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Downtown Santa Ana (DTSA), also called Downtown Orange County, is the historic city center of Santa Ana, the county seat of Orange County, California. It is the institutional center for the city of Santa Ana as well as Orange County, a retail and business hub, and has in recent years developed rapidly as a regional cultural, entertainment and culinary center for Orange County. The Downtown Santa Ana Historic Districts are listed with the National Trust for Historic Preservation and consist of numerous historic buildings across the area.

The New Walker Theatre is a historic former movie theater on Main Street in Santa Ana, California. Opened in 1924, it came under new management as the Fox Walker Theatre in 1925 and later operated as the West Coast Theatre. Theater specialist firm Boller Brothers designed the building in the Mission Revival and Moderne styles; it was the group's 100th project. The New Walker Theatre was added to the National Register of Historic Places on February 19, 1982. Following its closure as a movie theater in the 1980s, the auditorium was later purchased and renovated by a church in 1991.

The Santora is a historic commercial building located in Downtown Historic District of Santa Ana, California. It now houses art galleries, retail stores, and restaurants.

The Odd Fellows Hall in Santa Ana, California, United States, also known as Odd Fellows Building, was built in 1906. It has served both as a clubhouse and as a commercial building. It was built by the Santa Ana Lodge No. 236, Independent Order of Odd Fellows. The Santa Ana Register, which became the Orange County Register, was the first tenant, on in its ground floor, and stayed until moving to larger quarters in 1913.In 1982, before a planned rehabilitation of the building, all of the "elaborate classical woodwork" in the Odd Fellows' lodge room on the second floor had survived and the building was one of the last remaining Late Victorian commercial buildings in the city.It was listed on the National Register of Historic Places in 1983.Its NRHP nomination states: "The Odd Fellows' building is a fine building with much character and fine architectural design, unique in Santa Ana's large commercial district.": 6 

The Old Orange County Courthouse, at one point also known as the Santa Ana County Courthouse, is a Romanesque Revival building that was opened in September 1901 and is located in Santa Ana's Historic Downtown District on Civic Center and Broadway streets. The Old Orange County Courthouse is officially recognized as California Historical Landmark No. 837 and is also on the National Register of Historic Places.

The Builders Exchange Building, at 202-208 N. Main St. in Santa Ana, California, was built in 1929. It was listed on the National Register of Historic Places in 1982.It was designed by architect William Rohrbacher in simplified Beaux Arts style. The building is currently owned by California-based General Contractor Swinerton Builders, CSLB 0092.

The West End Theater is a historic former movie theater on 4th Street in Santa Ana, California. Developer L. A. Schlesinger commissioned the theater in 1915 and architect James Flood Walker designed the building. It was later operated by Santa Ana theater proprietor C. E. Walker and named the State Theater. It showed arthouse and foreign film in the 1960s as the Guild Theater and was operated as an adult movie theater called the State Arts Theater in the 1970s. After the venue closed in 1978, the building survived a series of demolitions downtown. It has since been repurposed as a cafe.

The First Baptist Church of Santa Ana (1871–2019) was one of Orange County's pioneer Christian churches, believed to be the fifth Baptist church established in California.

The Yost Theater is a concert and events venue in Santa Ana, California. It is a National Register of Historic Places-listed building located in Santa Ana's Downtown Historic District. Under the ownership of the Olivos Family it became a movie house for the Golden Age of Mexican Cinema. In recent years it housed various church organizations and underwent renovation in 2007. It is currently an event venue that hosts such functions as concerts, Ted Talks, school dances, and weddings.

The Frida Cinema is a non-profit arthouse movie theater in Santa Ana, California. The theater, named after Mexican painter Frida Kahlo, is located in the 4th Street Market shopping district of the East End neighborhood in Downtown Santa Ana. The Frida has two screens and is the only non-profit theater in Orange County, California. The theater screens vintage blockbusters, cult classics, and independent films.

The Ronald Reagan Federal Building and Courthouse at 411 West Fourth Street in Santa Ana, California, is a ten-story United States federal building and courthouse on 3.94 acres (15,900 m2) that includes courtrooms, judges chambers, offices and courtroom galleries of the United States District Court for the Central District of California. Named for former President and California Governor Ronald Reagan in 1998, the building is owned by the General Services Administration and is 176 ft (54 m) tall.

Howe-Waffle House and Medical Museum is an 1889 Queen Anne style home in Santa Ana, California. It was the home of Dr. Willella Howe-Waffle, one of the first female physicians in Orange County, California, until her death in 1924.