of stormwater management and it is also a gathering place for community recreation and it was restored and revitalized in 2016. The lake is located in Baker park.

Frederick High School (FHS) is a four-year public high school in the city of Frederick in Frederick County, Maryland, United States. A National Blue Ribbon School of Excellence, Frederick High is the oldest school in Frederick County, the school's diverse population reflects its surrounding dynamic community. Frederick High School opened in 1891 with girls and boys attending school in different buildings and matriculation occurring after three years. The former facility opened in 1939 and was demolished in 2018, with the current building opening in the fall of 2018. The school serves the city of Frederick along with Governor Thomas Johnson High School and Tuscarora High School.

Frederick Health Hospital is the only hospital in Frederick County, Maryland. It is located in the city of Frederick.

The Nallin Farm Springhouse and Bank Barn are closely associated with the Nallin Farm House on the grounds of Fort Detrick, Maryland, US. The barn is a good example of a fieldstone-built bank barn with a byre on the lower level and an earth ramp on the opposite side providing access to a haymow.The simple stone springhouse is the source of 3+1⁄2-acre Nallin Pond. The barn and springhouse were built c. 1800. The Nallin Farm Springhouse and Bank Barn was listed on the National Register of Historic Places in 1977.The barn has a hay hood, as can be seen in the 14th of 17 photos included in the nomination.

The James K.P. Wolfe House is a historic home in Frederick, Maryland. It is a two-story, frame, single hall plan, Victorian period farmhouse with Gothic Revival-style detailing. It is a late-19th century example of the Maryland Piedmont farmhouse. The dwelling was built in 1889 by the Wolfe family, who owned the property until 1936.It was listed on the National Register of Historic Places in 2002.