San Jacinto Street Bridge over Buffalo Bayou

The Palace Hotel, located at 216 La Branch in Houston, Texas, was listed on the National Register of Historic Places on September 13, 2006.

White Oak Bayou is a slow-moving river in Houston, Texas. A major tributary of the city's principal waterway, Buffalo Bayou, White Oak originates near the intersection of Texas State Highway 6 and U.S. Highway 290 (the Northwest Freeway) and meanders southeast for 25 miles (40 km) until it joins Buffalo Bayou in Downtown. The river serves as a greenway which connects Downtown to the Houston Heights, Oak Forest, Garden Oaks, and Inwood Forest. A large majority of White Oak Bayou's route travels through highly developed areas. The river's 111-square-mile (290 km2) watershed contains a population of over 430,000.

Allen's Landing is the officially recognized birthplace of the city of Houston, Texas, United States, the largest city in Texas and the fourth largest in the United States. Located in Downtown Houston between the Main Street and Fannin Street viaducts, the landing encompasses the southern bank of Buffalo Bayou, the city's principal river, at its confluence with White Oak Bayou, a major tributary. Allen's Landing is located south of the University of Houston–Downtown Commerce Street Building. In August 1836, just months after the Republic of Texas won its independence from Mexico, two New York real estate developers, John Kirby Allen and Augustus Chapman Allen, purchased 6,642 acres (26.88 km2) of coastal prairie and settled the town of Houston on the banks of Buffalo Bayou. The present-day landing area was advertised as the head of navigation of the bayou and served as the city's first wharf.

Franklin Lofts, originally known as the Lomas & Nettleton Building, is an 8-story, 32 m (105 ft) building in downtown Houston, Texas. The building is generally regarded as the first skyscraper in the city. The Lomas & Nettleton Building was completed in 1904, and rises 8 floors in height. A new addition was completed in 1925. It was also the tallest steel-framed building west of the Mississippi River at the time of its completion.The Lomas & Nettleton Company was originally housed in the building, but it was converted to residential lofts and renamed in 1999.

The South Texas National Bank, located at 215 Main Street in Houston, Texas, was listed on the National Register of Historic Places on December 8, 1978. It was demolished for parking in 1983.

UH–Downtown is a station on the METRORail Red Line in Houston, Texas (USA) and it is the former northern terminus of the Red Line, since the line was extended in late 2013. The station is located on top of the Main Street viaduct at the campus of the University of Houston–Downtown (UHD). This station is located on top of the Main Street viaduct. Due to space limitations, it has an extremely narrow platform. As a result, the ticket vending machines are located on the property of the University of Houston–Downtown.

The One Main Building, formerly the Merchants and Manufacturers Building (commonly referred to as the M&M Building), is a building on the campus of the University of Houston–Downtown. The building is recognized as part of the National Register of Historic Places, is a Recorded Texas Historic Landmark, and considered a Contributing Building in Downtown Houston's Main Street/Market Square Historic District. The building was built above Allen's Landing—an area where Houston's founders John Kirby Allen and Augustus Chapman Allen originally settled. The Merchants and Manufacturers Building was built in 1930 and was the largest building in the city at the time. Although the commerce-focused building featured 14 miles of floor space and could accommodate one-third of the city's population, the Great Depression in the United States stifled initial participation. The building was purchased by South Texas Junior College in the 1960s, which became the University of Houston–Downtown College in 1974. The building remains as the largest facility of the University of Houston–Downtown and was given an official designation as "One Main Building," or simply the "Main Building," by the university.

Joe Kegans Intermediate Sanctions Facility is an Intermediate Sanctions facility of the Texas Department of Criminal Justice located along the northeast edge of Downtown Houston, Texas. The approximately 1 acre (0.40 ha) facility for men is located .5 miles (0.80 km) south of Interstate 10.The detention facility building that Kegans uses first opened in February 1995 as a place to house nonviolent offenders in order to relieve prison overcrowding. The unit closed after four months of use because not enough inmates had been put there to justify the additional expenses. The building had been unoccupied for two years before it re-opened in 1997. The building was formally dedicated at 10 A.M. on Wednesday October 15, 1997. As of 1997 all prisoners at the unit are convicted of parole violations such as non-violent property crimes. The unit was named after Joe Kegans, a state district judge who died in 1997 at 69 years of age.The Kegans Jail, along with the Pam Lychner State Jail, serves state jail offenders from Harris County. As of 2001 Kegans serves lower risk offenders.

The University of Houston–Downtown: College of Sciences and Technology (CST) is a University of Houston-Downtown program that prepares students for careers or post-graduate study and research in the sciences, technology, mathematics and computer science. The UHD Scholars Academy (SA) is an academically competitive program within CST for undergraduate students majoring in Science, Technology, Engineering and Mathematics (STEM).

The Harris County Courthouse of 1910 is one of the courthouse buildings operated by the Harris County, Texas government, in Downtown Houston. It is in the Classical Revival architectural style and has six stories. Two courtrooms inside are two stories each. It was listed on the National Register of Historic Places on May 13, 1981.It houses the Texas Court of Appeals districts 1 and 14.

The Pillot Building, located at 1006 Congress Avenue in Downtown Houston, Texas, was listed on the National Register of Historic Places on June 13, 1974. However, the structure suffered severe damage in the 1980s and collapsed during reconstruction in 1988. A replica of the original building, incorporating some of the original cast iron columns, sills, and lintels, was completed in 1990. The replica was removed from the National Register of Historic Places in 1994.The building was constructed between 1857 and 1869 by Eugene Pillot (1820-1896), and served a variety of tenants including a dry good merchant and professional offices. It was notable for cast iron front structure.

The Sam Houston Hotel is a historic hotel in Downtown Houston, Texas, United States that is listed in the National Register of Historic Places. The hotel received its listing on April 17, 2002.The Sam Houston Hotel Company built the hotel in 1924 to cater to the budget minded business traveler. It was designed by the firm Sanguinet, Staats, Hedrick & Gottlieb. The hotel operated until the 1970s by owners William and Vonnie Brooks. In 2002, it was bought by Randall D. Smith, his wife Barbara Stovall Smith (a Houston native), and his brother Jeffrey Smith, who extensively remodelled it and rebranded it in 2005 as the Alden Hotel, as the owners hoped to expand the Alden brand to other cities. The hotel offers 100 rooms and suites.In 2010, the ownership of the Alden Houston formally transferred to Northwood Investors. In 2012, Northwood sold the hotel to American Liberty Hospitality and Gentry Mills Capital and returned to its original name as The Sam Houston Hotel. It underwent a renovation in 2013.