Edward L. Westbrooke Building

On December 26, 1920, an African-American man named Wade Thomas was lynched in Jonesboro, Arkansas, by a white mob. The mob seized Thomas from the Jonesboro jail after he allegedly shot local Patrolman Elmer Ragland, and murdered him.

The Craighead County Courthouse is located at 511 Main Street, in the center of Jonesboro, Arkansas, the county seat of Craighead County. It is a two-story brick structure with limestone trim, built in 1934, and is the city's only significant example of Art Deco architecture. The building has a stepped appearance, with a large central block that has an oversized second story, and is flanked by smaller two-story wings, from which single-story sections project to the front and back. Vertical panels of fluted limestone accentuate corner projections from the main block, a motif repeated near the roof line of that block. The main entrance is recessed in an opening flanked by similarly fluted panels. The courthouse is the fifth of the county to stand on the site. Near the entrance to the courthouse stands a copy of John Paulding's World War I memorial, Over the Top, placed in 1920, and often confused with E. M. Viquesney's "Spirit of the American Doughboy".The courthouse was listed on the National Register of Historic Places in 1998.

The Jonesboro U.S. Post Office and Courthouse is a former federal building located at 524 South Church Street, in downtown Jonesboro, Arkansas. It is a three-story masonry structure, built out of brick and limestone. The ground floor is visually presented as a basement level clad in red brick, while the upper levels are finished in stucco with brick trim. Although the building lacks rounded-arch openings normally found in the Renaissance Revival, it is laid out along lines typical of that style, with the courtrooms on the second floor in the piano nobile style. The building was built as a courthouse and post office in 1911–13 to a design by James Knox Taylor, the Supervising Architect of the United States Treasury. It was used as a federal courthouse until 1977, and has seen a variety of commercial uses since then.The courthouse was listed on the National Register of Historic Places for its architecture in 2019.

The Mercantile Bank Building is a historic bank building at 249 South Main Street in Jonesboro, Arkansas. The brick building was built in 1890 for Craighead County Bank. The bank used the building until 1894. It was then used as a clothing store and for offices afterwards until 1901 when it was occupied by Jonesboro Savings & Trust, (later known as the Jonesboro Trust Company). The architectural firm of Hoggson Brothers conducted a 1919 update and remodel of the building. Jonesboro bank closed in 1931 and, after fundraising efforts to open a new bank in the town, Mercantile Bank opened in the building in 1932. Mercantile moved its bank in 1969 and Crowley's Ridge Development Council used the building until 2004.The building was listed on the National Register of Historic Places in 2005.

Craighead County is a county located in the U.S. state of Arkansas. As of the 2020 census, the population was 111,231. The county has two county seats — Jonesboro and Lake City. Craighead County is Arkansas's 58th county, formed on February 19, 1859, and named for state Senator Thomas Craighead. It is one of several dry counties within the state of Arkansas, in which the sale of alcoholic beverages is largely prohibited. Craighead County is included in Jonesboro–Paragould Combined Statistical Area.

The Nash-Reid-Hill House is a historic house at 418 West Matthews Avenue in Jonesboro, Arkansas. It is a 2+1⁄2-story wood-frame house, faced in brick veneer, with a hipped roof that has multiple cross gables and a three-story tower with a conical roof. The house was built between 1898 and 1902, using locally fired brick, and is a locally notable example of Queen Anne architecture, although its porch was modified in 1934 to give it a more French Eclectic appearance. It is also notable for its association with the locally prominent Nash family, who have long been prominent businessmen and landowners in the years since the American Civil War.The house was listed on the National Register of Historic Places in 1994.

St. Bernards Medical Center is a 440-bed acute-care hospital in Jonesboro, Arkansas. The hospital, established on July 5, 1900, is the flagship facility of its nonprofit parent, St. Bernards Healthcare, serving as a regional referral center for 23 counties in northeast Arkansas and southeast Missouri. St. Bernards Medical Center is the only Level III trauma center in the region and houses the only Neonatal Intensive Care Unit (NICU) in the eastern part of Arkansas.

The C.A. Stuck and Sons Lumber Mill is a historic industrial complex at 215 Union Street in Jonesboro, Arkansas. It consists of four buildings: an office building, a lumber mill, and two storage sheds. All four buildings are brick structures built c. 1890, although the office building was enlarged and given a new facade in 1905. The Stuck mill, which was established in 1889, is one of the oldest properties associated with the early efforts to deforest Craighead County. C.A. Stuck was an Illinois-based furniture builder who moved to Jonesboro to facilitate the production of lumber for his products.The complex was originally listed on the National Register of Historic Places in 2002. In 2018 it was simultaneously delisted and relisted. It was again delisted in 2019.

The Bell House is a historic house at 303 West Cherry Street in Jonesboro, Arkansas. It is a two-story wood-frame structure, built in 1895 by J. V. Bell, owner of one of Jonesboro's first bookstores. The house is an elaborately-decorated Queen Anne Victorian, with an asymmetrical arrangement of projecting bays, gables, and porches. The front porch has a delicate spindle-work frieze, and is supported by turned columns. Different types of cut shingles give variety to the wall surfaces.The house was listed on the National Register of Historic Places in 1976.

The Community Center No. 1 is a historic government building at 1212 South Church Street in Jonesboro, Arkansas, USA. It is a single-story building, faced in buff brick, with a stylish Art Deco entrance area consisting of towers and projections made of smooth white concrete. The entrance is flanked by large flat-roof sections which house recreational facilities, while the center section has a low-pitch gable roof. The community center was designed by Elmer A. Stuck, and built in 1936 with funding from the Public Works Administration. The center has undergone several name changes, and is now known as the Earl Bell Community Center, after the Olympic pole vaulter and Jonesboro native.The building was listed on the National Register of Historic Places in 2008.

The Frierson House is a historic house at 1112 South Main Street in Jonesboro, Arkansas. It is a two-story wood-frame structure, with a hip roof pierced by gabled dormers. The main facade is covered by a two-story porch with Ionic columns, with a single-story porch on the side with Doric columns. The main entrance is flanked by sidelight windows and topped by a multilight transom, and is set in a recessed paneled entry framed by pilasters. Its construction date is uncertain, but is placed between 1870 and 1910 based on architectural evidence. It is a well-preserved example of a post-Civil War "town house".The house was listed on the National Register of Historic Places in 1973.

The Berger House is a historic house at 1120 South Main Street in Jonesboro, Arkansas.