Buffalo Soldiers National Museum

The Houston Light Guard was one of the oldest militia companies founded in Texas. Founded in 1873, it served as Company G of the 143rd Infantry Regiment during both World Wars, was apart of the National Guard's one and only Airborne Infantry Brigade, a Ranger Company, and a Long Range Surveillance Company.

The Community Artists' Collective is a non-profit exhibition space based in Houston, Texas, USA, focused on exhibiting work by African American artists and creating more opportunities for children and adults to explore the arts.

San Jacinto High School was a secondary school located at 1300 Holman Street in Houston, Texas; now part of the Houston Community College Central College, Central Campus. San Jacinto High School was located in the area now known as Midtown. It was a part of the Houston Independent School District (HISD). It was listed on the National Register of Historic Places (NRHP) on December 4, 2012.

Isabella Court is a Spanish Colonial Revival style mixed-use residential and commercial complex at 3909-3917 South Main Street in the Midtown district of Houston, Texas, United States. It is listed in the National Register of Historic Places. Isabella Court's residents mainly consist of artists and other professionals. As of 2009 Trudy Hutchings owns the complex.

The Ensemble Theatre, located in the heart of midtown at 3535 Main Street in Houston, Texas, is the largest African-American professional theatre company in the United States that produces plays in-house and owns its own facility.

Ensemble/HCC is an island platformed METRORail light rail station in Houston, Texas, United States. The station was opened on January 1, 2004, and is operated by the Metropolitan Transit Authority of Harris County, Texas (METRO). Located Midtown, this station is close to both the Houston Community College System's Central College campus and The Ensemble Theatre, which together give the station its name. The station was to have originally been called Berry/HCC due to its location at the intersection of Main and Berry Streets near the Houston Community College Central Campus. However, Ensemble/HCC was chosen as the official name after Houston mayor Lee P. Brown presented a proposal from The Ensemble Theatre to include their name in the station naming. This is the only station to have its name altered from the original ones proposed by METRO.

Trinity Church, in Midtown Houston, Texas, is a parish church in the Episcopal Diocese of Texas.

South Main Baptist Church is a Baptist church in Houston, Texas. Located in Houston's midtown area, the church has a long history in the city. The church was named "Church of the Year" by Guideposts Magazine.

The Ion District, Ion Innovation District, or Rice Innovation District, is a technology park and innovation district in Midtown Houston which was established as a joint initiative between Rice University and the City of Houston. It has also been called the South Main Innovation District. The district's central hub and first building is the Ion, which opened in 2021 after owner Rice Management Company (RMC) converted it from a former Sears store. The building houses coworking and office spaces, business incubators and accelerators, classrooms, a prototyping lab, investor studio, and restaurants. Current tenants include Chevron Technology Ventures and Microsoft. The district also includes Greentown Labs Houston, a business incubator focused on climate technology and sustainable energy, and a large outdoor plaza. RMC, a division of Rice University, is leading development of the project. Some community members, concerned about the potential gentrification of the nearby Third Ward, a predominantly African-American community, have expressed a range of concerns about the project.

First Lutheran in Houston (also known as First Evangelical Lutheran Church in Houston) is a historic Lutheran church at 1311 Holman Street in Houston, Texas. It is part of the North American Lutheran Church (NALC). The current church building was constructed in 1927 in a Lombard Romanesque style. The church building was added to the National Register of Historic Places in 2006.

The Houston Community College System Foundation was founded in 1976 to provide scholarships to Houston Community College students and to support the college's efforts to attract and educate Houston-area students—including many non-traditional students and those facing barriers to higher education. Like virtually all community college foundations, for most of its existence the HCCS Foundation functioned primarily as a clearinghouse for scholarships, accepting funds from donors and awarding them to eligible students. It was not expected to engage in large-scale solicitation of funds. Much has changed since the HCCS Foundation's establishment. Higher education has become a requirement for earning a stable living, and businesses have begun clamoring for a more educated workforce. At the same time, tuition and fees at four-year institutions have skyrocketed, and Houston's demographics have shifted, with the majority of the city's young people now coming from backgrounds historically unlikely to receive higher education. In 2007, the HCCS Foundation launched a website, and was reclassified by the Internal Revenue Service as a Section 509(a)(1) and 170(b)(1)(A)(vi) publicly supported charity.

Wheeler Station is a station on the METRO Red Line in Houston. The station is located at the intersection of Main Street and Wheeler Street in Midtown.While construction and funding has not yet been finalized for the METRORail University/Blue Line, transfers between it and the Red Line will occur here if and when the Blue Line is built. Prior to the construction of the METRORail Purple Line, Wheeler Station was the only station in the system that had platforms that faced each other. UH South/University Oaks station became the second station to implement this platform configuration.