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The Centre at Salisbury is an 862,000-square-foot (80,082 m2) super regional mall in Salisbury, Maryland. The mall is the only regional shopping mall in a 60-mile (97 km) radius. The mall's anchor stores include Boscov's, Burlington, and Dick's Sporting Goods. It also features a 16 screen cinema stadium-style Regal Cinemas movie theater. The Centre at Salisbury is the largest shopping mall on the Eastern Shore of Maryland.

WTGM (960 AM) is a radio station broadcasting a sports format. Licensed to Salisbury, Maryland, United States, the station is currently owned by iHeartMedia. WTGM is located on the Delmarva Peninsula, and that is shown on the Fox Sports station logo.

The Poplar Hill Mansion is a historic U.S. mansion located at 117 Elizabeth Street, Salisbury, Maryland and is open to the public as a house museum.

Union Station is a historic railway station located at Salisbury, Wicomico County, Maryland, United States. It was constructed in 1913–14, near the junction where the New York, Philadelphia & Norfolk Railroad intersected with the Baltimore, Chesapeake and Atlantic Railroad (later, the Baltimore & Eastern Railroad) in the center of Salisbury. Both railroads became part of the Pennsylvania Railroad (PRR). It has a 1+1⁄2-story, Flemish bond brick main block covered by a medium-pitched hip roof sheathed in slate, with single-story wings. From the 1920s to the 1950s, the PRR ran several passenger trains a day, including the Del-Mar-Va Express, through the station, north–south from Philadelphia to Cape Charles, Virginia.The PRR terminated passenger service in 1958. It was converted from a passenger station into a freight facility, and since 1986 the station used for other commercial purposes. The building has characteristics of the Colonial Revival style and was the most elaborate passenger facility to survive on the Eastern Shore of Maryland.Union Station was listed on the National Register of Historic Places in 2007.

The Gillis-Grier House is a historic home located at Salisbury, Wicomico County, Maryland, United States. It is a 2+1⁄2-story Queen Anne style frame house built in 1887 by James Cannon. The house has gable-front elevations on three sides, a three-story octagonal tower, and a shorter 2+1⁄2-story service wing. Also on the property is a frame 1+1⁄2-story stable, now used as a garage. It is one of the dwellings that define Salisbury's Newtown neighborhood and named after the two inter-related families that held title to the property between 1896 and 1975.The Gillis-Grier House was listed on the National Register of Historic Places in 1972.

The Perry-Cooper House is a historic home located at Salisbury, Wicomico County, Maryland, United States. It is a three-story frame dwelling topped with a French mansard roof that was built about 1880. It features a central tower, with a bowed entrance on the first floor and a nine-foot-high Palladian window on the second. It was the residence of one of Salisbury's well-known civic leaders, Thomas Perry, whose family occupied the house from 1897 until 1950.The Perry-Cooper House was listed on the National Register of Historic Places in 1977.

Salisbury ( SAWLZ-bear-ee) is a city in and the county seat of Wicomico County, Maryland, United States. Salisbury is the largest city in the state's Eastern Shore region, with a population of 33,050 at the 2020 census. Salisbury is the principal city of the Salisbury, Maryland-Delaware Metropolitan Statistical Area. The city is the commercial hub of the Delmarva Peninsula, which was long devoted to agriculture and had a southern culture. It calls itself "The Comfortable Side of Coastal".

F. Leonard Wailes Law Office is a historic building located at Salisbury, Wicomico County, Maryland. It was constructed in 1927 in the Colonial Revival style. It is a two-story brick building opposite the Wicomico County Courthouse in a line of early- to mid-20th century commercial buildings.It was listed on the National Register of Historic Places in 1997.

The Maude R. Toulson Federal Building is a historic federal government building in Salisbury, Maryland. It is a large two-story brick building with Classical Revival styling. It has a nine-bay front facade, the center three projecting slightly, and is topped by a low balustrade punctuated by brick piers. The center bays have recessed arches, with windows in the outer of those bays flanking a center entrance. It was built in 1924–25 as a five bay building, with an enlargement in 1934–35; the original design was by the Office of the Supervising Architect under James A. Wetmore. The building initially housed the United States Post Office, and now houses other federal facilities, including the United States District Court for the District of Maryland.The building was listed on the National Register of Historic Places in 2016.

TidalHealth Peninsula Regional is a non-profit hospital located in Salisbury, Maryland. Established in 1897 by Dr. George W. Todd with six beds in an old home, the institution once known as Peninsula General Hospital has grown to contain approximately 300 beds. It serves nearly 500,000 patients every year in a multitude of specialties. Close to 2,000 babies are born at TidalHealth Peninsula Regional every year. There are approximately 3,300 employees, placing it among Salisbury's largest employers.Outside of its main hospital location, it includes a network of specialty and family physicians, a network of labs and pharmacies, plus two health complexes in Millsboro, Delaware and Ocean Pines, Maryland.Steven Leonard has been President/CEO since January 2018.In January 2020, Peninsula Health System, parent of the then named Peninsula Regional Medical Center, merged with Nanticoke Health Services of Seaford, Delaware. On September 1, 2020, the health system was officially renamed TidalHealth Services. The renaming coincided with a rebranding of all affiliated institutions with the TidalHealth branding.

Wicomico High School (commonly abbreviated "Wi Hi") is a high school located in Salisbury, Wicomico County, Maryland, United States. It is one of four public high schools in Wicomico County along with James M. Bennett High School, Mardela Middle and High School and Parkside High School. Wicomico High School currently enrolls grades 9 through 12. Its mascot is the Indian and its colors are blue and gold.

Sen. William P. Jackson House was a historic home located at Salisbury, Wicomico County, Maryland. It was a 3+1⁄2-story Queen Anne frame house completed in 1893. It was torn down in November 1976, after a ten-year battle to save it. It was built by United States Senator William P. Jackson.It was listed on the National Register of Historic Places in 1976.