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Alt-Berlin ("Old Berlin"), also spelled Altberlin, is a neighborhood (Stadtviertel), situated in the Berliner locality (Ortsteil) of Mitte, part of the homonymous borough. In the 13th century it was the sister town of the old Cölln, located on the northern Spree Island in the Margraviate of Brandenburg. It counts in its territory the zone of Nikolaiviertel.

The Greater Berlin Act (German: Groß-Berlin-Gesetz), officially Law Regarding the Creation of the New Municipality of Berlin (German: Gesetz über die Bildung einer neuen Stadtgemeinde Berlin), was a law passed by the Prussian state government in 1920, which greatly expanded the size of the Prussian and German capital of Berlin.

The Rotes Rathaus (German: [ˈʁoːtəs ˈʁaːtˌhaʊs], Red City Hall) is the town hall of Berlin, located in the Mitte district on Rathausstraße near Alexanderplatz. It is the home to the governing mayor and the government (the Senate of Berlin) of the state of Berlin. The name of the landmark building dates from the façade design with red clinker bricks.

The Hemp Museum (German: Hanf Museum Berlin) was opened in Berlin on 6 December 1994. It is the only museum in Germany focused on the cannabis plant. The museum also actively promotes the protection of children and young people and offers individually tailored tours of the exhibition with care staff. It serves as a meeting place for the organisers of the Hanfparade. The Hanf Museum regularly takes part in the "Long Night of Museums", the Berlin Fairytale Days and the Historale which takes place in the Nikolai Quarter. In 2017, the Hanf Museum took part in the Kirchentag in Berlin as a self-organised event on the topic of the war on drugs with speakers from South American victims, including the Reverend Martin Diaz from El Salvador.

The Raid on Berlin took place in October 1760 during the Third Silesian War (part of the Seven Years' War) when Austrian and Russian forces occupied the Prussian capital of Berlin for several days. After raising money from the city, and with the approach of further Prussian reinforcements, the occupiers withdrew. There were later allegations that the Russian commander Count Tottleben had received a personal bribe from the Prussians to spare the city, and he was subsequently tried and found guilty of being a spy.

Rotes Rathaus is a subway station in Berlin's Mitte district. It is part of the extension of the U5 from Alexanderplatz to Brandenburger Tor, construction of which began with a turf-cutting ceremony in 2010. The station and the line opened simultaneously on 4 December 2020.

The St. Nikolai-Kirche, (Nikolaikirche or St. Nicholas' Church) is the oldest church in Berlin, the capital of Germany. The church is located in the eastern part of central Berlin, the borough of Mitte. The area around the church, bounded by Spandauer Straße, Rathausstraße, the River Spree and Mühlendamm, is known as the Nikolaiviertel 'Nicholas quarter', and is an area of restored medieval buildings (in some cases recent imitations). The church was built between 1220 and 1230, and is thus, along with the Church of Our Lady at Alexanderplatz not far away, the oldest church in Berlin.

Molkenmarkt (literally: "whey market") is the oldest square in Berlin. It is located in the Alt-Berlin quarter of the Mitte district, in the historic centre of the city. With approximately 9,200 square metres (11,000 sq yd) in size, it is today a major traffic junction, dominated by the large Altes Stadthaus administrative building on its southeastern side.

Zum Nußbaum is a historic inn in Berlin, Germany. Formerly located in Fischerinsel, after its destruction in World War II it was recreated in the nearby Nikolaiviertel. The inn, originally located at Fischerstraße 21, was built either in 1505 or in 1705, according to different interpretations of the inscription over the cellar entrance. It was named for the nut tree which formerly stood outside it and was one of the oldest drinking establishments in the city. It was popular with tourists and had been frequented and depicted by artists such as Heinrich Zille and Otto Nagel. The inn was destroyed in an Allied air-raid in 1943, along with most of the surrounding area. It was recreated in 1987 in the nearby Nikolaiviertel as part of the East German creation of a tourist old town there. It is adjacent to the Nikolaikirche (St. Nicholas' Church).

Founded about 1200, the Nikolaiviertel (Nicholas' Quarter) of Alt-Berlin, together with nearby Cölln, jointly make up the reconstructed historical heart of the German capital of Berlin. It is located in Mitte locality (in the homonymous district), five minutes away from Alexanderplatz.

The Ephraim Palace (German: Ephraim-Palais) is a Rococo-style building in Berlin, Germany, originally constructed in 1766. Despite the destruction of the palace in 1936 by Nazi Germany, the beginning of a reconstruction was possible in 1985, as many elements of the facade had been stored in East Germany. Today, the Ephraim Palace is a cultural-heritage property and houses a museum, mostly dealing with cultural topics. The Ephraim Palace is named after Veitel Heine Ephraim, who hired the experienced architect Friedrich Wilhelm Dieterichs to design a palace on the property of the oldest pharmacy of Berlin.

The Jüdenstraße (German: Street of the Jews), is a street in central Berlin, the capital of Germany. It is in the borough of Mitte and runs between Rathausstraße and Stralauer Straße, next to the Rotes Rathaus, Berlin's town hall. It is one of the oldest streets in Berlin, dating from the late 13th century. Its name preserves the old East Central German expression for Jews, which was Jüden, instead of New High German Juden. The Yiddish term for Jews «יידן» (transliterated: Yidn) is based on the same German dialect form, with the German umlaut ü being represented by a «י» (here pronounced [ɪ]). As the name of the street suggests, it once ran through the Jewish district of medieval Berlin, which was no ghetto-like obligatory residential area for Jews. An alley of Jüdenstraße named Großer Jüdenhof was the site of the synagogue, school and miqveh. They were founded on an estate of the Margrave of Brandenburg within his immunity district (landesherrliche Freiheit) not under Berlin's city council jurisdiction. Many Jews preferred to live close to these congregational institutions, until Elector Joachim I Nestor expelled the Jews from Brandenburg in 1510.