Community Artists' Collective

Isabella Court is a Spanish Colonial Revival style mixed-use residential and commercial complex at 3909-3917 South Main Street in the Midtown district of Houston, Texas, United States. It is listed in the National Register of Historic Places. Isabella Court's residents mainly consist of artists and other professionals. As of 2009 Trudy Hutchings owns the complex.

The Buffalo Soldiers National Museum, located in Houston, Texas, is a museum dedicated to the history and achievements of Buffalo Soldiers and African American soldiers from all of the branches of the United States Military.

The Houston Light Guard was one of the oldest militia companies founded in Texas. Founded in 1873, it served as Company G of the 143rd Infantry Regiment during both World Wars, was apart of the National Guard's one and only Airborne Infantry Brigade, a Ranger Company, and a Long Range Surveillance Company.

The Ion District, Ion Innovation District, or Rice Innovation District, is a technology park and innovation district in Midtown Houston which was established as a joint initiative between Rice University and the City of Houston. It has also been called the South Main Innovation District. The district's central hub and first building is the Ion, which opened in 2021 after owner Rice Management Company (RMC) converted it from a former Sears store. The building houses coworking and office spaces, business incubators and accelerators, classrooms, a prototyping lab, investor studio, and restaurants. Current tenants include Chevron Technology Ventures and Microsoft. The district also includes Greentown Labs Houston, a business incubator focused on climate technology and sustainable energy, and a large outdoor plaza. RMC, a division of Rice University, is leading development of the project. Some community members, concerned about the potential gentrification of the nearby Third Ward, a predominantly African-American community, have expressed a range of concerns about the project.

South Main Baptist Church is a Baptist church in Houston, Texas. Located in Houston's midtown area, the church has a long history in the city. The church was named "Church of the Year" by Guideposts Magazine.

Wheeler Station is a station on the METRO Red Line in Houston. The station is located at the intersection of Main Street and Wheeler Street in Midtown.While construction and funding has not yet been finalized for the METRORail University/Blue Line, transfers between it and the Red Line will occur here if and when the Blue Line is built. Prior to the construction of the METRORail Purple Line, Wheeler Station was the only station in the system that had platforms that faced each other. UH South/University Oaks station became the second station to implement this platform configuration.

San Jacinto High School was a secondary school located at 1300 Holman Street in Houston, Texas; now part of the Houston Community College Central College, Central Campus. San Jacinto High School was located in the area now known as Midtown. It was a part of the Houston Independent School District (HISD). It was listed on the National Register of Historic Places (NRHP) on December 4, 2012.

The Ensemble Theatre, located in the heart of midtown at 3535 Main Street in Houston, Texas, is the largest African-American professional theatre company in the United States that produces plays in-house and owns its own facility.

Ensemble/HCC is an island platformed METRORail light rail station in Houston, Texas, United States. The station was opened on January 1, 2004, and is operated by the Metropolitan Transit Authority of Harris County, Texas (METRO). Located Midtown, this station is close to both the Houston Community College System's Central College campus and The Ensemble Theatre, which together give the station its name. The station was to have originally been called Berry/HCC due to its location at the intersection of Main and Berry Streets near the Houston Community College Central Campus. However, Ensemble/HCC was chosen as the official name after Houston mayor Lee P. Brown presented a proposal from The Ensemble Theatre to include their name in the station naming. This is the only station to have its name altered from the original ones proposed by METRO.

The Montrose Center is an LGBTQ community center located in Houston, Texas, in the United States. The organization provides an array of programs and services for the LGBTQ community, including mental and behavioral health, anti-violence services, support groups, specialized services for youth, seniors, and those living with HIV, community meeting space, and it now operates the nation's largest LGBTQ-affirming, affordable, senior living center in the nation, the Law Harrington Senior Living Center. It is a member of the National Coalition of Anti-Violence Programs. It is in Neartown (Montrose).

Trinity Church, in Midtown Houston, Texas, is a parish church in the Episcopal Diocese of Texas.

Contemporary Learning Center (CLC) was a secondary school located in Houston, Texas, United States. CLC closed in 2011. It was replaced by DeVry Advantage Academy, operated in association with DeVry University. CLC, which serves grades 7 through 12, is a part of the Houston Independent School District. CLC was located in the Third Ward area, near Midtown.CLC served students who do not succeed in traditional school environments and need more academic motivation and better attendance records.CLC included Houston Night High School, Houston ISD's evening high school program. The school, which served grades 9–12, opened in 1975 and closed in the summer of 2007.