Chicago, Rock Island & Pacific Railroad Depot (Des Moines, Iowa)

The Rumely–Des Moines Drug Company Building at 110 SW. Fourth St. in Des Moines, Iowa is a large brick warehouse block building. It is a work of architects Hallett & Rawson. It has also been known as the Rumely Bldg, as the Federal Machine Corp Bldg, and as the Security File Warehouse Building. It was listed on the National Register of Historic Places in 1989.

The Earle & LeBosquet Block, also known as the Redhead & Wellslager Block, is a historic building located in Des Moines, Iowa, United States. Completed in 1896, the building is a fine example of the work of Des Moines architect Charles E. Eastman. It shows Eastman's ability to use Neoclassical forms and integrate the more modern Chicago Commercial style. It is also an early use of terra cotta for architectural detailing and buff-colored brick for the main facade in Des Moines, which became widespread in the city in the following decades. The main floor housed two commercial spaces and the upper floors were used for warehouse space. The four-story structure was built by local contractor Gerrit Van Ginkel, and it was owned by attorneys Ira M. Earle and Peter S. LeBosquet. It replaced a three-story brick building that was built at this location in 1876. The building was listed on the National Register of Historic Places in 2009.

The Polk County Courthouse located in Des Moines, Iowa, United States, was built in 1906. It was listed on the National Register of Historic Places in 1979 as a part of the County Courthouses in Iowa Thematic Resource. The courthouse is the third building the county has used for court functions and county administration.

The Randolph Hotel or Hotel Randolph is a nine-story hotel located in Des Moines, Iowa, United States. This hotel was designed and built by the H.L. Stevens & Company in 1911. It rents rooms for a weekly rate. Most guests are considered long term, meaning they stay for more than thirty consecutive days. The Randolph Hotel is located on the corner of Fourth Street and Court Avenue downtown, along the historic Court Avenue strip. It is an eight-story hotel "constructed in 1912 as the first tall and only 'absolutely fireproof hotel' in the city" of Des Moines, Iowa. Ironically there was a fire on 2-19-2010. It is located at 200-204 4th Street in the downtown commercial district of Des Moines.The property was added to the National Register of Historic Places (NRHP) on June 11, 2009, and the listing was announced as the featured listing in the National Park Service's weekly list of June 19, 2009.In 2008, rehabilitation of the building into low- and moderate-income rental housing, to be funded in part by federal and state historic preservation tax credits, was planned.

The Seth Richards Commercial Block, also known as the Lederer-Strauss Building, is an historic building located in downtown Des Moines, Iowa, United States. Its construction represents the transition of Court Avenue from a retail center to the city's wholesale district. Seth Richards had acquired the property that had been the location of several business houses. One of the lots had been owned by the Independent Order of Odd Fellows. The four-story, brick, Romanesque Revival building was constructed in two parts. The commercial blocks at 300-302 and 304-306 were completed and occupied in 1890, and 308-310 was completed and occupied by 1897. Various wholesale clothing firms occupied the various blocks, but by 1920 Lederer, Strauss & Co., Inc., a millinery fabricator and wholesaler, occupied the entire building. The family-run business was sold in 1944 to the Hiersteiners, who incorporated the business as the Landsco Millinery Co. The business was scaled back, and they occupied less of the block, which was filled with other wholesalers by the mid-1950s. In 1957 the Landsco Millinery Co. was liquidated. The building has been converted for other retail uses in the Court Avenue Entertainment District after this area ceased being a wholesale center. It was listed on the National Register of Historic Places in 2005.

The Hawkeye Insurance Company Building is a historic building located in Des Moines, Iowa, United States. Completed in 1869, the building housed the first successful casualty insurance company in the city, which grew to be the largest center for insurance companies outside of the east coast. Prominent local architect William Foster designed the building, and it may be the oldest surviving example of his work. It is also the oldest commercial building in the downtown area that maintains its original integrity.The three-story brick commercial block was designed to be the first part of a larger complex. The Italianate style building features a bracketed cornice and tall thin hooded windows. A two-story annex was completed two years later to the north. Two more three-story sections were completed before 1883. Another prominent Des Moines architectural firm, Proudfoot, Bird and Rawson, converted the building into a hotel in 1913. The original cornice was significantly altered and the raised basement was eliminated at that time. The building was later converted into an apartment building in the 1960s. In the 1980s the cornice was restored. The building was listed on the National Register of Historic Places in 1986.

