Methodist Deaconess Institute—Esther Hall

First United Methodist Church is located in downtown Des Moines, Iowa, United States. It has been listed on the National Register of Historic Places since 1984 as First Methodist Episcopal Church, which is its original name.

St. Paul's Episcopal Cathedral, is located in downtown Des Moines, Iowa, United States. It is the cathedral church of the Episcopal Diocese of Iowa. The building was listed on the National Register of Historic Places as St. Paul's Episcopal Church.

The Des Moines Public Library (DMPL) is the public library system for the city of Des Moines, Iowa. It is the largest public library system in the state of Iowa, with a collection of 552,576 items housed at six locations.

The Marsh Engineering Company was a company that designed many significant bridges in the United States, including a number that survive and are listed on the National Register of Historic Places. It was located at 206 Masonic Temple in Des Moines, Iowa. The firm's principal engineer was James Barney Marsh (1856–1936), an engineer and bridge designer born in North Lake, Wisconsin. Works include: Dunkerton Bridge (1909), Town street over Crane Creek, Dunkerton, Iowa (NRHP-listed) Marsh Concrete Rainbow Arch Bridge (1911), Courtland, Minnesota, is a reinforced concrete through arch bridge, built in 1911 the same year that Marsh obtained a patent for his design. (NRHP-listed) Rainbow Arch Bridge at Valley City, North Dakota, (was NRHP-listed but was later removed) Squaw Creek Bridge (1917), 120th St. and V Ave. over Squaw Creek, Ridgeport, Iowa (NRHP-listed) Mederville Bridge (1918), County road over Volga River, Mederville, Iowa (NRHP-listed) First Avenue Bridge (1920), US 151 over Cedar River, Cedar Rapids, Iowa (NRHP-listed) Rainbow Arch Bridge (1922), CO 52, Fort Morgan, Colorado (NRHP-listed) River Street Bridge (1922-24), Iowa Falls, Iowa (NRHP-listed) Cotter Bridge, constructed in 1930, is the only bridge built by Marsh Engineering Company of Des Moines, Iowa in the state of Arkansas. It brings U.S. Route 62, over the White River, and opened up a large area of the Ozarks for recreation. (NRHP-listed) Henley Street Bridge, in Knoxville, Tennessee, designed in 1930The Wilson River Bridge (1931), near Tillamook, Washington, and others like it in Washington were designed by notable architect Conde McCullough, who had been employed at Marsh Engineering Company during the 1910s.

The Masonic Temple of Des Moines is a historic Beaux Arts style building located in Des Moines, Iowa. Constructed in 1913, it was listed on the National Register of Historic Places (NRHP) in 1997 (under the name "Masonic Temple of Des Moines").It was designed by the Des Moines-based architectural firm Proudfoot, Bird & Rawson. The building was listed on the NRHP for its architecture, as part of a 1988 multiple property submission. It was then one of 25 known surviving Proudfoot, Bird & Rawson buildings in Des Moines and is one of two known lodge buildings designed by the firm.: 10 As originally constructed, the building consisted of retail and office spaces on the first three floors, with Masonic meeting rooms on the fourth floor. In 2001 the Masons vacated their rooms on the fourth floor, which were converted into a venue for performing arts, culture entertainment and learning, billed as the Temple for Performing Arts.

Iowa Methodist Medical Center is a non-profit, 370-bed hospital in Des Moines, Iowa owned and operated by UnityPoint Health.

KUCB-FM was a radio station broadcasting on 89.3 FM in Des Moines, Iowa. The station aired programming aimed at the African American community in central Iowa. The station was on air from 1981 until 1998; its license renewal was successfully challenged in a seven-year legal battle that dragged on for most of the 1990s over an unauthorized two-year silence period and the illegal presence of a convicted felon as an officer of the station's licensee. A new minority station, KJMC, went on the air in 1999 as a result of a competing application to the license renewal.

The Hubbell Building is an historic building located in downtown Des Moines, Iowa, United States. It was listed on the National Register of Historic Places in 2004. It has been featured on the Discovery Channel show Dirty Jobs.

The Register and Tribune Building is a historic commercial building at 715 Locust Street in Des Moines, Iowa. Built in 1918, it served as home to The Des Moines Register, one of Iowa's leading newspapers, until about 2000, when the presses were moved to another building, and 2013, when the Register's owner, the Gannett Corporation, moved out in 2013. It was designed by one of Iowa's leading architectural firms, Proudfoot, Bird and Rawson, with later additions by equally prominent firms.The building was listed on the National Register of Historic Places in 2016.

The Des Moines Marriott Hotel is a high-rise hotel located in Downtown Des Moines, Iowa, United States. The building rises 33 floors and 365 feet (111 m) in height. It is currently the 3rd-tallest building in the city and the tallest hotel in Iowa. The structure was completed in 1981 and contains 417 guest rooms. The property had been previously occupied by the Royal Union Life Building.

John Stoddard Cancer Center is a cancer care center located in Central Iowa. It was the first cancer center in that location. The John Stoddard Cancer Center is a part of Iowa Health-Des Moines, where a number of important treatment options and services originated.

Burns United Methodist Church is located in Des Moines, Iowa, United States. Its previous building was listed on the National Register of Historic Places in 1977.