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Sanford station is a railroad terminal in Sanford, Florida. It is the southern terminus for Amtrak's Auto Train, which runs between this station and Lorton, Virginia. As of 2022, the Auto Train loads its passengers on two tracks in Sanford, as no single track is long enough for all of the passenger railcars. A railroad crossing runs through the middle of Sanford's rail yard, an unusual situation for a modern station and yard.

Goldsboro is a community and former town in Seminole County, Florida. It was founded by the Freedmen's Bureau and later incorporated in 1891. One of the oldest African-American founded communities in the United States, it was established only a few years after nearby Eatonville. Angola, Florida, a settlement of escaped slaves, was established during Spanish rule in Florida. In 1911, the community was annexed into Sanford, Florida.

Sanford station is a SunRail commuter rail station in Sanford, Florida. It is the penultimate station in SunRail's phase one. It opened May 1, 2014, and marks the nine-year return of regular passenger rail service to Sanford following the closure of the Amtrak station in 2005. Sanford station is the northernmost SunRail station within Seminole County. Sanford is typical of most SunRail stations featuring canopies consisting of white aluminum poles supporting sloped green roofs and includes ticket vending machines, ticket validators, emergency call boxes, drinking fountains, and separate platforms designed for passengers in wheelchairs. The station is located along the north side of S.R. 46, diagonally across the road from the Sanford Amtrak Auto Train station. Other Amtrak trains that share the right-of-way with SunRail are the Silver Meteor and Silver Star trains, neither of which stop at either Sanford station. The station is also located just south of Rand Yard, a small rail yard used by CSX for freight car storage as well as SunRail for equipment maintenance and storage.

Sanford is a city in the U.S. state of Florida and the county seat of Seminole County. It is located in Central Florida and its population was 61,051 as of the 2020 census. Known as the "Historic Waterfront Gateway City", Sanford sits on the southern shore of Lake Monroe at the head of navigation on the St. Johns River. Native Americans first settled the area thousands of years before the city was formed. The Seminoles arrived in the area in the 18th century. During the Second Seminole War in 1836, the United States Army established Camp Monroe and built a road now known as Mellonville Avenue. Sanford is about 20 miles (32 km) northeast of Orlando. Sanford is home to Seminole State College of Florida and the Central Florida Zoo and Botanical Gardens. Its downtown attracts tourists with shops, restaurants, a marina, and a lakefront walking trail. The Orlando Sanford International Airport, in the heart of the town, functions as the secondary commercial airport for international and domestic carriers in the Orlando metropolitan area.

The Sanford Grammar School, also known as the Sanford High School and as the Margaret K. Reynolds Building, is a historic school building located at 301 West 7th Street in Sanford, Florida, United States. Built in 1902, it was designed by Wilbur B. Talley in the Romanesque Revival style of architecture. Sanford architect Elton James Moughton designed the wings which were added in 1916. On November 23, 1984, it was added to the U.S. National Register of Historic Places. In 1989, it was listed in A Guide to Florida's Historic Architecture prepared by the Florida Association of the American Institute of Architects and published by the University of Florida Press.

The Sanford Residential Historic District is a U.S. Historic District (designated as such on December 15, 1989) located in Sanford, Florida. The district is bounded by Sanford Avenue, 14th Street, Elm Avenue, and 3rd Street. It contains 432 historic buildings, including the Old Fernald-Laughton Memorial Hospital and Sanford Grammar School.

The Old Fernald-Laughton Memorial Hospital (also known as the Florida Hotel or George Fernald House) is a historic site in Sanford, Florida, United States. It is located at 500 South Oak Avenue. On May 21, 1987, it was added to the U.S. National Register of Historic Places.

Seminole High School, originally established as Sanford High School, is a public high school located in Sanford, Florida, operated by Seminole County Public Schools. From 2006 to 2011, Seminole High School was one of the schools in Seminole County on Newsweek's list of the top 1,200 schools in the United States. The school offers the International Baccalaureate Diploma Programme. The Academy for Health Careers provides a curriculum based on a future career in health care. Students take a health class and health material is integrated into the curriculum of all other subjects. Seminole High also offers Advanced Placement courses in a range of subjects.

The Sanford Commercial District is a U.S. Historic District (designated as such on June 15, 1976) located in Sanford, Florida. The district includes parts of 1st, 2nd, and Commercial Streets, between Palmetto and Oak Streets. It contains 29 historic buildings, including the PICO Building at 209 North Oak.

The PICO Building, also known as the PICO Hotel, is an historic 2-story redbrick building located at 209 North Oak Avenue, corner of West Commercial Street, in Sanford, Florida. Built during 1886-1887 for Henry B. Plant of Plant Investment Co. (PICO) to serve travelers arriving in Sanford on his railroad and steamship lines, it was designed by local architect William T. Cotter in the Romanesque Revival and Moorish Revival styles of architecture and built by the H. M. Papworth Construction Company. In 1906 the building was remodeled and sold to the Takach family, which had operated the restaurant for Plant by Mrs. Bertha E. Takach and family, Hungarian immigrants. According to the Orlando Sentinel on April 22,1973, "Mrs. Takch, the owner (of an adjacent restaurant), had such good food... she got all the customers. So, in 1889, Mr. Plant, whose dining room was losing out, made a deal with Mr. and Mrs. G. L. Takach to take over their Pico Hotel." In fact, "they DID, in 1891...from that time, many called the Pico Hotel the Takach Hotel. It had gas lights, white table cloths, and the people who ate there were well dressed, as train travelers always were in that era." "Their restaurant continued in the building for about 50 years. The building's original onion dome was destroyed in a 1950s storm. The building then went on to become an office building used primarily for law offices. In 1989, it was listed in A Guide to Florida's Historic Architecture prepared by the Florida Association of the American Institute of Architects and published by the University of Florida Press.The building is a contributing property in the Sanford Commercial District, which was added to the National Register of Historic Places on June 15, 1976.

The Ritz Theater (also known as the Milane Theatre or the Helen Stairs Theatre) is a historic theatre in Sanford, Florida, United States. It is located at 201 South Magnolia Avenue. On January 29, 2001, it was added to the U.S. National Register of Historic Places. After getting donations from Wayne Densch it has now been named the Wayne Densch Performing Arts Center.

St. James A. M. E. Church is a congregation of the African Methodist Episcopal Church in Sanford, Florida, United States. The oldest church in Sanford founded by African Americans, it was established in 1867, when the church purchased land on the corner of East Ninth Street and South Cypress Avenue. The original church building was replaced in 1913 with a red brick Gothic Revival building designed by local architect Prince W. Spears. In 1989, it was listed in A Guide to Florida's Historic Architecture prepared by the Florida Association of the American Institute of Architects and published by the University of Florida Press. On April 24, 1992, it was added to the U.S. National Register of Historic Places.