The Des Moines Saddlery Company Building is an historic building located in downtown Des Moines, Iowa, United States. It was built in 1881 by J. Rubelman of Muscatine, Iowa. He choose to move his operation to Des Moines because of its location on two rivers and the 13 railroads that served the city. It was one of four saddlery firms in a two block area. Rubelman's company made saddles, harnesses and leather works for 20 years. In the years since it has housed a shoe maker, rubber company, stove manufacturer, glove company, the Krispy Kone Company and the Kaplan Hat Company. The later was also the name of the restaurant that was located on the first floor. The building, which was built in four phases between c. 1878 to 1920, is the most intact example of commercial Italianate architecture extant in Des Moines. It was built to house both retail and manufacturing purposes. The building was flooded with 19 feet (6 m) of water during the Des Moines River flood of 1993. It remained empty until the Court Avenue Restaurant & Brewing Company moved in with its equipment. The Des Moines Saddlery Company Building was listed on the National Register of Historic Places in 1985.In 2016, the Republic of Kosovo selected the Saddlery Company Building to host a consulate office.

Youngerman Block is a three-story commercial building in downtown building in Des Moines, Iowa, incorporating Italianate architecture, with later alterations that introduced Art Deco detailing. Built in 1876, the Youngerman Block was designed by architect William Foster (1842-1909) for Conrad Youngerman.

The Fifth is a skyscraper under construction in Des Moines, Iowa. Developed by Mandelbaum Properties, upon completion in 2022, it will be the second tallest building in Iowa. The building will consist of a movie theater, hotel, parking garage, retail, and residential space. Construction started in late 2018 and is expected to finish at the end of 2022.

The Taft–West Warehouse, also known as the C.C. Taft Company Building, Plumb Supply Company, Ben's Furniture Warehouse, and Nacho Mamma's, is a historic building located in Des Moines, Iowa, United States. Completed in 1923, this three-story brick structure was built during a transitional period between the dominance of railroads the emergence of trucks servicing warehouses. It was designed by local architectural firm of Vorse, Kraetsch, & Kraetsch. It features cleans lines of the Commercial style as opposed to the fussiness of late Victorian styling that was dominant in a great deal of the city's commercial architecture. The building was also located in the Court Avenue wholesale district, and now it is only one of only five or six that remain extant. The building was constructed for the C.C. Taft Company. This firm and the O.B. West Company that succeeded it in this building, dealt in wholesale fruits, vegetables, candy and tobacco. The building was listed on the National Register of Historic Places in 2006.

The Plaza Building, also known as The Plaza Condominiums, is a high-rise condominium building located in downtown Des Moines, Iowa, United States. The building rises 25 floors and 340 feet (104 m) in height. It is currently the 5th-tallest building in the city, but will soon be the 6th after the completion of the skyscraper, The Fifth which will only be a couple blocks away. Designed by the architectural firm of Stageberg Beyer Sachs, Inc., the building was completed in 1985. It is essentially a modernist building, but it exhibits elements of the Postmodern style. These are found in the light and dark colored banding at the base and the blue hipped and gabled roof.

The Boyt Company Building, also known as the Gilchrist Building, is a historic building located in Des Moines, Iowa, United States. The significance of this two-story brick structure is its association with the Boyt Company. Boyt manufactured leather goods in this building from 1904, when it was built, until 1908. They moved to a now nonextant building to the west at that time. From 1943 to 1945 Boyt was a contractor with the United States Armed Forces, and they leased this building as a depot for shipping supplies. They supplied leather and canvas goods to the Marine Corps, the Navy Department, Signal Corps, Rock Island Arsenal and Ordnance Department, the Army Air Force, and the Treasury Department, among others. The building was remodeled sometime in the 1910s or 1920s when the brick, including its simple cornice, was covered with stucco. It was remodeled again in 1980 when vertical wood siding was placed over the stucco. The building, along with the alley that connected it with Boyt's nonextant building, was listed on the National Register of Historic Places in 2009.