Enterprise Cotton Mills Building

Whitman Street Area Historic District is a national historic district located at Orangeburg, Orangeburg County, South Carolina. The district encompasses 12 contributing buildings in a residential section of Orangeburg. They include large, two-story frame houses constructed in the late-19th and early-20th century. The houses are in a variety of popular architectural styles including Victorian, Queen Anne, Classical Revival, and Colonial Revival.It was added to the National Register of Historic Places in 1985.

Williams Chapel A.M.E. Church is a historic African Methodist Episcopal church located at 1198 Glover Street in Orangeburg, Orangeburg County, South Carolina. It was built between 1915 and 1925, and is a one-story, brick Gothic Revival-style church building on a raised basement. It features two towers on the facade with pyramidal roofs and Gothic arched stained glass windows.It was added to the National Register of Historic Places in 1985.

The Church of the Redeemer is a parish of the Anglican Diocese of South Carolina, affiliated with the Anglican Church in North America, in the city of Orangeburg, South Carolina. The first Anglican church in Orangeburg Township was established in 1749 by the Rev. John Giessendanner, and a chapel at Orangeburg was later provided by the Act of 1768, which created St. Matthew's Parish in Ft. Motte, South Carolina. Following a long dormant period, the Church of the Redeemer was organized. The current building was erected between 1854 and 1855 on Boulevard Street, near the corner of Amelia, where the cemetery remains. The structure, which features Louis Comfort Tiffany stained glass windows, was moved to its present site, improved and renovated in 1895.In November 2012, the congregation, along with other churches in the Episcopal Diocese of South Carolina, left the national Episcopal Church of the United States, and in June 2017, formally joined the Anglican Church in North America.

East Russell Street Area Historic District is a national historic district located at Orangeburg, Orangeburg County, South Carolina. The district encompasses 55 contributing buildings in a residential section of Orangeburg. They include residences constructed between about 1850 and 1930, and includes large, one- and two-story, frame and brick houses and smaller one-story homes occupied by servants. The houses are in a variety of popular architectural styles including Victorian, Colonial Revival, and Bungalow.It was added to the National Register of Historic Places in 1985.

Orangeburg County Fair Main Exhibit Building is a historic county fair exhibition hall and grandstand located at Orangeburg, Orangeburg County, South Carolina. It was built in 1911, and is a one-story, rectangular, frame building. It sits on an open, brick pier foundation and has shiplap siding and a low-pitched gable roof.It was added to the National Register of Historic Places in 1985.

Hotel Eutaw, also known as the East Russell Street Inn, is a historic hotel located at Orangeburg, Orangeburg County, South Carolina. It was designed by architect G. Lloyd Preacher and built in 1926–1927. It is a seven-story, steel-frame with brick veneer, skyscraper with an L-shaped plan. The front façade features a projecting one-story, six-bay, cast stone entrance block.It was added to the National Register of Historic Places in 1985.

The (Old) Orangeburg County Jail, also known as The Pink Palace, is a historic jail located at Orangeburg, Orangeburg County, South Carolina. It was built between 1857 and 1860, and is a two-story, rectangular, cement-covered brick building in the Late Gothic Revival style. It features a crenellated main tower and corner turrets. General William Tecumseh Sherman’s troops burned the building in February 1865; it was subsequently restored.It was added to the National Register of Historic Places in 1973.Orangeburg County inmates are now kept in the Orangeburg-Calhoun Regional Detention Center.

All-Star Triangle Bowl (formerly All-Star Bowling Lane) is a former bowling alley located in Orangeburg, South Carolina, United States. The 16 lanes in total are a historic fixture of the community. The original owner was Harry K. Floyd, and originally housed both AMF's Magic Triangle systems and 82-30 pinsetters. All-Star Triangle Bowl is most known for its fundamental role in the Orangeburg Massacre, which was sparked as a result of Floyd refusing to allow people of color to bowl at the privately owned bowling alley (which was then called All Star Bowling Lane). He owned and operated the alley until his death on July 12, 2002, following which his son, Harry K. Floyd, Jr., took over. Due to financial difficulties, the Floyd family closed the bowling alley in August 2007. The All-Star Triangle Bowl remains on the National Register of Historic Places. In September 2020, an Orangeburg nonprofit purchased the property with the plan of turning it into a memorial for the Civil Rights Movement in the city, to be called the Orangeburg National Center for Justice.

The Orangeburg Massacre was a shooting of student protesters that took place on February 8, 1968, on the campus of South Carolina State College in Orangeburg, South Carolina, United States. Nine Highway Patrolmen and one city police officer opened fire on a crowd of African American students, killing three and injuring twenty-eight. The shootings were the culmination of a series of protests against racial segregation at a local bowling alley, marking the first instance of police killing student protestors at an American university. Two days before the shootings, student activists had been arrested for a sit-in at the segregated All-Star Bowling Lane. When a crowd of several hundred Claflin and South Carolina State College (State College) students gathered outside the bowling alley to protest the arrests, police dispersed the crowd with billy clubs. Students requested permission to hold a march downtown and submitted a list of demands to city officials. The request for a march was denied, but city officials agreed to review the demands. As tensions in Orangeburg mounted over the next few days, Governor Robert McNair ordered hundreds of National Guardsmen and Highway Patrol officers to the city to keep the peace. On the night of February 8, students from both colleges and Wilkinson High School started a bonfire at the front of State College's campus. When police moved to put out the fire, students threw debris at them, including a piece of a wooden banister that injured an officer. Several minutes later, at least nine patrolmen and one city police officer opened fire on the crowd of students. Dozens of fleeing students were wounded; Sam Hammond, Henry Smith, and Delano Middleton were later pronounced dead at the Orangeburg Regional Hospital. In the aftermath of the killings, the bowling alley and most remaining whites-only establishments in Orangeburg were desegregated. Federal prosecutors charged nine patrolmen with deprivation of rights under color of law by firing on the demonstrators, but they were acquitted in the subsequent trial. The state of South Carolina charged one of the protestors, Cleveland Sellers, with several riot charges. He was convicted on charges relating to events two days before the massacre. Sellers received a full pardon in 1993. In 2001, Jim Hodges became the first governor to make a formal apology for the massacre.

Lowman Hall is a historic academic building located on the campus of South Carolina State University at Orangeburg, Orangeburg County, South Carolina. It was built in 1917, and is a three-story, hip roofed, brick building, with projecting end pavilions. The front façade features a one-story, tetrastyle Ionic order portico. It was originally used as a men's dormitory.It was added to the National Register of Historic Places in 1985. It is part of the South Carolina State College Historic District.

Trinity Methodist Episcopal Church is a historic Methodist Episcopal church located at 185 Boulevard NE in Orangeburg, Orangeburg County, South Carolina. It was built between 1928 and 1944 and is a two-story, brick Late Gothic Revival-style church building on a raised basement. It features a large Tudor arched stained glass window with molded cast stone surround.It was added to the National Register of Historic Places in 1994.

South Carolina State College Historic District is a national historic district located on the campus of South Carolina State University at Orangeburg, Orangeburg County, South Carolina. The district encompasses 10 contributing buildings, 1 contributing site, and 1 contributing object at the core of the historically black university. They were constructed between 1917 and 1950, and include a variety of architectural styles including Classical Revival and International Style. Notable buildings include the separately listed Hodge Hall and Lowman Hall, along with Home Management House, Mechanical Industries Hall, and Wilkinson Hall. Also on the campus, but located outside the district, is Dukes Gymnasium. It was added to the National Register of Historic Places in 1997.